Organ Nakli Sonrası Doğum Kontrol Yöntemleri, Gebelik ve Emzirme

Amaç: Bu literatür incelemesinin amacı, organ nakli sonrası doğum kontrol yöntemi kullanımı, gebelik ve emzirme ile ilgili var olan literatür bilgisini incelemektir. Sonuçlar: Organ nakli sonrası güvenli ve etkili doğum kontrol yöntemleri konusunda literatürde farklı bilgiler yer almaktadır. Organ nakli sonrası hastaların doğum kontrol yöntemleri konusunda bilgilendirilmeye gereksinimleri vardır. Karaciğer ve böbrek nakli hastalarında gebelik sırasında; en fazla hipertansiyon, gestasyonel diabet ve preeklemsi olmak üzere sağlıklı popülasyondan daha fazla sorun geliştiği görülmektedir. Bebeklerde, en fazla erken doğum ve düşük doğum ağırlığının görülmesine rağmen malformasyon görülme durumunun sağlıklı popülasyona yakın olduğu belirtilmiştir. Hastalarda daha az sorun görülmesi için multidisipliner bir yaklaşım içerisinde, hemşirenin hastanın bakım gereksinimini belirlemesine ve bu konuda uygun bakımı yürütmesine yönelik kanıtlar oluşturulmasına gereksinim vardır.

Anahtar Kelimeler:

Organ Nakli, Doğum Kontrol Yöntemi, Gebelik, Emzirme

Contraceptive Methods, Pregnancy And Breastfeeding After Organ Transplantation

The purpose is to review the literature on birth control methods, pregnancy and breastfeeding after organ transplantation. Information on safe and effective birth control methods after transplantation in the literature varies. Patients need to be informed about birth control methods after organ transplantation. It has been observed that liver and kidney transplant patients develop health problems including hypertension, gestational diabetes and preeclampsia during pregnancy more than do healthy people. Although the incidence of premature or low-birth weight infants is higher among them, the malformation incidence is stated to be close to that in normal population. In order to have fewer problems in transplant patients, a multidisciplinary approach should be displayed, and nurses should be able to determine the patient's nursing care needs and maintain the appropriate care

Keywords:

Organ transplantation, Contraceptive methods, Pregnancy, Breastfeeding,

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Bramhan, K., Nelson-Piercy, C., Gao, H., Pierce, M., Bush, N., Spark, B., Brocklehurst, P., Kurinczuk, J.J., Knight, M. (2013). Pregnanacy in renal transplant recipients: A UK National cohort study. Clin J Am Soc Nephrol. 8(2): 290-298.
Deshpande, N.A., James, N.T., Kucirka, L.M., Boyarsky, B.J., Garonzik-Wang, J.M., Montgomery, R.A.
Segev, D.L. (2011). Pregnancy outcomes in kidney transplant recipients: a systematic review and metaanalysis. Am J Transplant. 11: 2388-2404. Dünya Sağlık Örgütü-DSÖ (2009). World Health
Organization-A WHO Family planning Medical Eligibility Criteria for Contraceptiev Use. 4th Edition. Estes, C.M., Westhoff, C. (2007). Contraception for the transplant patient. Semin Perinatol. 31:372–7.
Fedorkow, D.M., Corenblum, B., Shaffer, E.A. (1989). Cholestasis induced by oestrogen after liver transplantation. BMJ, 299: 1080-1
French, A.E., Soldin, S.J., Soldin, O.P,, Karen, G. (2003). Milk transfer and neonatal safety of tacrolimus. Ann Pharmacother, 37: 815.
Gardiner, S.J., Begg, E.J. (2006). Breastfeeding during tacrolimus therapy. Obstet Gynecol, 107: 453.
Gouraud A, Bernard N, Millaret A, Bruel M, Paret N, Vial T. Serum level of tacrolimus in of breastfeed infant and long term follow-up. Fundamental and Clinical Pharmacology 2011; 25 Suppl: 103.
Guazzelli, C.A., Torloni, M.R., Sanches, T.F., Barbieri, M., Pestana, J.O. (2008). Contraceptive counseling and use among 197 female kidney transplant recipients. Transplantation, 86:669–72.
Hebert, M.F., Zheng, S., Hays, K., Shen, D.D., Davis, C.L, Umans, J.G., Miodovnik, M., Thummel, K.E., Easterling, T.R. (2013) Interpreting Tacrolimus Concentrations Du-ring Pregnancy and Postpartum, Transplantation, 95(7): 908-915
Jabiry-Zieniewicz, Z., Bobrowska, K., Kaminski, P., Wielgos, M., Zeinewicz, K., Krawezyk, M. (2007). Low-dose hormonal contraception after liver transplantation. Transp-lant Proc, 39: 1530-2
Jain, A.B., Reyes, J., Marcos, A., Mazairegos, G., Eghtesad, B., Fontes, PA., Cacciarelli, T.V., Marsh, J.W., de Venca, ME., Starel, T.E., Ve Fung J.J. (2003). Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center’s experience update at 13 years. Transplantation, 76: 827-832.
Jones, A., Clary, M.J., McDermott, E., Coscia, C.A., Constantinescu, S., Moritz, M.J., Armenti, V.T. (2013). Outcomes of pregnancies fathered by solidorgan transplant recipients exposed to mycophenolic acid prodeuct, Progress in Transplantation, 23(2); 153-157
Kainz, A., Harabacz, I., Cowlrick, I.S., Godgil, S.D., Hagiusara, D. (2000). Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. Transp-lantation, 70: 1718.
Knight, M., Workman, M., Fitzpatrick, K., Acosta, C., Peirsegaele, P., Mistry, V., Kurinczuk, J.J. (2013). UK Obstetric Surveillance System Annual Report 2013. Oxford: National Perinatal Epidemiology Unit. Erişim Tarihi: 13.01.2014.
https://www.npeu.ox.ac.uk/downloads/files/ukoss/a nnual-reports/UKOSS-Annual-Report-2013.pdf Lessan-Pezeshki, M., Ghazizadeh, S., Khatami, M.R.
Mahdavi, M., Razaqhi, E., Seifi, S., Ahmadi, F., Maasar, S. (2004). Fertility and contraceptive issues after kidney transplantation in women. Transplant Proc, 36:1405–6.
Mattix Kramer, H.J., Tolkoff-Rubin, N.E., Williams, W.W., Cosimi, A.B., Pascual, M.A. (2003).
Reproductive and contraceptive characteristics of premenopausal kidney transplant recipients. Prog Transplant, 13:193–6.
Matuszkiewicz-Rowinska, J., Skorzewska, K., Radowicki, S., Niemczyk, S., Sokalski, A., Przedlocki, J. (2004). Endometrial morphology and pituitarygonadal axis dysfunction in women of reproductive age undergoing chro-nic haemodialysis–a multicentre study. Nephrol Dial Transplant, 19(8): 2074-2077.
Mazziotti, G., Angeli, A., Bilezikian, J.P., Canalis, E., Giustina, A. (2006). Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab, 17:144–9.
McKay, D.B., Adams, P.L., Bumgardner, G.L., Davis, C.L., Fine, R.N., Krams, S.M., Martinez, O.M., Pavlakis, M., Tolkoff-Rubbin, N., Sheman, M.S., Josephon, M.A. (2006) Reproduction and pregnancy in transplant recipe-ents: current practices. Prog Transplant, 16(2):127-132.
McKay, D. B., Josephson, M. A., (2005). Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation. Am J Transplant 2005;5(7): 1592–9.
McKay, D. B., M. A. Josephson (2006). Pregnancy in recipients of solid organs effects on mother and child. N Engl J Med, 354(12): 1281-93.
Murray, J. E. (2011). Edith Helm (April 29, 1935-April 4, 2011): The world’s longest surviving transplant recipient. Am J Transplant, 11(7): 1545-1546.
National Transplantation Pregnancy Registry–NTRP. (2011). Annual Report, Thomas Jefferson University. pp: 1-22. Erişim Tarihi: 13.01.2014. http://ntpr.giftoflifeinstitute.org.
Ortiz, M. E., Croxatto, H. B. (2007). Copper-T intrauterine device and levonorgestrel intrauterine system: biological bases of their mechanism of action. Contraception, 75:S16–S30.
Parhar, K. S., Gibson, P. S., Coffin, C. S. (2012). Pregnancy following liver transplantation: Review of outcomes and recommendatios for management, Can J Gastroenterol, 26(9); 621-626
Paulen, M. E., Folger, S. G., Curtis, K. M., Jamieson, D. (2010). Contraceptive use among solid organ transplant patients: a systematic review, Contraception, 82: 102-112
Pietrzak, B., Bobrowska, K., Jabiry-Zieniewicz, Z., Kaminski, P., Wielgos, M., Pazik, J., Durlik, M. (2007). Oral and transdermal hormonal contraception in women after kidney transplantation. Transplant Proc, 39:2759–62.
Pietrzak, B., Wielgos, M., Kaminski, P., JabiryZieniewicz, Z., Bobrowska, K. (2006). Menstrual cycle and sex hormone profile in kidneytransplanted women. Neuro Endocrinol Lett, 27(1-2): 198- 202.
Seidegard, J., Simonsson, M., Edsbacker, S. (2000). Effect of an oral contraceptive on the plasma levels of budesonide and prednisolone and the influence on plasma cortisol. Clin Pharmacol Ther, 67: 373–81.
Shaker, J. L, Lukert, B. P. (2005). Osteoporosis associated with excess glucocorticoids. Endocrinol Metab Clin North Am, 34:341–349.
Sibanda, N., Briggs, D., Davison, J.M., Johnson, R., Rudger, C. (2007). Pregnanacy after organ transplantation (a report from U.K. Transplant pregnancy registry Transplantation, 83(10); 1301-1307.
T.C. Sağlık Bakanlığı, Sağlık Hizmetleri Genel Müdürlüğü, Organ, Doku ve Diyaliz Hizmetleri Daire Başkanlığı Bilgi Sistemleri Yönetimi ve Denetimi Birimi, web adresi: bagis@saglik.gov.tr, e-posta: bilgisistemleriyonetimi@gmail.com
Ville, Y., Fernandez, H., Samuel, D., Bismuth, H., Frydman, R. (1993). Pregnancy in liver transplant recipients: course and outcome in 19 cases. Am J Obstet Gynecol, 168: 896-902.
American Academy of Pediatrics, Committee in Drugs, The transfer of drugs and other chemicals into human milk (2001). Pediatrics, 108: 776-89.
Watnick, S., Rueda, J. (2008). Reproduction and contraception after kidney transplantation. Curr Opin Obstet Gynecol, 20:308–12.
Wu, A., Nashan, B., Messner,U., Schmidt, H. H., Guenther, H. H., Niesert, S., Pichmayr, R. (1998). Outcomes of 22 successful pregnancies after liver transplantation. Clin Transplant, 12: 454-464.
Zheng, S., et all. (2013). Tacrolimus placental transfer at delivery and neonatal exposure through breast milk. Br J Clin Pharmacol, 76(6):988-96.
Ramhendar, T., Byrne, P. (2013). Contraception for renal transplant recipients in the Republic of Ireland: a review. Ir J Med Sci, 182: 315-317.
Walcott, W. O., Derick, D. E., Jolley, J. J., Snyder, D. L. (1978). Successful pregnancy in a liver transplant patient. Am J Obstet Gynecol, 132: 340-341.
Dünya Sağlık Örgütü, World Health Organization (2010). Medical Eligibility Criteria for Contraceptiev Use, 4th Edition.
Yıldırım, Y., Uslu, A. (2005). Pregnancy in patients with previous successful renal transplantation. International Journal of Gynecology & Obstetrics. 90(3); 198-202.
Krajewski, C. M., Geetha, D., Gomez-Lobo, V. (2013). Contraceptive Options for Women With a History of Solid Organ Transplantation. Transplantation, 95(10); 1183-1186
Josephon, M. A., McKay D. B. (2013). Women and transplantation: fertility, sexuality, pregnacy, contraception. Advances in Chronic Kidney Disease. 20(5): 433-440.