ST-segment elevasyonlu miyokard infarktüsünde başvuru kan üre azotu ile hastane içi ve uzun dönem mortalite arasındaki ilişki
Amaç: Çalışmanın amacı kan üre azotu (KÜA) seviyesi ile ST-elevasyonlu miyokard infarktüsündeki (STEMİ) tüm nedenli mortalite arasındaki ilişkiyi araştırmaktı. Yöntem: Bu çalışma primer perkütan koroner girişim yapılan 3378 STEMİ hastalarını içermekteydi. Hastane içi mortalitede başvuru KÜA seviyesi eşik değeri ROC analizinde 17.5 mg/dL olarak ve sensivite %68, spesifite %66 olarak saptanmıştır (AUC: 0.75; 95% CI:0.72-0.88; p < 0.001). Bulgular: Hastalar ortalama olarak 33±0.14 ay izlenmiştir. Yüksek KÜA seviyesine sahip hastalarda düşük KÜA seviyesine sahip hastalara göre hastane içi mortalite 5.3 kat (OR: 6.0, 95% CI: 4.4-8.3), uzun dönem mortalite 5 kat (HR: 5.3, 95% CI: 4.2-6.8) yüksek olarak saptanmıştır. Sonuç: Bu çalışmada yüksek KÜA seviyesi bağımsız olarak hastane içi ve uzun dönem mortalite ile ilişkili olarak bulunmuştur. KÜA testi basit, ucuz ve kolaylıkla uygulanabilen bir yöntemdir. Bu yüzden, STEMİ geçiren yüksek riskli hastaları saptamada kullanılabilir.
The association between admission blood urea nitrogen levels with in-hospital and long-term mortality in ST-segment elevation myocardial infarction
Objective: The aim of this study was to investigate the association of blood urine nitrogen (BUN) levels with all-causemortality in ST-segment elevation myocardial infarction (STEMI).Method: This study included 3778 patients with STEMI treated with primary percutaneous coronary intervention. Anadmission BUN of 17.5 mg/dL was identified through a ROC analysis as an optimal cutoff value to predict the inhospitalmortality with 68% sensitivity and 66% specificity (AUC: 0.75; 95% CI:0.72-0.88; p < 0.001).Results: The patients were followed up for a mean period of 33±0.14 months. Patients with higher BUN levels had 5.3-times higher in-hospital (OR: 6.0, 95% CI: 4.4-8.3) and 5-times higher long-term (HR: 5.3, 95% CI: 4.2-6.8) mortalityrates than patients with lower BUN levels.Conclusions: This study demonstrated that elevated BUN level was independently associated with increased in-hospitaland long-term mortality. BUN test is a simple, inexpensive, and easily bedside applicable method. Hence, it can be usedto detect high-risk patients in the setting of STEMI.Keywords: Blood urine nitrogen; ST-segment elevation myocardial infarction; primary percutaneous coronaryintervention; mortality
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