Mediastinal Castleman Hastalığı: İki olgu sunumu ve literatürün gözden geçirilmesi

Castleman hastalığı, yaş ve cinsiyetten bağımsız olarak görülen lenf nodlarının aşırı büyümesidir. Kliniğimizde cerrahi olarak tedavi edilen ve histopatolojik inceleme sonunda Castleman hastalığı tanısı alan 37 yaşında kadın ve 38 yaşında erkek olgular tartışılmak-tadır. Her iki hastaya da tanısal torakotomi yapılarak kitleler rezeke edilmiş ve patoloji sonuçları hyaline-vasküler tipte Castleman hastalığı olarak bildirilmiştir. Olgular halen takip altında ve asemptomatiktirler

Mediastinal Castleman’s Disease: Report of two cases and review of the literature

Castleman’s disease is an enlargement of lymph nodes without differentiaton of age and sex. A 37-year-old woman and a 38-year-old man patients were treated surgically in our clinic who were diagnosed as Castleman’s disease with histopathological examination. For both of the patients diagnostic thoracotomy was performed and tumoral masses were resected. Postoperatively, hyaline-vascularized type Castleman’s disease was diagnosed and our patients were remained asymptomatic at follow-up. Our patients were remained asymptomatic for follow-up after operation.

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  • 1. Olak J. Benign lymph node disease involving the medias-tinum In: Thomas W Shields, General Thoracic Surgery, 6th Edition. Philadelphia, Lippincott Williams & Wilkins; 2005;2676-2681.
  • 2. Gaba AR, Stein RS, Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol 1978; 1: 86-90.
  • 3. Burger R, Neipel F, Fleckenstein B, et al. Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 1998; 6: 1858-1863.
  • 4. Cazorla Jimenez A, Gorgolas Hernandez - Mora M, Fernandez Guerrero M, Renedo Pascual G, Rivas Manga C. Multicenter Castleman disease in AIDS. Its relationship with HHV–8 or herpes virus associated to Kaposi's sarcoma. Study of two cases. Rev Clin Esp 2005; 12: 607-609.
  • 5. Hung IJ, Lin JJ, Yang CP, Hsueh C. Paraneoplastic syndrome and intrathoracic Castleman disease. Pediatr Blood Cancer 2006; 5: 616-620.
  • 6. Parez N, Bader-Meunier B, Roy CC, Dommerques JP. Paediatric Castleman disease: report of seven cases and review of the literature. Eur J Pediatr 1999; 8: 631-637.
  • 7. Mimouni D, Anhalt GJ, Lazarova Z, et al. Paraneoplastic pemphigus in children and adolescents. Br J Dermatol 2002; 4: 725-732.
  • 8. Herrada J, Cabanillas F, Rice L, Manning J, Pugh W. The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med 1998; 8: 657-662.
  • 9. Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome. Blood 2003; 7: 2496-2506.
  • 10. Delmer A, Karmochkine M, Le Tourneau A, et al. Castleman's disease (giant lymph node hyperplasia): clinical, biological and developing polymorphism. Apro-pos of 4 cases. Ann Med Interne 1990; 2: 123-128.
  • 11. Ozkan H, Tolunay S, Gozu O, Ozer ZG. Giant lymphoid hamartoma of mediastinum (Castleman’s Disease). Tho-rac Cardiovasc Surg 1990; 38: 321-323.