Fatoş ÖNEN, Dilek TUNCER, Servet AKAR, Merih BİRLİK, Nurullah AKKOÇ

Behçet hastalıklı olgularda Borrelia burgdorferi seroprevalansı

Amaç: Behçet hastalıklı olgularda B. burgdorferi antijenlerine karsı seroreaktivitenin araştırılması. Gereç ve Yöntem: Araştırma, yurdumuzun batısında yer alan izmir'de yapılmıştır. Behçet hastalıklı (n=30), romatoid artrit (RA)'İ olan hasta kontrol (ıı=31) ve sağlıklı kontrol (n=31) gruplarının serumlarında B. burgdorferi IgM ve IgG antikorları, enzim immünoassay yöntemiyle ölçülmüştür. Pozitif sonuçlar Western blot ile doğrulanmıştır. Bulgular: B. burgdorferi seropozitifliği yönünden, gruplar arasında, her 2 yöntemle de anlamlı fark bulunmamıştır. B. burgdorferi antijenlerine karsı seroreaktivite enzim immünoassay yöntemiyle, Behçet hastalıklı olguların %26,7'sinde, RA'lilerin %35,5'inde ve sağlıklı kontrollerin %19,4'ünde saptanmıştır. İmmunoblot sonuçlarının ise Behçet hastalıklıların %13,3'ünde, RA'lilerin %22,6'smda ve sağlıklı kontrollerin %13,3'ünde pozitif olduğu görülmüştür. Sonuç: Bu sonuçlar, B. burgdorferi ile Behçet hastalığı arasında bir ilişki olmadığını düşündürmektedir. Ancak hem hasta, hem de kontrol gruplarındaki yüksek B. burgdorferi antikor sıklığı, Türkiye'nin bu bölgesinde, hastalık ile uyumlu klinik bulgulaıı olan hastalarda, Lyme hastalığının akla getirilmesi gerektiğini göstermektedir.

Anahtar Kelimeler:

Behçet sendromu, Borrelia burgdorferi, Araştırma teknikleri, Seroepidemiyolojik çalışmalar

Seroprevalence of Borrelia burgdorferi in patients with Behçet disease

Objective: To investigate the seroreactivity to B. burgdorferi antigens in patients, with Behçet's disease. Materials and method: The study was conducted in Izmir located in the western part of Turkey. B. burgdorferi IgM and IgG antibodies were tested by enzym immünoassay in the sera of patients with Behçet's disease (n=30), rheumatoid arthritis (RA) patients as disease controls (n=31) and healthy controls (n=31). Positive results were confirmed by Western blotting. Results: The difference in B. burgdorferi seropositivity between the groups was not significant by any method. Seroreactivity to burgdorferi antigens by the microELISA system was detected in 26.7 % of patients widi Behçet's disease, 35.5 % of patients with RA and 19.4 % of healthy controls. Immunoblots were positive in 13.3 % of Behçet's disease patients, 22.6 % of RA patients, and 13.3 % of healthy controls. Conclusion: These results suggest no association between Behçet's disease and B. bitrgdorferi seropositivity. However high prevalence of B. burgdorferi antibodies in both patient and control groups suggests that Lyme disease should be considered in patients with appropriate clinical findings in this area of Turkey.

Keywords:

Behcet Syndrome, Borrelia burgdorferi, Investigative Techniques, Seroepidemiologic Studies,

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