The near future of head louse control

Saç biti enfestasyonu tüm dünyada yaygın bir halk sağlığı sorunudur. Yüksek gelirli ülkelerdepedikülozis kapitis temel olarak okul çağındaki çocuklarda problemdir. Son 20 yılda özelliklenörotoksik yolla etkili pedikülositlere direnç gelişimi ve toksikolojik endişeler nedeniyle,dimetikon gibi fiziksel olarak etkili yeni ürünlere eğilim görülmeye başlanmıştır. Bu maddelerintrakeal sisteme girerek bitleri ve yumurtalarını boğduğu gösterilmiştir. Bu niteliğine bağlı olarakbitlerin en azından kolaylıkla direnç geliştiremeyeceği beklenmektedir. Dimetikon kozmetikaçıdan kabul edilebilir, fizyolojik olarak etkisiz ve toksik olmayan bir üründür. Bu nedenle yakıngelecekte bitlerin tedavisinde seçenek olması beklenmektedir.

Saç biti kontrolünün yakın geleceği

Infestation with head lice is a worldwide public health concern. In high income countriespediculosis capitis is a problem mainly in school-aged children. In the last two decades and mainlyas a result of resistance to pediculicides with a neurotoxic mode of action and due to thetoxicological concerns, a new trend to products acting by physical means such as dimethicone, hasbeen observed. It was shown that these substances are capable of entering the tracheal system andasphyxiating the lice and their eggs. Due to this quality it could be expected that lice, if at all,could not easily develop resistance. Dimethicone is a cosmetically acceptable product,physiologically inert and non-toxic and therefore it is expected to become the treatment-of-choicefor lice in the near future.

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  • 1. Mumcuoglu KY, Barker SC, Bur- gess IF. International guidelines for effective control of head louse infestations. J. Drugs Dermatol 2007; 6: 409-14.
  • 2. Mumcuoglu KY. Control of head louse (Anoplura: Pediculidae) in- festations: Past and present. Amer. Entomol 1996; 42: 175-8.
  • 3. Mumcuoglu KY. Effective treat- ment of head louse with pedicu- licides. J. Drugs Dermatol 2006; 5: 451-2.
  • 4. Hemingway J, Miller J, Mum- cuoglu KY. Pyrethroid resistance mechanisms in the head louse Pe- diculus humanus capitis from Isra- el: Implications for control. Med. Vet. Entomol 1999; 13: 89-96.
  • 5. Burgess IF. The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis. BMC Pharmacology 2009; 9: 3.
  • 6. Burgess IF, Brown CM, Lee PN. Treatment of head louse infesta- tion with 4% dimeticone lotion: Randomised controlled equiva- lence trial. BMJ 2005; 330; 1423.
  • 7. Burgess IF, Lee PN, Matlock G. Randomised, controlled, assessor blind trial comparing 4% dimeti- cone lotion with 0.5% malathion liquid for head louse infestation. PLoS 2007; 2: 1127.
  • 8. Burgess IF, Brunton ER, Burgess NA. Single application of 4% di- meticone liquid gel versus two ap- plications of 1% permethrin crème rinse for treatment of head louse infestation: A randomised con- trolled trial. BMC Dermatology 2013; 13: 5.
  • 9. Heukelbach J, Pilger D, Oliveira FA, Khakban A. Ariza L, Feld- meier H. Efficacious pediculicide based on dimeticone: Randomized observer blinded comparative trial. BMC Infectious Diseases 2008; 8: 115.
  • 10. Heukelbach J. Asenov A, Liesen- feld O, Mirmohammadsadegh A, Oliveira FA. A new two phase di- meticone pediculicide shows high efficacy in a comparative bioassay. BMC Dermatology 2009; 9: 12.
  • 11. Richling I, Böckeler W. Lethal ef- fects of treatment with a special dimeticone formula on head lice and house crickets Insights into physical mechanisms. Arzneimit- telforschung 2008; 58: 248-254.
  • 12. Kurt O, Balcioğlu IC, Burgess IF, Limoncu ME, Girginkardeşler N, Tabak T, Muslu H, Ermiş O, Sahin MT, Bilac C, Kavur H, Ozbel Y. Treatment of head lice with dimet- icone 4% lotion: Comparison of two formulations in a randomised controlled trial in rural Turkey. BMC Public Health 2009; 9: 441.
Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi