Meriç Emre BOSTANCI, Mustafa ATABEY, Sinan SOYLU, Birkan BOZKURT, Atilla KURT, Şahende ALAGÖZ, Mehmet İlker ÖZEL

Thyroid cancer incidence in thyroidecto- mies carried out in Sivas

Amaç: Tiroid kanserleri endokrin organların en sık görülen malignitesidir. Bu çalışmanın amacıSivas ilinde yapılan tiroidektomilerde tiroid kanseri sıklığını ve kanser tiplerini araştırmaktır.Yöntem: Ocak 2008-Ocak 2014 yılları arasında Cumhuriyet Üniversitesi Tıp Fakültesi GenelCerrahi kliniğinde yapılan tiroidektomi operasyonlarına ait patoloji raporlarıretrospektif olarak arşivden tarandı. Altı yıl içerisinde opere edilen toplam 521 olguya aitpostoperatif histopatolojik bulgular değerlendirildi.Bulgular: Toplam 521 olgunun 122si (%23,41) erkek, 399u (%76,58) kadındı. En genç hasta 15en yaşlı hasta 84 yaşında olup yaş ortalaması 49,02±13,48 idi. Histopatolojik incelemede 272(%52,2) olguda nodüler hiperplazi, 32 (%6,1) olguda diffüz hiperplazi, 22(%4,2) olguda lenfositiktiroidit, 30 olguda(%5,8)nodüler hiperplazi ve lenfositik tiroidit birlikteliği, 151 (%29) olguda isetiroid tümörü saptandı. 151 tümör olgusunun 9u (%5.9) benign, 142si (%94,0) malign idi. Kansertipi olarak 133 (%25,5) olguda papiller karsinom, 3 (%0,6) olguda folliküler karsinom, 2 (%0,4)olguda medüller karsinom ve 3 (%0,6) olguda anaplastik karsinom,1 (%0,2) olguda metastazsaptandı.14 (%2,7) olguda malign potansiyeli bilinmeyen iyi diferensiye tümör saptandı.Sonuç: Sivas ilinde yapılan tiroidektomilerde tiroid kanseri sıklığı %27,3 olup, en sık papillertiroid karsinomu görülmektedir.

Sivas ta yapılan tiroidektomilerde tiroid kanseri sıklığı

Objective: Thyroid cancers are the most common malignancy of the endocrine organs. Thepurpose of this study is to research the thyroid cancer incidence in the thyroidectomies carried outin the province of Sivas and cancer types.Methods: The pathology reports regarding the thyroidectomy operations carried out in the GeneralSurgery Clinic of the School of Medicine, Cumhuriyet University between January 2008 andJanuary 2014 were retrospectively scanned from the archive. The postoperative histopathologicalfindings, belonging to totally 521 cases operated within six years, were evaluated.Results: 122 (23.41%) of the total 521 cases were men and 399 (76.58%) were women. Theyoungest patient was 15 and the oldest patient was 84 years old, and also mean age of the patientswas 49.02 ±13.48. The followings were detected in the histopathological examination; nodularhyperplasia in 272 (52.2%) cases, diffuse hyperplasia in 32 (6.1%) cases, lymphocytic thyroiditisin 22 (4.2%) cases, association of nodular hyperplasia and lymphocytic thyroiditis in 30 (5.8%)cases and also thyroid neoplasm in 151 (29%) cases. 9 (5.9%) of 151 neoplasm cases were benignand 142 (94.0%) were malign. As the cancer type, the followings were detected; papillarycarcinoma in 133 (25.5%) cases, follicular carcinoma in 3 (0.6%) cases, medullary carcinoma in 2(0.4%) cases and anaplastic carcinoma in 3 (0.6%) cases, metastases in 1 (0.2%) case. The welldifferentiated tumour of uncertain malignant potential was detected in 14 (2.7%) cases.Conclusion: The cancer incidence in thyroidectomies carried out in the province of Sivas wasrecorded as 27.3% and the papillary thyroid carcinoma was the most common carcinoma.

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1. Schneider AB, Ron E. Carcinoma of follicular epithelium. In: Braverman LE, Utiger RD. Werner and Ingbar's the Thyroid. 8th ed. Philadelphia: Lippincott Williams and Wilkins 2000; 878-86.
2. Hundahl SA, Cady B, Cunningham MP, Mazzaferri EL, Mc Kee RF, Rosai J. Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in United States during 1996 (An American College of Surgeons Commission on Cancer Patient Care Evaluation Study). Cancer 2000; 89: 202-17.
3. Jameson JL, Weetman AP. Thyroid cancer. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrisons Principles of İnternal Medicine. 15th ed 2001: 2079-83.
4. Rosai J. Rosai and Ackermans Surgical Pathology. 9th ed. Vol I, Mosby 2004; 532-42.
5. DeLellis RA, Lloyd RV, Heitz PU, Eng C. Pathology and Genetics of Tumours of Endocrine Organs. Lyon, IARC Pres 2004; 50-66.
6. Bozkurt K, Bektaş SS. Şırnak ilinde ameliyat edilen nodülern guatr olgularında tiroid kanseri görülme sıklığı. Dicle Tıp Derg 2010; 37: 363-6.
7. Robbins J, Merino MJ, Boice JD. Thyroid cancer: A lethal endocrine neoplasm. Ann Intern Med 1991; 115: 133-47.
8. Canda MŞ, Ulukuş Ç, Harmancıoğlu Ö. İzmir bölgesinde tiroid kanserleri (159 olgu). Türkiye Ekopatoloji Dergisi 1999; 5: 13-6.
9. Canda MŞ, Canda T, Gökden N. Tiroid karsinomlarının patolojisi (olgu). Türk Patoloji Dergisi 1995; 11: 99-102.
10. Özgüven BY, Yener Ş, Başak T. Tiroid operasyon materyali histopatolojik tanılarının retrospektif olarak değerlendirilmesi. ŞEH Tıp Bülteni 2008; 42: 5-9.
11. Şarlar H, İlhan E, Üstüner MA. Nodüler guatr tanısı ile ameliyat edilen vakalarda malignite sıklığı. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 2013; 17: 15-24.
12. Çelik AŞ, Güzey D, Çelebi F. Dominant nodül çapına göre tedavi edilen benign nodüler tiroid has- talıklarında insidental tiroid karsinom sıklığı. Bakırköy Tıp Dergisi 2011; 7: 6-10.
13. Ezzat S, Sarti DA, Cain DR, Braunstein GD. Thyroid inciden- telomas prevalence by palpation and ultrasonography. Arch Intern Med 1994; 154: 1838-40.
14. Knudsen N, Perrild H, Christiansen E. Thyroid structure and size and two-year follow-up of solitary cold thyroid nodules in an unselected population with borderline iodine deficiency. Eur J Endocrinol 2000; 142: 224-30.
15. Serra S, Asa SL. Controversies in thyroid pathology: The diagnosis of follicular neoplasms. Endocr Pathol 2008; 19: 156-65.
16. Pakiş I, Karyel F, Sav AM. Adli otopsilerde tiroid patolojileri (180 olgu). Türkiye Ekopatoloji Dergisi 2004; 10: 109-13.
17. Arslan K, Eryılmaz MA, Eroğlu C, Karahan Ö. Total tiroidektomi uygulanan benign tiroid hastalıklı olgularda rastlantısal tiroid kanseri riski. Genel Tıp Derg 2010; 20: 19-22.
18. Yamashita H, Noguchi S. Watanabe S. Thyroid cancer asso- ciated with adenomatous goiter: An analysis of the incidence and clinical factors. SurgToday 1997; 27: 495-9.
19. Mills SE. Sternbergs Diagnostic Surgical Pathology. 4th ed. Vol I, Philadelphia, Lippincott Williams and Wilkins 2004; 564-72.
20. Simoes MS, Saavedra JA, Tallini G. Poorly Differentiated Carcinoma. De lellis R, Lloyd RV, Heitz PU, Eng C. World Health Organization Classification of Tumors Pathology and Genetics: Tumours of Endocrin Organs. IARC pres Lyon 2004: 73-6.
21. Ordonez N, Baloch Z, Matias-Gulu X. Undifferentiated (anaplastic) Carcinoma. De lellis R, Lloyd RV, Heitz PU, Eng C. World Health Organization Classification of Tumors Pathology and Genetics: Tumours of Endocrin Organs. IARC pres Lyon 2004: 77-80.
22. Güneş P, Aker FV, Erkan M. Incidental anaplastic thyroid carcinoma: A case report. Turkish Journal of Pathology 2008; 24: 54-8.