Gamze ÖZTÜRK, Müzeyyen ASLANER AK, Sehmus ERTOP

The Association Between Weight Loss and Platelet Markers in Morbidly Obese Patients

Objective: To examine the association of weight loss achieved through obesity treatment with platelet number and markers (mean platelet volume, MPV; plateletcrit, PCT; platelet/lymphocyte ratio, PLR; and platelet distribution width, PDW) in morbidly obese patients. Methods: A total of 300 patients diagnosed with morbid obesity between 2017 and 2019 were included in this retrospective study. Weight at baseline and 6 months, body mass index (BMI), complete blood count (platelet, lymphocyte, plateletcrit, platelet/lymphocyte ratio, and platelet distribution width), and demographic data were evaluated. Results: A total of 300 morbidly obese patients with a BMI ≥ 40 kg/m2 were included. A weight loss of ≥ 10% was considered “significant”, and a weight loss of

Keywords:

morbid obesity plateletcrit, mean platelet volume, body mass index,

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1. Leitner DR, Frühbeck G, Yumuk V, et al. Obesity and type 2 diabetes:Two diseases with a need for combined treatment strategies-EASO can lead the way. Obes Facts. 2017; 10: 483-92.
2. Rueda- Clausen CF, Ogunleye AA, Sharma AM. Health benefits of long-term weight-loss maintenance. Annu Rev Nutr. 2015; 35: 475-516
3. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002; 288: 1723-7.
4. Samur G, Yıldız E. Obezite ve kardiyovasküler hastaliklar/hipertansiyon Sağlık Bakanlığı Yayın 2008.
5. Nording H, Langer HF. Complement links platelets to innate immunity. Seminars in immunology. 2018; 37: 43-52.
6. Mutlu H , A rtış T A, E rden A , et al. Alteration in mean platelet volume and platicrit values in patients with cancer that developed thrombosis. Clinical and Applied Thrombosis/Hemostasis. 2013; 19: 331-3.
7. Gasparyan YA, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume:a link between thrombosis and inflammation. Current Pharmaceutical Design. 2011; 17: 47-58.
8. Morange PE, Alessi MC. Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology. Thromb Haemost. 2013; 110: 669-80. 9. Coutinho T, Goel K, Corrêa de S á D, et al. Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data. J Am Coll Cardiol. 2011; 57: 1877-86.
10. Borch KH, Nyegaard C, Hansen JB, et al. Joint effects of obesity and body height on the risk of venous thromboembolism: The Tromsø Study. Arteriosclerosis, Thrombosis and Vascular Biology. 2011; 31: 1439–44.
11. Butkiewicz AM, Kemona H, Dymicka-Piekarska V, et al.Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thrombosis Research. 2006; 118: 199-204.
12. Samocha-Bonet D, Justo D, Rogowski O, et al. Platelet counts and platelet activation markers in obese subjects. Mediators of inflammation 2008.
13. Lebedeva EV,Yushkov BG, Chereshnev VA. Megakaryocytopoiesis under hypoxic conditions. Bulletin of Experimental Biology and Medicine. 2003; 136: 554-6.
14. Greisenegger S, Endler G, Hsieh K, et al. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events. Stroke. 2004; 35: 1688–91.
15. Çoban E, Özdoğan M, Yazıcıoğlu G, et al. The mean platelet volume in patients with obesity. Int J Clin Pract. 2005; 59: 981-2.
16. Furman-Niedziejko A, Rostoff P, Rychlak R, et al. Relationship between abdominal obesity, platelet blood count and mean platelet volume in patients with metabolic syndrome. Folia Med Cracov. 2014; 54: 55-64.
17. Toplak H, Sagmeister E, Wascher TC. Cardiovascular risk factors in obesity. The effect of weight reduction on platelet size in overweight patients. International Journal of Obesity and Related Metabolic Disorders:Journal of the International Association for the Study of Obesity. 1994; 18: 355-6.
18. Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010; 14: 28–32.
19. Wang R-t, Jin D, Li Y, et al. Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and Alzheimer's disease. Journal of Psychiatric Research. 2013; 47: 644-9.
20. Gupta S, Saxena SK, Lalchandani A, et al. Significance of platelet volume indices in patients of coronary artery diseases (CAD) and acute myocardial infarction (mi): a new predictor for Ihd. Indian Journal of Cardiology. 2012; 15; 22-5.
21. Akpinar I, Sayın MR, Gursoy YC, et al. Plateletcrit and red cell distribution width are independent predictors of the slow coronary flow phenomenon. Journal of Cardiology. 2014; 63: 112-8.
22. Furuncuoğlu Y, Tulgar S, Dogan AN, et al. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immuneinflammatory index and platelet indices: a retrospective study. European Review for Medical and Pharmacological Sciences. 2016; 20: 1300-6.
23. Erdal E, İnanir M. Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity. Rev. Assoc. Med. Bras. 2019; 65: 1182-7.
24. Gunaldi M, Göksu S, Erdem D, et al. Prognostic impact of platelet/lymphocyte and neutrophil/lymphocyte ratios in patients with gastric cancer: a multicenter study. Int J Clin Exp Med. 2015; 8: 5937–42.
25. Nemli H, Kısakol G, Küçüksaraç Kıyıcı SD, Güçlü M, Koca N. Effect of surgical weight loss on the inflammatory hematological parameters in short term. In 20th European Congress of Endocrinology. BioScientifica. 2018.