Coban G, N UNVER, Z GUCIN, HS KIZILTAN, A ARMAGAN

Biphasic malignant mesothelioma of the testis: Case report

Malign Mezotelyoma, seröz yüzeylerden kaynaklanan bir tümördür. En sık plevrada görülmekte olup periton ve nadiren paratestiküler bölge de diğer yerleşim yerlerindendir. Olgumuz sağ skrotal bölgede ağrı ve şişlik şikayeti ile başvurmuştu. Tümör belirteçleri (Alfa Fetoprotein, Beta HCG, Alkalan Fosfataz vb.) normal sınırlardaydı. Ultrasonografide tunika vaginalis invazyonu gösteren nodüler kitleleri mevcuttu. Nodüllerin en büyüğü 5 cm çapındaydı. Tunika vaginalis invazyonu ve yaygın tümör olması nedeniyle orşiektomi yapıldı. Morfolojik ve immünohistokimyasal olarak mezotelyoma tanısı kondu. Ayrıca klasik epitelyal komponente %10 sarkomatöz alanın da eşlik etmesi ile Bifazik Mezotelyoma tanısı verildi. Ayırıcı tanıda mezotelyum kaynaklı diğer lezyonlar, rete testis ve epididimin adenokarsinomu, metastatik adenokarsinomlar ve seminom ve embriyonel karsinom gibi testisin germ hücreli tümörleri düşünülmelidir. Tümör belirteçleri normal, yaygın tümör nodülleri olan vakalarda mezotelyal orjinli tümörler de düşünülmelidir

Testisin bifazik malign mezotelyoması: Olgu sunumu

Malign Mesothelioma is a tumor originating from serous lining. Although it was most commonly seen in pleura, it can also located in other areas such as peritoneal and rarely paratesticular region. Our case presented with pain and swelling in the right scrotal region. Tumor markers were within normal limits (Alpha Fetoprotein (AFP), Beta Human Chorionic Gonadotropin (Beta-HCG) and alkaline phosphatas Ultrasonographic examination revealed that nodular masses which infiltrating tunica vaginalis. The largest diameter of the nodules was 5 cm. Radical orchiectomy was performed because of the tunica vaginalis invasion and tumor extensity. The patient was diagnosed as mesothelioma with morphological and immunohistochemical examination. Addition to classical epithelial component, accompanying sarcomatous component (%10) led us to give the biphasic mesothelioma diagnosis Mesothelium originated other lesions, adenocarcinoma of the rete testis, papillary serous neoplasm of testis and epididymis, metastatic adenocarcinomas and germ cell tumors of testis such as seminoma and embriyonal carcinoma should be considered in the differential diagnosis. The patients with widespread tumor nodules and having normal tumor markers mesothelial originated tumors should be taken into differantial diagnosis

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