Tarana GUPTA, Deepak JAIN, Hari Krishan AGGARWAL, Promil JAIN, Vipin KAVERAPPA, Ashwani KUMAR

Benign recurrent intrahepatic cholestasis associated with pregnancy

Benign rekürren inrahepatik kolestaz nadir bir durum olup 18q21 kromozomu üzerindekiaminofosfolipid flippaz geni ATP8B1de oluşan mutasyona ikincil gelişen otozomal resesif birhastalık olduğu düşünülmektedir. Gamma glutamil transferaz enziminin normal olduğu rekürrenintrahepatik kolestaz epizotları ile karakterizedir.Burada gebelikle ilişkili bir benign intrahepatikkolestaz olgusu anlatılmıştır.

Gebelikle ilişkili benign rekürren intrahep atik kolestaz

Benign recurrent intrahepatic cholestasis is a rare condition which is believed to be an autosomalrecessive disorder characterized by mutation in the aminophospholipid flippase gene ATP8B1located on chromosome 18q21. It is characterized by recurrent episodes of intrahepatic cholestasiswith normal gamma glutamyl transferase. We here describe a case of benign intrahepaticcholestasis associated with pregnancy.

PDF

___

1. Summerskill WH, Walshe JM. Benign recurrent intrahepatic "obstructive" jaundice. Lancet 1959; 2: 686-90.
2. Aggarwal HK, Gupta A, Lamba A. Benign recurrent intrahepatic cholestasis. JIACM 2008; 9: 306-7.
3. Everson GT. Preexisting and pregnancy indused liver disorders (online) 1998. Article available form URL: www.medscape.com/viewarticle/722320_2 (Accesed on December 06, 2012).
4. Sasaki KJ, Peterson E. Pregnancy and Liver disorder (online).2009 (cited 2009 Aug19); Available from URL:http://emedicine.medscape.com/a/188143 (Accesed on December 06, 2012).
5. Gupta V, Kumar M, Bhatia BD. Benign recurrent intrahepatic cholestasis. Indian J Pediatr 2005; 72: 793-4.
6. van Ooteghem NA, Klomp LW, van Berge-Henegouwen GP, Houwen RH. Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: low GGT cholestasis is a clinical continuum. J Hepatol 2002; 36: 439-43.
7. den Dulk M, Valentijn RM, Welten CA, Beyer GP.Intrahepatic cholestasis of pregnancy. The Neth J Med 2002; 60: 366-9.
8. Muresan D, Ona D, Cruciat G, Rotar I, Stamatian F. Recurrent Intrahepatic Cholestasis of Pregnancy. A Case Report. J Gastrointestin Liver Dis 2008; 17: 323-5.