Selma DERTLİOĞLU BAKAR, BETÜL DEMİR, Aziz KARAOĞLU, Haydar UÇAK

İnternal maligniteli hastalarda deri değişiklikleri

Giriş: İnternal maligniteler immünolojik, metabolik ve metastatik yollarla malign hücrelerin deriye metastazı, paraneoplastik sendromlar veya nonspesifik lezyonlar şeklinde çok sayıda deri bulgularına yol açabilirler. Amaç: Bu çalışmanın amacı internal maligniteli hastalarda deri bulgularını araştırmak ve bu hastalara yaklaşımda öncelikli deri sorunlarını irdelemektir. Yöntemler: Bu çalışmada karsinom tanısı almış, Fırat Üniversitesi Hastanesi Onkoloji servisinde yatarak tedavi gören iki yüz hastanın deri bulguları değerlendirildi. Hastaların anamnezleri kaydedildi, detaylı kutanöz ve sistemik muayene yapıldı, klinik fotografları çekildi. Gerekli görülen hastalarda deri biyopsisi, fungal enfeksiyonlar için kazıntı alındı ve tüm kutanöz metastatik lezyonlar histopatolojik olarak doğrulandı. Bulgular: Onkoloji servisinde yatmakta olan internal maligniteli 200 hastanın 88i (%44) kadın ve 112si (%56) erkekti. Hastalarda tanı konulan en sık primer tümörler 35 (%17,5) mide, 33 (%16,5) akciğer ve 31 (%15,5) kolorektal karsinomdu. Hastaların 83ünde (%41,5) saç bulguları mevcut olup saç tutulumunun kemoterapi (p=0,001), kür sayısı (p=0,001) ve radyoterapi (p=0,04) ile istatistiksel olarak anlamlı düzeyde ilişkili olduğu saptandı. Hastaların 119ünde (%59,5) tırnak bulguları mevcut olup, tırnak tutulumu kemoterapi (p=0,001) ve kür sayısı (p=0,05) ile ilişkili bulundu. Hastaların 100ünde (%50) oral mukoza tutulumu ve 132ünde (%66) palmoplantar tutulumu mevcut olup, her iki tutulum da alınan kemoterapi ile anlamlı düzeyde ilişkiliydi (p

Cutaneous changes in patients with internal malignancies

Objective: The aim of this study is to investigate skin findings in patients with internal malignancy and highlight the primary skin problems in these cases. Methods: In this study, the findings of cutaneous of 200 patients, hospitalized in the Department of Oncology Fırat University Hospital, were evaluated. The medical histories provided by the patients were recorded, comprehensive cutaneous and systemic examinations were performed, and clinical photos were taken. When considered necessary, skin biopsy and scrapings for fungal infections were collected, while all the cutaneous metastatic lesions were confirmed by histopathology. Results: Among the 200 inpatients with internal malignancy who were admitted to the Department of Oncology, 88 (44%) were female and 112 (56%) were male. Eighty-three patients (41.5%) had hair findings, while hair involvement was found to have a significant relationship with chemotherapy (p=0.001), number of cycles (p=0.001), and radiotherapy (p=0.04). As 119 patients (59.5%) exhibited nail findings, nail involvement was found to be linked with chemotherapy (p=0.001) and number of cycles (p=0.05). Oral mucosa involvement was observed in 100 patients (50%) and palmoplantar involvement was determined in 132 patients (66%); both were significantly associated with chemotherapy (p<0.05). Conclusion: As well as skin metastases, internal malignancy cases accompany with many hair, nail, skin, and mucosal findings, which are significantly associated with chemotherapy and the number of its cycles.

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