Ghrelin; gündemdeki hormon

Ghrelin, büyüme hormonu salgılatıcı etkisi olan, enerji dengesi ve besin alınımının düzenlenmesinde rol oynayan 28 aminoasitli bir hormondur. Başlıca midenin oksintik bezlerinde bulunan özelleşmiş A-benzeri hücreleri tarafından kan akımına salınır ancak daha düşük düzeylerde olmak üzere, vücudun diğer birçok bölgesinden salındığı da gösterilmiştir. Ghrelin hormonunun birçok fonksiyonlara sahip olduğu, yapılan deneysel çalışmalardan anlaşılmış bulunmaktadır.

Ghrelin; The renown hormone

Ghrelin , a 28 amino acid gastric peptide, was found to be a potent releaser of GH and in addition, actively participate in controlling energy balance and the regulation of food intake. Specifically, plasma ghrelin originates in the oxyntic gland where A-like cells exist and is secreted into the bloodstream. Lower concentrations have also been reported at various regions in the body. It is well known that ghrelin participates in the regulation of many functions in the body

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  • 1. Kojima M, Hosoda H,Date Y: Ghrelin is a growth-hormone-releasing acylatedpeptide from stomach. Nature,1999;402:656- 660.
  • 2. Casanueva FF, Dieguez C: Ghrelin; The link connecting growth with metabolism and energy homeostasis. Reviews in Endocrine Disorders,2002;3:325-338.
  • 3. Hosoda H, Kojima M, Matsuo H, Kangawa K: Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor . J Biol Chem,2000; 29:1995- 2000.
  • 4.Tanaka M, Hayashida Y, Nakao N, Nakai N, Nakashima K: Testis-spesific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochem Biophys Acta, 2001; 1522: 62- 65.
  • 5.Bowers CY, Momany F,Reynolds GA, Chang D, Hong A, Chang K: Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro.Endocrinol, 1980;106:663-667.
  • 6. Korbonits M, Bustin SA, Kojima M: The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pitiutary and other neuroendocrine tumors. J Clin Endocrinol Metab, 2001; 86: 881- 887.
  • 7. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI et al: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science, 1996; 273: 974- 977.
  • 8. Petersenn S: Structure and regulation of the growth hormone secretagogue receptor. Minerva Endocrinol,2002; 27:243-256.
  • 9. Ghigo E, Avrat E, Broglio F, Giordano R, Gianotti L, Muccioli G et al: Endocrine and non-endocrine activities of growth hormone secretagogues in humans. Horm.Res.,1999; 51:9-15.
  • 10. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T et al: Stomach is a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immuno reactivity levels in humans. Journal of Clinical Endocrinology and Metabolism, 2001; 86: 4753- 4758.
  • 11. Barreiro ML, Gaytn F,Caminos JE: Cellular location and hormonal regulation of ghrelin expression in rat testis. Biol Reprod,2002a; 67: 1768 -1776.
  • 12. Sleisenger C, Foltran B. Gastrointestinal and Liver Disease: WB Saunders7th ed., 2002.
  • 13. Volante M, Allia E, Gugliotta P: Expression of ghrelin and GHS reseptor by pankreatic islet cells and related endocrine tumors.J Clin Endocrinol Metab, 2002a:87:1300-1308.
  • 14. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M: Ghrelin and the regulation of energy balance- a hypothalamic perspective (Review). Endocrinology, 2001; 142: 4163- 4169.
  • 15. Tolle V, Bassant MH, Zizzari P: Ultradian rhythmicity of ghrelin secration in relation GH, feeding behaviour and sleep-wake patterns in rats. Endocrinology, 2002:143: 1353 -1361.
  • 16. Gaskin F.S, Farr S.A, Banks WA, Kumar VB, Morley JE: Ghrelin-induced feeding is dependent on nitric oxide. Peptides, 2004; 24: 913- 918.
  • 17. Inui A: Ghrelin an somatotrophic signal from the stomach. Nat Rev Nuerosci, 2001; 2: 551- 560.
  • 18. Asakawa A, Inui A, Kaya T: Ghrelin is an appetide-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology, 2001; 120:337- 345.
  • 19. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H et al: The role of gastric vagal afferent in feeding and growth hormone secretion effects of ghrelin. Gastroenterology,2002; 123:1121- 1128.
  • 20. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, et al: Upregulation of ghrelin expression in the stomach upon fasting,insulin induced hypoglycemia and leptin administration. Biochem. Biophys. Res. Commun,2001; 281:1220- 1225.
  • 21. Shintani M,Ogawa Y,Ebihara K: Ghrelin, an endogenous growth hormone secretagogue is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes, 2001; 50:227-232.
  • 22. Krsek M, Rosicka M, Haluzik M, Svobodova J, Kotrlikova E, Justova V et al. Plasma ghrelin levels in patients with short bowel syndrome. Endocr Res, 2002; 28: 27-33.
  • 23. Nagaya N, Kojima M, Uematsu M: Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol, 2001;280:1483- 1487.
  • 24.Ghigo E, Arvat E, Giordano R: Biologic activities of growth hormone secretagogues in humans. Endocrine,2001;14:87-93.
  • 25. Wiley KE, Davenport AP: Comparison of vasodilators in human internal mammary artery; ghrelin is a potent physiological antagonist of endotelin-1. Br J Pharmacol, 2002; 136:1146-1152.
  • 26. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JE et al: Novel expression and functional role for ghrelin in rat testis. Endocrinology,2002; 143:717- 725.
  • 27. Tanaka K,Minoura H, Isobe T, Yonaha H, Kawato H, Wang DF et al: Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab,2003; 88: 2335- 2340.
  • 28. Kojima M, Hosoda H, Matsuo H, Kangawa K: Ghrelin; discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.Trends in Endocrinology and Metabolism,2001; 12:118-122.
  • 29. Chopin LK, Veveris-Lowe TL, Philipps AF, Herington AC : Co-expression of GH and GHR isoforms in prostate cancer cell lines. Growty Horm IGF Res,2002; 12: 126.
  • 30. Kim K, Arai K, Sanno N, Osamura RY, Teramoto A, Shibasaki T: Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas. Clin Endocrinol (Oxf),2001; 54: 759- 768.
  • 31. Duxbury MS, Waseem T, Ito H, Robinson MK, Zinner MJ, Ashley SW et al: Ghrelin promotes pankreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun,2003; 309:464- 468.
  • 32. Enomoto M, Nagaya N, Uematsu M, Okumura H, Nakagawa E, Ono F, et al: Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel GHR-P, in healthy humans. Clin Sci,2003;10.