Akciğer hamartomu: 24 olgunun retrospektif analizi

Amaç: Akciğer hamartomu akciğerin bening tümörleri içerisinde en sık karşılaşılan tümörüdür. Bu çalışmanın amacı kliniğimizde cerrahi tedavi uygulanan akciğer hamartomlu olguların klinik, radyolojik ve patolojik özelliklerini incelemektir. Yöntemler: Kliniğimizde Ocak 2005-Aralık 2017 tarihleri arasında cerrahi tedavi uygulanan akciğer hamartomlu 24 olgu retrospektif olarak incelendi. Çalışmamızda bu olgular; yaş, cinsiyet, klinik, histopatolojik ve radyolojik özellikleri, uygulanan cerrahi işlemler açısından değerlendirildi. Bulgular: Akciğer hamartomu nedeni ile cerrahi rezeksiyon uygulanan 24 olgunun, 14 tanesi erkek, 10 tanesi kadın ve yaş ortalaması 50.6 (23-66) yıl idi. Erkek/kadın oranı 1.4 olarak tespit edildi. 24 olgunun 17’si (%42) asemptomatik iken diğer hastalarda öksürük, nefes darlığı, göğüs ağrısı ve tekrarlayan akciğer enfeksiyonları mevcuttu. Hastaların 16’sında (%67) tümör sağ akciğer yerleşimliydi. Lezyonların 17’si (%71) periferik, 7’si (%29) santral lokalizasyonluydu. Bütün olgulara wedge rezeksiyonu yapıldı. İşlem 17 olguya torakoskopik olarak yapılırken, 7 olguya torakotomi ile gerçekleştirildi. Makroskopik incelemede ortalama tümör çapı 2.9 cm (1-4.5) olarak tespit edildi. Sonuç: Pulmoner hamartomlar sıklıkla periferik soliter pulmoner nodüller olarak ortaya çıkarlar. Kesin tanı ve tedavisinde düşük mortalite ve morbidite oranları olan cerrahi rezeksiyon önerilmektedir. Cerrahide amaç akciğer parankimini koruyarak lezyonun total eksize edilmesidir.

Pulmonary hamartoma: Retrospective analysis of 24 cases

Objective: Lung hamartoma is the most frequently diagnosed benign lung tumor. The aim of this study was toinvestigate the clinical, radiological and pathological data of the patients with pulmonary hamartoma who underwentsurgical treatment in our clinic.Methods: Hospital records of 24 lung hamartoma patients given surgical treatment in our clinics between January2005 and December 2017 were investigated retrospectively. In this study, these cases were evaluated with respect toage, gender, clinical, histopathological, and radiological features, and surgical methods.Results: There were 24 patients with a mean age of 50.6 (23-66) years, consisting of 14 males and 10 females, whounderwent surgical resection for pulmonary hamartoma was. While 17 (42%) patients were asymptomatic, the restcomplained of coughing, shortness of breath and repetitive lung infections. Hamartoma was localized in the right lungin 16 (67%) of the cases; peripherally in 17 (71%), and centrally in 7 (29%). All patients underwent wedge resection,17 cases by thoracoscopy and 7 cases by thoracotomy. The mean tumor diameter assessed macroscopically was 2.9cm (1-4.5cm). Conclusion: Pulmonary hamartomas frequently present as peripheral solitary nodules. Given its low morbidity andmortality, surgical resection is recommended for definitive diagnosis and treatment, the objective of the interventionbeing total excision of the lesion while protecting the lung parenchyma.

___

  • Özlü T,Metintaş M,Kaya A. Solunum sistemi ve hastalıkları Temel başvuru kitabı.Cilt 2. (Respiratory system and its diseases – Reference book, Volume 2): Istanbul Medikal Yayıncılık 2010; 1511-12.
  • Okudela K, Umeda S, Otara M, et all. A case of pulmonary hamartoma with distinctive histopathological features: a discussion of its differential diagnosis and histogenesis. Pathol Int 2014; 64: 618-23.
  • Suut S, Al-Ani Z, Allen C, et all. Pictorial essay of radiological features of benign intrathoracic masses. Ann Thorac Med. 2015 Oct-Dec; 10: 231-42.
  • Ekinci GH, Hacıömeroğlu O, Ersev A, et all. The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas. Rev Port Pneumol. 2017 Sep - Oct; 23: 280-6.
  • An J, Long M, Jiang Y, Jin Y. Concomitant a giant pulmonary bulla on the left lower lobe and hamartoma successfully treated by video-assisted thoracoscopic pulmonary wedge resection. AME Case Rep. 2017 Sep 26; 1: 2.
  • Abdel Hady SM, Elbastawisy SE, Hassaballa AS, Elsayed HH. Is surgical resection superior to bronchoscopic resection in patients with symptomatic endobronchial hamartoma? Interact Cardiovasc Thorac Surg. 2017 May 1; 24: 778-82.
  • Dimitrakakis G, Challoumas D, Rama Rao Podila S, et all. The challenge of pulmonary endobronchial chondromatous hamartomas.J BUON. 2014 Jan-Mar; 19: 60-5.
  • Elsayed H, Abdel Hady SM, Elbastawisy SE. Is resection necessary in biopsy-proven asymptomatic pulmonary hamartomas? Interact Cardiovasc Thorac Surg. 2015 Dec; 21: 773-6.
  • Siegelman SS, Khouri NF, Scott WW, et all. Pulmonary hamartoma: CT findings. Radiology 1986; 160: 313-7.
  • Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg 1967; 53: 735-42.
  • Ledor K, Fish B, Chaise L, Ledor S. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr 1981; 5: 343-4.
  • 9-Zehani-Kassar A, Ayadi-Kaddour A, Marghli A, et all. Clinical characteristics of resected bronchial hamartoma. Study of seven cases.Rev Mal Respir. 2011 May; 28: 647-53. 2011 Apr 16.
  • Asad S, Aquino SL, Piyavisetpat N, Fischman AJ. Falsepositive FDG positron emission tomography uptake in nonmalignant chest abnormalities. AJR Am J Roentgenol 2004; 182: 983–9.
  • Christensen JA, Nathan MA, Mullan BP, et all. Characterization of the solitary pulmonary nodule: 18F-FDG PET versus nodule-enhancement CT. AJR Am J Roentgenol2006; 187: 1361–7.
  • De Cicco C, Bellomi M, Bartolomei M, et all. Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg 2008; 86: 1769–72.
  • Settas N, Faucz FR, Stratakis CA. Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome. Mol Cell Endocrinol. 2018 Jul 5; 469: 107- 11.
  • Boikos SA, Xekouki P, Fumagalli E, et all. Carney triad can be (rarely) associated with germline succinate dehydrogenase defects. Eur J Hum Genet 2016; 24: 569–73.
  • Garofola C, Gross GP. Hamartoma, Cowden Disease (Multiple Hamartoma Syndrome). Stat Pearls Treasure Island (FL): Stat Pearls Publishing; 2018 - 2018 Oct 27.
  • Leiter Herrán F, Restrepo CS, Alvarez Gómez DI, et all. Hamartomas from head to toe: an imaging overview. Br J Radiol. 2017 Mar; 90 (1071): 20160607.
  • von Ranke FM, Zanetti G, e Silva JL, et all. Tuberous sclerosis complex: state-of-the-art review with a focus on pulmonary involvement. Lung 2015; 193: 619–27.
  • Xia Y, Wang KP. Transbronchial needle aspiration: where are we now? J Thorac Dis. 2013 Oct; 5: 678-82.
  • Klein JS. Transthoracic needle aspiration biopsy for the cytologic diagnosis of subsolid lung nodules. Cancer Cytopathol. 2016 Jul; 124: 451-2.
  • Serkan Bayram, Çağatay Tezel, Serdar Evman, ve ark. Sol ana bronş tümörüne sağ torakotomi ile izole sleeve rezeksiyon. Dicle Tıp Dergisi/Dicle Medical Journal 2017; 44: 119–23.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
Sayıdaki Diğer Makaleler

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

SARA EROL, BANU AYDIN, Hasibe Gökçe ÇINAR, Tamer YOLDAŞ, AYŞEGÜL ZENCİROĞLU

Katarakt Cerrahisi ile Aynı Seansta Skleral Askılı Göz İçi Lens Yerleştirilmesi

Selahattin BALSAK, Zeynep GÜRSEL ÖZKURT

Survival outcomes in patients with undifferentiated endometrial carcinoma

Alpaslan KABAN, Samet TOPUZ

Görsel Uyaranlara İlişkin Manyetoensefalografi Sinyallerinin Genelleştirilmiş Regresyon Sinir Ağı ile Sınıflandırılması

ONURSAL ÇETİN, FEYZULLAH TEMURTAŞ

A Stuttering Case Getting Well During Bipolar Disorder Manic Episode

Betül UYAR EKMEN

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

Nurten SERİNGEÇ AKKEÇECİ, Büşra SEĞMEN, SADIK YURTTUTAN, CAN ACIPAYAM, Zübeyde DİNÇER, GÖZEN ÖKSÜZ

Prognostic Value of Lymph Node and Spleen Activity in [18F]FDG PET-CT in Lung Adenocarcinoma and Squamous Cell Carcinoma

Halil KOMEK, Nadiye AKDENİZ, Zuhat URAKÇI, CANAN CAN, Serdar ALTINDAĞ

Tip 1 Diyabetes Mellituslu Çocuklarda Tanı Anındaki Klinik ve Laboratuvar Bulgularının Değerlendirilmesi

Burhan ARAS, ALPER AKIN, Ruken YILDIRIM, Edip ÜNAL, YUSUF KENAN HASPOLAT

Akciğer hamartomu: 24 olgunun retrospektif analizi

Erkan AKAR, Miktat Arif HABERAL, Özlem ŞENGÖREN DİKİŞ

Methicillin-Resistant Staphylococcus Strains Isolated from Adult Intensive Care Units with E-test MIC Values of Different Antibiotic Research

Narin GÜNDOĞUŞ, Kadri GÜL, Tuba DAL, NEZAHAT AKPOLAT