Emin KARAKURT, Serpil DAG, Hilmi NUHOĞLU, Mushap KURU, Hasan ORAL, Enver BEYTUT, Ayfer YILDIZ

Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas

The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasis capacity in various mammary carcinomas subtypes observed in dogs immunohistochemically with PCNA and MMP-9 markers. The material of this study consisted of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of 8.4 years brought to our department between 2012 and 2020. 4 of 10 mammary carcinoma cases were classified as intraductal papillary carcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA and MMP-9 positive cells in solid subtype. In conclusion, there may be a positive relationship between cell proliferation, invasion and metastasis capacity under the solid subtype.

Köpek Meme Karsinomlarında PCNA ve MMP-9 Ekspresyonlarının İmmunohistokimyasal Olarak Değerlendirilmesi

Bu çalışmanın amacı, köpeklerde görülen çeşitli meme karsinomu alt tiplerinde hücre proliferasyonu ile invazyon-metastaz kapasitesi arasında anlamlı bir ilişki olup olmadığını PCNA ve MMP-9 gibi immunohistokimyasal belirteçler aracılığıyla ortaya koymaktır. Bu çalışmanın materyali, 2012-2020 yılları arasında anabilim dalımıza getirilen yaş ortalaması 8,4 yıl olan 6 Kangal ve 4 Setter köpeğinden alınan meme kanseri doku örnekleri oluşturdu. 10 meme karsinomu vakasından 4'ü intraduktal papiller karsinom, 4'ü miks karsinom, 1'i solid karsinom ve 1'i tübüler karsinom olarak sınıflandırıldı. Solid alt tipte en yüksek ortalamada PCNA ve MMP-9 pozitif hücre sayısı bulundu. Sonuç olarak sadece solid alt tipte hücre proliferasyonu ile invazyon ve metastaz kapasitesi arasında pozitif bir ilişki olabileceği kanısına varıldı.

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