Halit BAYKAN, Samet Vasfi KUVAT, Mehmet BOZKURT, Emin KAPI, Feyzi ÇELİK

Tissue necrosis following intramuscular diclofenac injection

İntramüsküler ilaç enjeksiyonları sonrasında ağrı, deride renk değisikliği ve deri nekrozu ile karakterizedir. Nadiren görülen bu sendrom, livedoid dermatitis veya embolia kutis medikamentosa (Nicolau Sendromu) adıyla anılır. Bu yazıda renal kolik ağrısı sebebi ile tek doz 75 mg. intramüsküler diklofenak sodyum enjeksiyonu yapılmıs 32 yasındaki erkek olguda gözlenen Nicolau Sendromu sunuldu. Olgunun fi zik incelemesinde sol gluteal bölge derisinde renk değisikliği ve nekroz mevcuttu. Olgu, nadir görülmesi nedeniyle oldukça ilgi çekicidir.

Kas içi diklofenak enjeksiyonunu takiben gelisen doku nekrozu

Following intramuscular drug injections, livedoid dermatitis (also known as embolia cutis medicamentosa or Nicolau Syndrome), characterized by pain, skin discoloration, and cutaneous necrosis, may rarely be observed. In the present study, we present a 32-year-old male patient who developed Nicolau Syndrome after intramuscular injec- tion of single-dose diclofenac sodium 75 mg due to renal colic pain. The physical examination revealed skin discoloration in his left gluteal region, and a skin necrosis. Case is very interesting because of rarely.

PDF

___

1. Uday PK. Nicolau syndrome. In: Valia RG, ed. What is new in Dermatology, Sexually Transmitted Diseases and Leprosy. Bombay: 2000:22-30.
2. Muller-Vahl H, Adverse reaction after intramuscular injections. Lancet 1983;1:1050.
3. Lie C, Leung F, Chow SP. Nicolau syndrome following intramuscular diclofenac administration: a case report. J Orthop Surg 2006;14:104-7.
4. Hamilton B, Fowler P, Galloway H, Popovic N. Nicolau syndrome in an athlete following intra-muscular diclofenac injection. Acta Orthop Belg 2008;74:860-4.
5. De Sousa R, Dang A, Rataboli PV. Nicolau syndrome following intramuscular benzathine penicilin. J Postgrad Med 2008;54:332-4.
6. Brethnach SM. Drug reactions, In: Champion RH, Burton JL, Burns DA, Brethnach S, eds. Textbook of Dermatology, 6th edn. London: Blackwell Science Ltd, 1998;3497.