Monica GUPTA, Abha CHANDNA, Sanjay KUMAR, Sant Prakash KATARİA, Sonia HASİJA, Gajender SINGH, Rajeev SEN

Clinicohematological Profile of Pancytopenia: A Study from a Tertiary Care Hospital

Amaç: Pansitopeni geniş bir ayırıcı tanı yelpazesi olan klinik ve hematolojik bir problemdir. Hastaların detaylı bir incelemesi gerekmektedir çünkü etiyolojide geri dönü- şümlü bir etiyoloji olabileceği gibi erken patolojinin hayat kurtaracağı ciddi bir patolojide sorumlu olabilir. Pansito- peni tanısında kemik iliğinin hücresel ve morfolojik ince- lenmesi için kemik iliği aspirasyonu gerekmektedir. Bu çalışma, kemik iliği bulguları temelinde pansitopeninin nedenini bulmak amacıyla yapılmıştır. Yöntemler: Bu çalışma bir yıl süre içinde patoloji bölü- münde gerçekleştirilmiştir. Pansitopeni kriterlerini karşı- layan 169 hasta çalışmaya dahil edildi. Tüm olgularda, tam kan sayımı, periferik yayma incelemesi ve kemik iliği aspirasyonu takiben ayrıntılı klinik öykü ve fizik muayene yapıldı. Bulgular: Erkek kadın oranında erkek lehine hafif bir bas- kınlık vardı: 1/1.2. Hastaların büyük bir çoğunluğu, 10 lu ve 20 li yaşlarındaydılar. Pansitopenin ana nedeni mega- loblastik anemi ve ardından beslenme yetersizliği anemisi ve diğer nedenler olarak görüldü. Sonuç: Bu çalışma göstermiştir ki Hindistan gibi geliş- mekte olan ülkelerde pansitopeni etiyolojisi çoğunlukla geri dönüşümlü nedenlere bağlıdır ve bu ülkelerde hasta- lara kan yapıcı vererek yakın hematolojik takipleri önem- lidir.

Pansitopeninin Klinik ve Hematolojik Profili: Bir Üçüncü Basamak Hastane Çalışması

Objective: Pancytopenia is a clinicohematological prob- lem with wide spread discriminated diagnosis. A through evaluation of patient is necessary to identify the cause as large number of patients has reversible etiology and early diagnosis may be lifesaving. Diagnosis of pancyto- penia requires microscopic examination of bone marrow aspirates to assess the overall cellularity and morphol- ogy. This study was conducted with the aim to find out the cause of pancytopenia on the basis of bone marrow findings. Methods: The present study was conducted in the de- partment of pathology over a period of one year. A total of 169 patients were included in the study that fulfilled the criteria of pancytopenia. A detailed clinical history and physical examination followed by complete blood count, peripheral smear examination and bone marrow aspira- tion was done in all cases. Results: There was slight male predominance with male to female ratio of 1.2:1. The majority of patients were in second and third decade. The main cause of pancytope- nia was megaloblastic anemia followed by mixed nutri- tional deficiency anemia and others. Conclusion: This study emphasized that in developing countries like India majority of the patients had reversible etiology and patients can be put on a trial of hematinics and close haematological follow up.

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