Evaluation of Nosocomial Infections in Reanimation Intensive Care Unit: Analysis of Six Years Surveillance

Objective: Nosocomial infections (NI) raise costs due to the increased in mortality and long-term hospitalization. There are more NIs in intensive care units (ICU) probably due to invasive procedures. In order to reduce NIs, the most important step in terms of prevention is the identification of the common pathogens with their infection rates among these units. For this purpose, the centers should conduct surveillance studies and often evaluate their data. Methods: We evaluated the infection rates and ratios, between January 1st, 2014 and August 31st, 2019 in Reanimation Intensive Care Unit (ICU) in our hospital. Method of the surveillance was, prospective, active, laboratory and patient based. Results: In our reanimation ICU, 1591 patients were followed up during the study period. 192 NIs were observed in 179 patients on 21,840 intensive care days. NI rate was found to be 11.25 and Infection density rate was found to be 8.20 and their change over the years was examined. Analysis regarding the source of infections revealed that ventilator-related pneumonia (27.08%) and central venous catheter-related blood-stream infection (25.52%) was most commonly observed during the study period. The ventilator usage rate was 0.54 (11.859 ventilator days) and the central venous catheter usage rate was 0.94 (20.566 catheter days) in the study period. Acinetobacter baumannii (n = 96, 50%), Pseudomonas aeruginosa (n = 24, 12.5%) and Klebsiella pneumonia (n = 18, 9.38%) were most commonly isolated.

Reanimasyon Yoğun Bakım Ünitesinde Gelişen Nozokomiyal Infeksiyonların Değerlendirilmesi: Altı Yıllık Sürveyans Verilerinin Analizi

Amaç: Nozokomiyal enfeksiyonlar (NE) artmış mortalite ve uzayan yatışlar sonucu maliyet artışına sebep olurlar. Özellikle uygulanan invaziv girişimlere bağlı olarak oranlar yoğun bakım ünitelerinde (YBÜ) daha yüksektir. NE’leri azaltabilmek için merkezlerin daha ötesi ünitelerin kendi enfeksiyon oranlarını izlemesi sık görülen patojenleri bilmesi yapılacak önleme faaliyetleri açısından en önemli basamaktır. Bu amaçla merkezler sürveyans çalışmaları yürütüp verilerini düzenli olarak değerlendirirler. Yöntemler: Bu çalışmada 1 Ocak 2014 – 31 Ağustos 2019 tarihleri arasında hastanemiz Reanimasyon YBÜ‘nün enfeksiyon hızları ve oranları değerlendirilmiştir. Çalışma, laboratuar ve hasta temelli olarak yürütülen aktif sürveyans verileri prospektif olarak incelenmiştir. Bulgular: Sonuç olarak çalışma döneminde reanimasyon yoğun bakım ünitemizde 1591 hasta takip edilmiştir, 21.840 yoğun bakım gününde 179 hastada 192 NE atağı izlenmiştir. NE hızı:11,25; Enfeksiyon dansite hızı: 8.20 olarak bulunmuş ve yıllara gore değişimi incelenmiştir. Tüm çalışma boyunca İnvaziv alet ilişkili enfeksiyon oranları değerlendirildiğinde, %27,08’i ventilator ilişkili pnömoni, %25,52’si santral venöz kateter enfeksiyonu olarak bulundu. Çalışma döneminde ünitedeki ventilator kullanım hızı:0,54 (11.859 ventilatör günü) ve santral venöz kateter kullanım oranı: 0,94 (20.566 kateter günü) olarak hesaplanmıştır. En sık olarak üreyen etken yıllara göre değişmekle birlikte toplamda Acinetobacter baumannii (n=96, %50), Pseudomonas aeruginosa (n=24, %12,5), Klebsiella pneumonia (n=18, %9,38), Candida spp. (n=20, 10,4%) izole edilmiştir.

___

1. Sheng WH, Wang JT, Lin MS, et al. Risk factors affecting inhospital mortality in patients with nosocomial infections. J Formos Med Assoc. 2007; 106: 110-8.

2. Akalın H. Infections in intensive care units: risk factors and epidemiology. Turk J Hosp Infect. 2001; 5: 5-16.

3. Eggiman P, Pillet D - Infection control in the ICU. Chest Journal, 2001; 120: 2059-93.

4. Çağatay Atahan A, Özsüt H. Infections and antimicrobial therapy in intensive care unit. Yoğun Bakım Dergisi. 2001; 1: 21-32.

5. Khan HA, Baig FK, Mehboob R. Nosocomial infections: epidemiology, prevention, control and surveillance. Asian Pac J Trop Biomed. 2017; 7: 478– 82.

6. Celen MK, Tamam Y, Hosoglu S, et al.Multiresistant bacterial colonization due to increased nurse workload in a neurology intensive care unit. Neurosciences. 2006; 11: 265-70.

7. CDC, Guidelines & Guidance Library https://www.cdc.gov/infectioncontrol/guidelines/ index.html (accessed on 10th September 2019).

8. Guidelines for the Prevention of Intravascular Catheter-Related Infections (2011) https://www.cdc.gov/infectioncontrol/pdf/guideli nes/bsi-guidelines-H.pdf

9. National Healthcare Safety Network. Deviceassociated module ventilator-associated event (VAE); Centers for Disease Control and Prevention website. 2017. http://www.cdc.gov/nhsn/pdfs/pscManual/10- VAE_FINAL.pdf (accessed on 10th September 2019).

10. M. Nguile-Makao, R. Zahar, A. Français, et al. Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models. Intensive care medicine, 2010; 36: 781–9.

11. Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Twenty-third Informational Supplement. M100-S23, CLSI Vol 34, No:1, 2014. Wayne, PA (accessed on 10th September 2019).

12. Garner JS, Jarvis WR, Emori TG, et al. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16: 128-40.

13. Bueno-Cavanillas A, Delgado-Rodriguez M, Lopez-Luque A, et al. Influence of nosocomial infection on mortality rate in an intensive care unit. Crit Care Med. 1994; 22: 55-60.

14. Vincent JL, Bihari DJ, Suter PM, et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA. 1995; 274: 639-44.

15. Saba R. Supportive measures in ICU patients: which patients have to be isolated? J Intens Care 2002; 2: 133-8.

16. Esen S, Leblebicioglu H. Prevalence of nosocomial infec¬tions at intensive care units in Turkey: a multicentre 1-day point prevalence study. Scand J Infect Dis. 2004; 36: 144-8.

17. Tekeli E. ICU infections of yesterday, today and tomorrow. J Intens Care. 2002; 2: 9-13.

18. T. Adnan, T. Recep, D. Tuba, et al. Evaluation of hospital infections developing in intensive care unit during a decade and review of literatüre. Dicle medi j. 2012; 39: 492-8

19. F. G. Mehmet, H. Salih, A. Celal, et al. Surveillance of Nosocomial Infections in Dicle University Hospital: A Ten-Year Experience. Turk J Med Sci. 2008; 38: 587-93.

20. D. Necla, O. Esra, D. Semih, et al. Three-year evaluation of nosocomial infection rates of the ICU. Rev. Bras. Anestesiol. 2013; 63: 73-84.

21. İnan D, Saba R, Yalcin AN, et al. Device-associated nosocomial infection rates in Turkish medicalsurgical intensive care units. Infect Control Hosp Epidemiol. 2006; 27: 343-8.

22. C. Aslıhan, K. Behice, K. Filiz, et al. Invasive Device-Associated Nosocomial İnfections of A Teaching Hospital in Turkey; Four Years’ Experience. Turk J Med Sci. 2011; 41: 137-47.

23. Rosenthal VD, Maki DG, Salomao R, et al. Deviceassociated nosocomial infections in 55 intensive care units of 8 developing countries. Ann Intern Med. 2006; 145: 582-91.

24. Z. Eyal, H. Daniel, T. Orly, et al. Health Care– Associated Infections A Meta-analysis of Costs and Financial Impact on the US Health Care System. JAMA Intern Med. 2013; 173: 2039-46.

25. Raoof S and Baumann MH. Ventilator-Associated Events: The New Definition. Am J Crit Care. 2014; 23: 7-9.

26.Wunderink RG, Woldenberg LS, Zeiss J, et al. The radiologic diagnosis of autopsy-proven ventilatorassociated pneumonia. Chest. 1992; 101: 458-63.

27. G. Raeley, V. Jarin, C.B. Jorge, et al. Risk Factors for Ventilator-Associated Events in a PICU. Pediatric Critical Care Medicine. 2018; 19: 7–13.

28. Fàbregas N, Ewig S, Torres A, et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax. 1999; 54: 867- 73.

29. Johanson WG Jr, Pierce AK, Sanford JP, et al. Nosocomial respiratory infections with gramnegative bacilli: the significance of colonization of the respiratory tract. Ann Intern Med. 1972; 77: 701- 6.

30. Süner A, Karaoğlan İ, Mete AO, et al. Assessement of bloodstream infections and risk factors in an intensive care unit. Turk J Med Sci. 2015; 45: 1243- 50.

31. Ç. Saliha, B. Vuslat, N. Mustafa, et al. Invasive device-associated hospital infection rates, etiological agents, and their antibiotic susceptibilities in the medical intensive care unit of a university hospital in Turkey. Turk J Med Sci. 2013; 43: 33-8.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
Sayıdaki Diğer Makaleler

Investigation of the Association between Bispectral index and Body Temperature during Abdominal Surgery; An Observational Study

Çi̇ğdem AKYOL BEYOĞLU, Ceylan SAYGILI, Mustafa DILEK, Guniz Meyanci KOKSAL

Parkinson's Disease Profile – A 17-Year Patient Analysis

Ahmet ADIGUZEL, Unal OZTURK, Sibel ALTINAYAR

Can We Predict the Duration of Treatment Requirement by Complete Blood Count in Chronic Spontaneous Urticaria Patients Receiving Omalizumab?

Ebru CELIK, Emre DIRICAN

The Most Important Factors in Prognosis Of Obstetric Patients with Disseminated Intravascular Coagulation: A Tertiary Center Study

Abdulkadir TURGUT, Nurullah PEKER, Elif AGACAYAK, Gamze AKIN EVSEN, Edip AYDIN, Mehmet Sait ICEN, Talip KARACOR, FATİH MEHMET FINDIK, Feyzi CELIK, Emre DIRICAN, Talip GUL

Çocuklarda torakoport yardımlı laparoskopik apendektomi sonuçlarımız

Erol BASUGUY, M.Hanifi OKUR, Serkan ARSLAN, Bahattin AYDOĞDU, Sevinç AKDENİZ, MUSTAFA AZİZOĞLU

Psychological Stress of Healthcare Workers Caused by the COVID-19 Pandemic

Gülşen YALCIN, Bahattin SAYINBATUR, Eyaz KARAY, Merve KARAKAS

Evaluation Of Patients With Previous C/S + Plasenta Previa Totalis İn 2017

FATİH MEHMET FINDIK, Mehmet Sait ICEN, Senem Yaman TUNC, Elif AGACAYAK, Mehmet Siddik EVSEN, Ahmet YALINKAYA

Evaluation of Nosocomial Infections in Reanimation Intensive Care Unit: Analysis of Six Years Surveillance

Berna Kaya UGUR, Ayse Ozlem METE

Graves Olgularında Kardiyovasküler Hastalık Risk Değerlendirmesi: Trombosit İndekslerinin Rolü

HAKİM ÇELİK, Seyhan TAŞKIN, Adnan KİRMİT, Mehmet Ali EREN

Cerebral Hemodynamic Response To Menstrual Cycle In Migraine

Ayca OZKUL, Hasibe Ozgecen DINCEL, Ali AKYOL