Çocukluk çağı inmeleri

İnme, serebral arter ve venlerdeki ani tıkanma veya rüptür sonucunda ortaya çıkan fokal serebral hasardır. Tıkanma arteriyel veya venöz olabilir. Çocukluk çağında görülme riski 8–10.7/100 000 çocuk/yıldır. Hastalarda ani fokal nörolojik bulguların varlığı akla iskemiyi getirmelidir. İnmenin çocukluk çağında pek çok risk faktörü vardır, çocuklar akut dönem geçtikten sonra bu yönden de incelenmelidir. Çocukluk çağında inme tedavisi randomize çalışmalar olmadığı için erişkin literatürüne dayanmaktadır ve bu nedenle de tartışmalıdır

Stroke in childhood

Stroke is defined as a sudden occlusion or rupture of cerebral arteries or veins resulting in focal cerebral damage and clinical neurologic deficits. Occlusion can be arterial or venous. The incidence of pediatric stroke is 8–10.7/ 100.000 children / year. The risk factors in childhood stroke are multiple and should be detected after the acute state. Since there are not randomized controlled studies for childhood stroke treatment the treatment is still controversial and relies on adult literature.

PDF

___

1. de Veber G, Cerebrovascular Disease, In: Swaiman KF, Ashwal S., Ferriero DM eds.Pediatric Neurology, Principles and Practice, 4rd ed. St.Louis Mosby, 2006; 1759-1801.
2. Andrew M, Monagle PT, Brooker L. Ed. Tromboembolic complications during infancy and childhood. Hamilton, B.C. Decker Inc., 2000, 201-229.
3. Carlin TM, Chanmugam A. Stroke in children. Emerg Med Clin North Am 2002;3:671–85.
4. Uysal Z, Doğu F, Kürekçi AE, Deda G, et al. Recurrent arteial thrombosis in a child: Primary antiphospholipid antibody Syndrome. Ped Hem Oncol 2002; 19.59–66.
5. Akar N, Akar E, Deda G, et al. Factor V 1691 G-A, prothrombin 20210 G-A and methylenetetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct. J Child Neurol 1999; 14.749–51.
6. The National Institute of Neurologic Disorders and Stroke rt-PA, Stroke Study Group, 1995.
7. deVeber G. Arterial ischemic strokes in infants and children: An overview of current approaches. Semin Thromb Hemost 2003;29:567-73.
8. de Veber G, Andrew M. Canadian Pediatric Ischemic Stroke Study Group, Cerebral sinovenous thrombosis in children. N Eng J Med 2001;345: 417.
9. Pediatric Stroke Working Group. Stroke in Childhood: Clinical Guidelines for Diagnosis, Management and Rehabilitation, London: Royal College of Physicians of London, 2004.
10 Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol 2004;3: 50-8. 11. Ozduman K, Pober BR, Barnes P, et al. Fetal stroke. Pediatr Neurol 2004;30:151–62.
12. Golomb MR, MacGregor DL, Domi T, et al. Presumed pre- or perinatal arterial ischemic stroke: risk factors and outcomes. Ann Neurol 2001;50.163–8.
13. Carvalho KS, Bodensteiner JB, Conolly PJ, Garg PB. Cerebral venous thrombosis in children. J Child Neurol 2001;16.574–80.
14. deVeber GA, MacGregor D, Curtis b, Mayank S. Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 2000;15: 16–24.