Mehmet İbrahim TURAN, Atilla CAYİR, İbrahim Selcuk ESİN, Huseyin TAN

Çocukluk çağı epilepsisinde karbamazepin\'in tiroid fonksiyonları üzerine etkisi

Amaç: Çocuklarda karbamazepin tedavisinin tiroid fonsiyon testleri üzerine etkisini araştırmak Yöntem: Karbamazepin grubu epilepsi tanısıyla takip edilen elli sekiz çocuktan, kontrol grubu elli dört sağlıklı çocuktan oluşturuldu. Başlangıç yaşı, ilaç kullanım süresi, ilaç dozajı, ve serbest triiyodotironin (FT3), serbest tiroksin (FT4), tirotropin (TSH) parametrelerini içeren laboratuar parametreleri kaydedildi. Bu veriler kontrol grubuyla karşılaştırıldı. Bulgular: Karbamazepin grubunda sırasıyla, FT3 3,86 ± 0,43 pg/mL, FT4 1,15 ± 0,18 mg/dL TSH 2,58 ± 1,33 ml U/L olarak bulundu. Kontrol grubunda ise FT3 4,13 ± 0,59 pg/mL, FT4 1,34 ± 0,13 mg/dL ve TSH 2,06 ± 0,89 ml U/L olarak ölçüldü. İki grup arasında subklinik hipotiroidizm oranı istatistiksel olarak anlamlı değildi (p=0,196). Sonuç: Karbamazepin tiroid hormon konsantrasyonlarını düşürmesine rağmen nadiren hipotiroidizme neden olur.

Anahtar Kelimeler:

Çocuk, karbamazepin, tiroid fonksiyon testleri

The effects of carbamazepine on thyroid functions in childhood epilepsy

Objective: To investigate the effects of carbamazepine therapy on thyroid function tests in children Methods: The carbamazepine group consisted of 58 children under observation for epilepsy, and the control group of 54 healthy children. Age of onset, length of drug use, drug dosage and laboratory parameters including free triiodothyronine (FT3), free thyroxin (FT4) and thyrotropin (TSH) were recorded. These data were then compared against those from the control group. Results: In the carbamazepine group, FT3 was 3.86 ± 0.43 pg/mL, FT4 was 1.15 ± 0.18 mg/dL and TSH: 2.58 ± 1.33 ml U/L. In the control group, FT3 was 4.13 ± 0.59 pg/mL, FT4 1.34 ± 0.13 mg/dL and TSH was 2.06 ± 0.89 ml U/L. No statistically significant difference between rates of subclinical hypothyroidism was determined between the two groups (p=0.196). Conclusion: Although, carbamazepine reduces thyroid hormone concentrations, rarely causes hypothyroidism.

Keywords:

Child, carbamazepine, thyroid function tests,

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