İclal KOL ÖZDEMİR, Kenan KAYGUSUZ, Ahmet Cemil İSBİR, Onur AVCI, Sinan GÜRSOY, Cevdet DÜĞER, Mehmet Caner MİMAROĞLU

The effects of sedative agents used in intensive care unit on QT interval

Amaç: Bu çalışmanın amacı, yoğun bakım ünitelerinde (YBÜ) kullanılan sedatif ajanların QT intervali üzerine olan etkilerini araştırmaktır. Yöntem: Çalışmaya solunum yetmezliği nedeniyle yoğun bakım ünitesine alınmış, mekanik ventilatöre bağlı 90 hasta dahil edildi. Solunum yetmezliği nedeniyle yoğun bakım ünitesine alınan hastalar solunumsal ve kardiyak monitorizasyonları sağlandıktan sonra 12 derivasyon EKG'leri çekilerek, eşzamanlı olarak sistolik kan basıncı(SKB), diyastolik kan basıncı(DKB), ortalama kan basıncı(OKB), kalp atım hızı (KAH), ve periferik oksijen satürasyonu (SpO2) değerleri kaydedildi. Bu değerler baz olarak alındı. Hastalara sedasyon (midazolam, propofol veya deksmedetomidin) başlandıktan 1 ve 12 saat sonra tekrar 12 derivasyon EKG'leri çekildi ve yine eş zamanlı olarak SKB, DKB, OKB, KAH ve SpO2 değerleri kaydedildi. EKG kayıtları 1 mV yüksekliğinde ve 25 mm/s hızında gerçekleştirildi. EKG kayıtlarındaki tüm derivasyonlar arasından en uzun QT mesafesi, grupları bilmeyen 2 anestezist tarafından ölçülerek ve aynı derivasyondaki RR mesafesi ölçülerek QTc (düzeltilmiş QT) mesafesi Bazzet formülüyle hesaplandı (QTc=QT intervali / ? RR intervali). Hesaplanan QT ve QTc değerleri kaydedildi. Bulgular: 12. saatteki KAH değerlendirildiği zaman, dexmedetomidin grubundaki KAH, midazolam ve propofol grubundaki KAH'a göre istatistiksel olarak anlamlı bir şekilde düşüktü (p

Yoğun bakım ünitesinde kullanılan sedatif ajanların QT intervaline etkisi

Objective: The aim of this research is the effects of sedative drugs which are used on intensive care unit (ICU) patients on QT interval. Method: 90 patients who were hospitalized at ICU due to respiratory insufficiency and connected to mechanic ventilator were included. After the respiratory and cardiac monitorizations were enabled on patient with respiratory insufficiency in ICU, 12 derivations ECG's were recorded, systolic blood pressure (SBP), diastolic blood pressure(DBP), mean arterial blood pressure(MABP), heart rate(HR) and peripheric oxygen saturation (SpO2) values were recorded simultaneously. These values were used as base. At 1st and 12th hours of sedation (midazolam, propofol or dexmedetomidin), 12 derivations ECG's were recorded and again, SBP, DBP, MBP, HR and SpO2 values were recorded. ECG's were recorded at the speed of 25mm/s and at the height of 1 mV. Among the derivations in ECG recordings, the longest QT interval was measured by 2 anesthesiologists who don't know the groups and by measuring the RR interval on the same derivation, QTc (corrected QT) interval was measured with Bazzet formula. (QTc=QT intervali / ? RR interval) .Measured QT and QTc values were recorded. Results: When HR's at 12th hour were evaluated, HR at dexmedetomidin group was lower than both midazolam and propofol groups' HR and this was statistically significant (p

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