Seksual Siklus Süresince İnek Tuba Uterinasında ErbB1/HER1 ile ErbB2/HER2 Reseptörlerinin Dağılımı

Tuba uterina, memeli üremesinde çok önemli bir rol oynar ve oosit olgunlaşması, sperm kapasitasyonu, döllenme ve gamet ve embriyoların taşınması için en uygun ortamı sağlar. ErB ailesi reseptörlerinin tuba uterinanın fonksiyonlarında etkili olduğu düşünülmektedir. Birçok araştırmacı ErbB1/HER1 ve ErbB2/HER2 reseptörlerinin seksual ya da menstrual siklus süresince tuba uterinanın luminal epitel, bağdoku ve düz kas hücrelerinden değişen yoğunluklarda ekspresse olduğunu göstermişlerdir. Sunulan çalışmada, erbB1/HER1 ve erbB2/HER2 reseptörlerinin ekspresyonu immunohistokimyasal olarak incelendi. Bu çalışmada 23 farklı holştayn ineğin ovaryum, uterus ve tuba uterinadan doku örnekleri alındı. Sonuç olarak, seksual siklus süresince erbB1/HER1 ve erbB2/HER2 reseptörlerinin inek tuba uterinasında hücre tiplerine göre değişen yoğunluklarda lokalize olması, bu reseptörlerin inek tuba uterinasında önemli fizyolojik etkilere sahip olabileceğini akla getirdi.

Anahtar Kelimeler:

tuba uterina, ErbB1/HER1, ErbB2/HER2

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