Evaluation of caregiver burden and quality of life in metastatic prostate cancer patients; Effects of clinical and socioeconomic factors

Objective: To investigate the caregiver burden and quality of life (QoL) of patients with metastatic prostate cancer and, to evaluate the relationship between questionnaire results and medical, socioeconomic, disease and treatment related factors of the patients. Methods: One hundred twenty one metastatic prostate cancer patients, and caregivers were enrolled in this cross-sectional study. Patients with metastatic prostate cancer who had at least one bone, lymph node or visceral metastasis who had undergone androgen deprivation or chemotherapy treatments for at least 3 months were included. Short Form 36 (SF-36) questionnaires and Zarit caregiver burden interviews (ZCBI) were conducted with patients and their caregivers seperately. Patients’ disease, treatment, socioeconomic and caregiver related factors were recorded respectively. Results: Patients’ comorbidities, ECOG score, presence and quantity of bone or visceral metastasis, bone related events, receiving palliative radiotherapy and chemotherapy, using public transportation resulted in lower SF-36 and higher ZCBI results (p

Keywords:

Caregiver burden, quality of life, prostate cancer,

PDF

___

1. Burckhardt CS, Woods SL, Schultz AA, Ziebarth DM. Quality of life of adults with chronic illness: A psychometric study. Res Nurs Health. 1989; 12: 347–54.
2. Buyan N, Türkmen MA, Bilge I, et al. Quality of life in children with chronic kidney disease (with child and parent assessments). Pediatr Nephrol. 2010; 25: 1487-96.
3. Rahmani F, Ranjbar F, Hosseinzadeh M, et al. Coping strategies of family caregivers of patients with schizophrenia in Iran: A cross-sectional survey. Int J Nurs Sci. 2019; 6: 148–53.
4. Mora-Castañeda B, Márquez-González M, Fernández-Liria A, de la Espriella R, Torres N, Arenas Borrero Á Clinical and demographic variables associated coping and the burden of caregivers of schizophrenia patients. Rev Colomb Psiquiatr. 2018; 47: 13–20.
5. Parekh NK, Shah S, McMaster K, et al. Effects of caregiver burden on quality of life and coping strategies utilized by caregivers of adult patients with inflammatory bowel disease. Ann Gastroenterol. 2017; 30: 89-95.
6. Cooper C, Katona C, Orrell M, Livingston G. Coping strategies, anxiety and depression in caregivers of people with Alzheimer's disease. Int J Geriatr Psychiatry. 2008; 23: 929–36.
7. Johansen S, Cvancarova M, Ruland C. The effect of cancer patients' and their family caregivers' physical and emotional symptoms on caregiver burden. Cancer Nurs. 2018; 41: 91–99.
8. Semere W, Althouse AD, Rosland AM, et al. Poor patient health is associated with higher caregiver burden for older adults with advanced cancer. J Geriatr Oncol. 2021; 5: 771-8.
9. Crowder SL, Najam N, Sarma KP, Fiese BH, Arthur AE. Quality of life, coping strategies, and supportive care needs in head and neck cancer survivors: a qualitative study. Support Care Cancer. 2021; 8: 4349-56.
10. Guan T, Santacroce SJ, Chen DG, Song L. Illness uncertainty, coping, and quality of life among patients with prostate cancer. Psychooncology. 2020; 29: 1019–25.
11. Wang L, Paller CJ, Hong H, et al. Comparison of Systemic Treatments for Metastatic Castration- Sensitive Prostate Cancer: A Systematic Review and Network Meta-analysis. JAMA Oncol. 2021; 3: 412- 20.
12. Palumbo C, Bruni A, Antonelli A, et al.; Pros-IT CNR Study Group. Health-related quality of life 24- month after prostate cancer diagnosis: an update from the Pros-IT CNR prospective observational study. Minerva Urol Nefrol. 2021;1. Epub ahead of print. PMID: 33439570.
13. American Diabetes Association. 11. Older Adults. Diabetes Care. 2017; 1: 99-104
14. McHorney CA, Ware Jr JE, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 1993; 31: 247–63.
15. Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feeling of burden. Gerontologist 1980; 20: 649–55.
16. Özlü A, Yıldız M, Aker T. A reliability and validity study on the ZCBI caregiver burden scale. Archives of Neuropsychiatry 2009; 46: 38–42
17. Heidenreich A, Pfister D, Porres D. Cytoreductive radical prostatectomy in patients with prostate cancer and low volume skeletal metastases: results of a feasibility and case-control study. J Urol. 2015; 193: 832–8.
18. Tosoian JJ, Gorin MA, Ross AE, et al. Oligometastatic prostate cancer: definitions, clinical outcomes, and treatment considerations. Nat Rev Urol. 2017; 14: 15–25.
19. Erim DO, Bennett AV, Gaynes BN, et al. Associations between prostate cancer-related anxiety and health-related quality of life. Cancer Med 2020; 9: 4467–73.
20. Uemura H, DiBonaventura M, Wang E, et al. The treatment patterns of castration-resistant prostate cancer in Japan, including symptomatic skeletal events and associated treatment and healthcare resource use. Expert Rev Pharmacoecon Outcomes Res 2017; 17: 511–7.
21. Ferro M, Lucarelli G, Crocetto F, et al. First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings. Crit Rev Oncol Hematol. 2021; 157: 103-198.
22. Brust JD, Leonard BJ, Sielaff BH. Maternal time and the care of disabled children. Public Health Nurs. 1992; 9: 177–184.
23. Soen S, Usuba K, Crawford B, Adachi K. Family caregiver burden of patients with osteoporotic fracture in Japan. J Bone Miner Metab. 2021; 4: 612- 22.
24. Faronbi JO. Correlate of burden and coping ability of caregivers of older adults with chronic illness in Nigeria. Scand J Caring Sci. 2018; 32: 1288– 96.
25. Srivastava G, Tripathi RK, Tiwari SC, Singh B, Tripathi SM. Caregiver Burden and Quality of Life of Key Caregivers of Patients with Dementia. Indian J Psychol Med. 2016; 38: 133–6.
26. Jafari H, Ebrahimi A, Aghaei A, Khatony A (2018) The relationship between care burden and quality of life in caregivers of hemodialysis patients. BMC Nephrol 19: 321.
27. McKay R, Haider B, Duh MS, et al. Impact of symptomatic skeletal events on health-care resource utilization and quality of life among patients with castration-resistant prostate cancer and bone metastases. Prostate Cancer Prostatic Dis. 2017; 20: 276–82.