Teena BANSAL, Savita SAİNİ, Punit MAHTA, Susheela TAXAK

A study to compare dexamethasone and ondansetron for preventing postopera- tive nausea and vomiting in children un- dergoing tonsillectomy

Amaç: Postoperatif bulantı ve kusmanın tedavisi için antiemetic olarak çeşitli ilaçlarkullanılmaktadır. Bu çalışmada tonsillektomi yapılan çocuklarda postoperative bulantı ve kusmayıönlemek için ondansetron ve deksametazonun etkinliği değerlendirilmektedir .Yöntem: Genel anestezi altında tonsillektomi yapılan 4-12 yaşları arasında Grade I ve Grade IIASA fiziksel durumuna sahip 60 çocuk çalışmaya dahil edildi. Bunlar her biri 20şer kişidenoluşan üç gruba ayrıldı. İndüksiyondan sonra sırasıyla Grup I, Grup II ve Grup IIIdeki hastalaranormal salin ya da deksametazon 500 µg/kg ya da 150 µg/kgdan oluşan test solüsyonu A (2 mL)verildi. Cerrahinin sonunda, anestezikleri switch yapmadan önce test solüsyonu B (2 mL) At theend of surgery before switching off anaesthetics, ondansetron 0.15 mg/kg (maksimum 4 mg) ya danormal salin ya da ondansetron 0.1 mg/kg (maksimum 2 mg)dan oluşan test solüsyonu B (2 mL)verildi. Postoperatif bulantı ve kusma sayısı, antiemetic ve analjezik uygulama sıklığı kaydedildi.Bulgular: Grup IIde hastaların %80inde, Grup Ideki %70 ve Grup IIIdeki %50 ilekarşılaştırıldığında bulantıya sahipti. Grup II ve III arasındaki fark istatistiksel olarak anlamlı idi(p

Tonsillektomi yapılan çocuklarda postoperative bulantı ve kusmayı önlemek için deksametazon ve ondansetronun karşılaştırmalı bir çalışması

Objective: Various drugs have been used as antiemetics for treatment of postoperative nausea andvomiting. The present study was undertaken to assess the efficacy of ondansetron anddexamethasone for preventing postoperative nausea and vomiting in children undergoingtonsillectomies.Method: Sixty children having ASA physical status Grade I or II in the age group 4-12 yearsundergoing tonsillectomy under general anaesthesia were included in the study. These wereallocated to three groups of twenty patient each. After induction patients were given test solutionA (2 mL) comprising of normal saline or dexamethasone 500 µg/kg or 150 µg/kg in Group I, IIand III respectively. At the end of surgery before switching off anaesthetics, test solution B (2 mL)was given comprising of ondansetron 0.15 mg/kg (maximum upto 4 mg) or normal saline orondansetron 0.1 mg/kg (maximum upto 2 mg). Postoperatively incidence of nausea, number ofvomiting episodes, frequency of administration of rescue antiemetic and analgesic were recorded.Results: In Group II 80% of patients had nausea as compared to 70% in Group I and 50% in groupIII and the difference between Group II and III was statistically significant (p

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