Investigation of the Association between Bispectral index and Body Temperature during Abdominal Surgery; An Observational Study

Objective: Bispectral index (BIS) is mainly used for drug titration and is well correlated with drug concentration and hypnosis. Our aim was to present the correlation between hypothermia and BIS during abdominal surgery. Methods: The study was conducted in patients with American Society of Anesthesiologists (ASA) score I-III, aged between 18-60 y, who had undergone abdominal operation in general surgery theatre. Body temperature and BIS scores whenawake, after anesthesia induction, after tracheal intubation and every 5 minutes during the operation, and afterextubation were measured and recorded.Results: Three hundred patients were included to the study. Repeated measure regression analysis of BIS scores with the body temperature at distinct time points did not show a significant relationship. None of the patients had a body temperature lower than 35°C. Conclusions: As a result of our study, we can say that temperature decrease up to 35°C may not have an effect on BIS scores, and BIS maybe used safely to indicate hypnosis level at temperatures 35°C and above during abdominal surgery.

Batın Cerrahisinde Bispektral indeks ve Vücut Sıcaklığı arasındaki İlişkinin Araştırılması; Gözlemsel Çalışma

Amaç: Bispektral indeks’in (BIS) ilaç konstantrasyonları ve hipnoz ile olan ilişkisi dolayısıyla ilaç titrasyonu için sıklıkla kullanılmaktadır. Amacımız; batın cerrahisinde BIS ile hipotermi arasında bir ilişki olup olmadığını araştırmaktı. Yöntemler: Çalışma, Amerikan Anestezi Derneği Skoru (ASA) I-III arasında olan, 18-60 yaş arası batın cerrahisi geçiren hastalarda yapıldı. Hastaların vücut sıcaklığı ve BIS skoru uyanık iken, anestezi indüksiyonu sonrası, trakeal entübasyon sonrası ve entübasyondan sonra her 5 dakikada bir olmak üzere ölçüldü ve kaydedildi. Bulgular: Çalışmaya 300 hasta dahil edildi. Regresyon analizinde BIS ve vücut sıcaklığı arasında anlamlı bir ilişki saptanamadı. Çalışmadaki hiçbir hastanın vücut sıcaklığı 35°C’nin altında ölçülmedi. Sonuç: Sonuç olarak batın cerrahisinde 35°C’nin üzerindeki vücut sıcaklıklarında BIS, anestezi derinliğini güvenilir bir biçimde gösterebilir.

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1. Honan D , D oherty D , F rizelle H. A c omparison o f t he effects on bispectral index of mild vs. moderate hypothermia during cardiopulmonary bypass. Eur J Anaesthesiol 2006; 23: 385–90.

2. Bashein G, Nessly ML, Bledsoe SW, et al. Electroencephalography during surgery with cardiopulmonary bypass and hypothermia. Anesthesiology 1992; 76: 878–91.

3. Gökahmetoglu G, Tercan E, Bicer C, et al. Comparison of the depth of anesthesia in sevoflurane and halothane anesthesia with bispectral index and 95% spectral edge frequency Dicle Medical Journal 2013; 40: 350-6.

4. Chandran Mahaldar DA, Gadhinglajkar S, Sreedhar R. Sevoflurane requirement to maintain bispectral indexguided steady-state level of anesthesia during the rewarming phase of cardiopulmonary bypass with moderate hypothermia. J Cardiothorac Vasc Anesth 2013; 27: 59–62.

5. Mezrow CK, Midulla PS, Sadeghi AM, et al. Evaluation of cerebral metabolism and quantitative electroencephalography after hypothermic circulatory, arrest and low-flow cardiopulmonary bypass at different temperatures. J Thorac Cardiovasc Surg 1994; 107: 1006– 19.

6. Miyazaki R, Hoka S. What is the predictor of the intraoperative body temperature in abdominal surgery? J Anesth 2019; 33: 67–73.

7. Nguyen NT, Fleming NW, Singh A, et al. Evaluation of core temperature during laparoscopic and open gastric bypass. Obes Surg 2001; 11: 570–5.

8. McAllister RG. Effect of hypothermia on drug metabolism; in vitro studies with propranolol and verapamil. Pharmacology 1980; 20: 95–100.

9. Empey PE, Miller TM, Philbrick AH, et al. Mild hypothermia decreases fentanyl and midazolam steadystate clearance in a rat model of cardiac arrest. Crit Care Med 2012; 40: 1221–8.

10. Bjelland TW, Klepstad P, Haugen BO, et al. Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients. Drug Metab Dispos 2013; 41: 214–23.

11. Hostler D, Zhou J, Tortorici MA, et al. Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers. Drug Metab Dispos 2010; 38: 781–88.

12. Schmidlin D, Hager P, Schmid ER. Monitoring level of sedation with bispectral EEG analysis: Comparison between hypothermic and normothermic cardiopulmonary bypass. Br J Anaesth 2001; 86: 779–86.

13. Chandran Mahaldar DA, Gadhinglajkar S, Sreedhar R. Sevoflurane requirement to maintain bispectral indexguided steady-state level of anesthesia during the rewarming phase of cardiopulmonary bypass with moderate hypothermia. J Cardiothorac Vasc Anesth 2013; 27: 59–62.

14. Wang X, Zhang J, F eng K, et al. The effect of hypothermia during cardiopulmonary bypass on three electro-encephalographic indices assessing analgesia and hypnosis during anesthesia: consciousness index, nociception index, and bispectral index. Perfusion. 2020; 35: 154-62.

15. Miyazaki R, Hoka S. What is the predictor of the intraoperative body temperature in abdominal surgery? J Anesth 2019; 33: 67–73.

16. Nguyen NT, Fleming NW, Singh A, et al. Evaluation of core temperature during laparoscopic and open gastric bypass. Obes Surg 2001; 11: 570–75.

17. Moghadam MY, Shahi MN, Abadi BD, et al. Association Between Bispectral Index (BIS) Value and Postoperative Shivering in Patients Undergoing Orthopedic Surgery 2019; 15: 1166-9.

18. Chiang MH, Wu SC, HSU SW, et al. Bispectral Index and non-Bispectral Index anesthetic protocols on postoperative recovery outcomes. Minerva Anestesiologica 2018; 84: 216-28.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
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