Hamdullah PEKKOLAY, Önder SAKİN, Zehra Meltem PİRİMOĞLU, Gülhan BAYRAKTAR

Menopoz sonrasına bırakılan uterin myomların gelişen endometrium kanseri üzerine olumsuz etkileri var mıdır?

Amaç: Endometrium kanseri ve myoma uteri, gelişmiş ülkelerde en sık görülen malign ve benign tümörlerdir. Endometrium kanseri nedeniyle opere olan kadınlarda myoma uterinin de yüksek oranlarda eşlik ettiği görülmektedir. Premenopozal dönemde konservatif bir yaklaşım ile, medikal tedavilerle menopoz sonrasına ertelenen premenopozal myomların olası endometrium kanseri üzerine herhangi bir olumsuz etkisinin bulunup bulunmadığı araştırıldı. Gereç ve Yöntem: Çalışmada Ocak 2005 - Şubat 2011 yılları arasında hastanemizde opere edilmiş ve araştırma kriterlerine uyan 127 hasta dosyası retrospektif olarak incelendi. Sosyodemografik özellikleri, obstetrik öyküleri, myom varlığı, endometrial tümör varlığı, tümör derecesi, myometriuma invazyon derecesi değerlendirildi ve anlamlılığı araştırıldı. Bulgular: Endometrial karsinom prognozuna etkili faktörlerden yaş, histolojik tip, histolojik derece ve myometrial invazyon durumlarının myoma uteri ile ilişkisi bulunmadığı belirlendi. Sonuç: Kadınlarda en sık görülen jinekolojik kanser olan endometrium kanseri ile en sık görülen benign tümörü olan myoma uterinin beraberlikleri araştırılmış ve endometrium kanserinin histopatolojik prognostik bulgularının myoma uteri varlığıyla değişmediği, dolayısıyla prognoza olumsuz etkisinin olmadığı sonucuna ulaşılmıştır.

Anahtar Kelimeler:

Endometrium kanseri, myoma uteri, risk faktörleri, postmenopoz

Do uterine fibroids which are left to postmenopausa have any negative effects on the developing endometrial cancer?

Objective: Endometrial cancer and uterine leiomyoma are the most common malignant and benign tumors in developed countries. In women operated for endometrial cancer, accompanying uterine myome is observed in high rates. The treatment of the premenopausal myomas is delayed after the menopause conservatively.Yet it is unclear whether this approach has any negative effect on possible endometrial cancer. The goal of this study is to investigate the relationship between premenopausal myomas and the prognostic factors of endometrial cancer.Material and Method: The files of 127 patients who were operated between January 2005 and February 2011 in our hospital fulfilling the criteria were investigated retrospectively. Sociodemographic characteristics, obstetric traits, myoma presence, endometrial tumor presence, tumor grade, myometrial invasion grade were evaluated and significance was investigated.Results: Factors affecting the prognosis of endometrial carcinoma; age, histological type, histological grade and myometrial invasion were found to be not significantly related to myoma uteri. Conclusion: Endometrial cancer, the most common gynecologic cancer in women, and uterine myoma, the most common benign tumor, were investigated together. The histopathological prognostic findings of endometrial cancer are unchanged by the presence uterine myoma. Therefore we reached the conclusion that there is no negative impact on prognosis.

Keywords:

Endometrial neoplasms, myoma uteri, risk factors, postmenopause,

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