Çapraz Bağlı Maleik Anhidrit-Stiren-MetilMetakrilat Terpolimerine Dayalı pH-Duyarlı HidrojellerinHazırlanması ve Karakterizasyonu
Bu çalışmada; hidrojeller, maleikanhidrit-stiren-metilmetakrilat terpolimerinin N, N'metilenbisakrilamid ve glutaraldehitin farklı oranları ile çapraz bağlanmasıyla sentezlenmiştir. Çapraz bağlanma reaksiyonları çözücü olarak tetrahidrofuran varlığında farklı zaman periyodunda 25-50ºC aralığında gerçekleştirilmiş ve malzeme özellikleri kıyaslanmıştır. Her bir çapraz bağlayıcı tipi için çapraz bağlanma sıcaklığı, zamanı ve çapraz bağlayıcı oranı gibi etkin çapraz-bağlanma koşulları belirlenmiştir. Hidrojellerin şişme davranışı Tris tampon ortamlarda farklı pH aralığında 37ºC’de incelenmiştir. Hidrojellerin pH-duyarlı olduğu ve pH’ya bağlı şişmenin çapraz bağlayıcının fonksiyonel grubundan etkilendiği görülmüştür. Hidrojellerin moleküler yapısı Fourier Transform Infrared Spektroskopisi ile, gözenekyapısı da taramalı electron mikroskobu ile incelenmiştir.
Preparationand Characterization of pH-Sensitive Hydrogels Based on Crosslinked Maleic Anhydride-Styrene-Methyl Methacrylate Terpolymer
Inthis study, the hydrogels have been synthesized by the crosslinking reactions maleicanhydride-styrene-methyl methacrylate terpolymer with N, N'-methylene-bis-acrylamide and glutaraldehyde in variouscrosslinker ratios. Crosslinking reactions were carried out in the presence of tetrahydrofuranas solvent at 25-50ºC for different time period, and the resulting materialproperties compared. The best conditions for effective crosslinking, i.e., crosslinkingtemperature, time and crosslinker ratios were determined for each crosslinkertype. The swelling behaviour of the hydrogels was examined in Tris-buffersolutions at various pH at 37ºC. Swelling depending on pH was observed in thehydrogels. The pH-dependent swelling of hydrogels was strongly influenced bythe functional group of crosslinker. The molecular structure of the hydrogelswas studied by Fourier Transform Infrared Spectroscopy and their pore structurewas investigated by using Scanning Electron Microscope.
___
- Qiu Y., Park K., Environment-sensitive hydrogels for drug delivery, Adv. Drug Del. Rev.53 (2001) 321-339.
- İmren D., Gümüşderelioğlu M., Güner A., Synthesis and characterization of dextran hydrogels prepared with chlor- and nitrogen-containing crosslinkers, J. Appl. Polym. Sci. 102 (2006) 4213-4221.
- Dispenza C., Tripodo G., LoPresti C., Spadaro G., Giammona G., Synthesis, characterisation and properties of α, β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-maleic anhydride precursors and their stimuli-responsive hydrogels, React. Funct. Polym. 69 (2009) 565-575.
- Alzari V., Ruiu A., Nuvoli D., Sanna R., Martinez J.I., Appelhans D., Voit B., Zschoche S., Mariani A., Three component terpolymer and IPN hydrogels with response to stimuli, Polymer 55 (2014) 5305-5313.
- Singh B., Chauhan G.S., Kumar S., Chauhan N., Synthesis, characterization and swelling responses of pH sensitive psyllium and polyacryamide based hydrogels for the use in drug delivery (I), Carbohydr.Polym.67 (2007) 190-200.
- İmren D., Gümüşderelioğlu M., Güner A., In vitro release kinetics of bovine serum albumin from highly swellabledextran hydrogels, J. Appl. Polym. Sci.115 (2010) 740-747.
- Shalviri A., Chan H.K, Raval G., Abdekhodaie M.J., Liu Q., Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin, Colloids.Surf.B: Biointerfaces101 (2013) 405-413.
- Xu Q., Huang W., Jiang L., Lei Z., Li X., Deng H., KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release, Carbohydr. Polym. 97 (2013) 565-570.
- Koetting M.C.,Peppas N.A., pH-Responsivepoly(itaconicacid-co-N-vinylpyrrolidone) hydrogelswithreducedionicstrengthloadingsolutionsofferimproved oral deliverypotentialforhighisoelectricpoint-exhibitingtherapeuticproteins, Int. J.Pharm.471 (2014) 83–91.
- Akperov E.O.,Maharramov A.M., Akperov O.G., Uranyl ion adsorption using novel cross-linked maleic anhydride-allyl propionate-styrene terpolymer, Hydrometallurgy 100 (2009) 76-81.
- Dalaran M., Emik S., Güçlü G., İyim T.B., Özgümüş S., Removal of acidic dye from aqueous solutions using poly(DMAEMA-AMPS-HEMA) terpolymer/MMT nanocomposite hydrogels, Polym. Bull.63 (2009) 159-171.
- İmren D., Boztuğ A., Yılmaz E., Zengin H.B., Viscometric investigation of compatibilization of the poly(vinyl chloride)/poly(ethylene-co-vinyl acetate) blends by terpolymer of maleic anhydride-styrene-vinyl acetate, J. Mol.Struct. 891 (2008) 329-332.
- İmren D., Compatibilization of immiscible poly(vinyl chloride)(PVC)/polystyrene (PS) blends with maleic anhydride-styrene-vinyl acetate terpolymer (MAStVA), J. Mol.Struct.963 (2010) 245-249.
- Arimoto M., Ichikawa H., Fukumori Y., Microencapsulation of water-soluble macromolecules with acrylic terpolymers by the wurster coating process for colon-specific drug delivery, Powder Technol. 141 (2004) 177-186.
- Rimmer S., German M.J., Maughan J., Sun Y., Fullwood N., Ebdon J., MacNeil S., Synthesis and properties of amphiphilic networks 3: preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)), Biomaterials 26 (2005) 2219-2230.
- Wilson J.T., Cui W., Sun X.L., Burden C.T, Weber C.J, Chaikof E.L., In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film, Biomaterials 28 (2007) 609-617.
- Moshaverinia A., Roohpour N., Darr J.A., Rehman I.U., Synthesis and characterization of a novel N-vinylcaprolactam-containing acrylic acid terpolymer for applications in glass-ionomer dental cements, ActaBiomater. 5 (2009) 2101-2108.
- Cheng C., Ma L., Wu D., Ren J., Zhao W., Xue J., Sun S, Zhao C., Remarkable pH-sensitivity and anti-fouling property of terpolymer blended polyethersulfone hollow fiber membranes, J. Membr. Sci. 378 (2011) 369-381.
- Li H., Liao J., Xiang T., Wang R., Wang D., Sun S., Zhao C., Preparation and characterization of pH-and thermo-sensitive polyethersulfone hollow fiber membranes modified with p(NIPAAm-MAA-MMA) terpolymer, Desalination 309 (2013) 1-10.
- Bajpai S.K., Dubey S., Synthesis and swelling kinetics of a pH-sensitive terpolymeric hydrogel system, Iran.Polym. J. 13:3 (2004) 189-203.
- Gümüşderelioğlu M., Topal I.U, Vinyl ether/acrylic acid terpolymer hydrogels synthesized by -radiation: characterization, thermosensitivity and pH-sensitivity. Radiat. Phys. Chem. 73 (2005) 272-279.
- Paris R., Barrales-Rienda J.M, Quijada-Garrido I., Dynamic swelling of hydrogels based on random terpolymers of N-isopropylacrylamide, methacrylic acid and poly(ethylene glycol) macromonomer, Polymer 50 (2009) 2065-2074.
- Reinicke S., Schmelz J., Lapp A., Karg M., Hellweg T., Schmalz H., Smart hydrogels based on double responsive triblock terpolymers, Soft Matter 5 (2009) 2648-2657.
- Ngadaonye J.I., Cloonan M.O., Geever L.M., Higginbotham C.L., Synthesis and characterization of thermo-sensitive terpolymer hydrogels for drug delivery applications, J. Polym. Res. 18 (2011) 23072324.
- Micic M., Stamenic D., Suljovrujic E., Radiation-induced synthesis and swelling properties of p(2-hydroxyethyl methacrylate/itaconic acid/oligo(ethylene glycol) acrylate) terpolymeric hydrogels, Radiat. Phys. Chem. 81 (2012) 1451-1455.
- Yin C., Xu A., Gong L., Zhang L., Geng B., Zhang S., Preparation of slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene) functional microspheres with anhydride groups via precipitation polymerization, Particuology 19 (2015) 99-106.
- Boztuğ A., Basan S., Ekberov O.E., Characterization and synthesis of some alternating terpolymers of maleic anhydride, Mat. Res. Innovat., 8.2 (2004) 89-92.
-
Heath D.E., Cooper S.L., Design and characterization of sulfobetaine-containing terpolymer biomaterials, ActaBiomater. 8 (2012) 2899-2910.