Yaygın idiopatik nekrobiyozis lipoidika: olgu sunumu
Nekrobiyozis lipoidika, granülomatöz bir deri hastalığı olup etyolojisi ve patogenezi tam açıklanamamıştır. nekrobiyozis lipoidika ile diabetes mellitus birlikteliği sık sık tartışılmakta ve mikroanjiyopatinin önemli bir role sahip olduğu düşünülmektedir. Tedavi seçenekleri çok olmasına rağmen standart tedavi modeli yoktur. Bu çalışmada bacaklarında başlayıp vücuduna yayılan, yaygın cilt lezyonları olan ve punch biyopsi ile nekrobiyozis lipoidika tanısı konulan 43 yaşındaki bayan hasta sunuldu. Hastada nekrobiyozis lipoidika ile beraber eş zamanlı diyabetes mellitus olduğu saptandı. Tedavi sonrası diyabetes mellitus kliniği düzelen ama nekrobiyozis lipoidika tablosu tam olarak düzelmeyen hastaya; yapılan testlerinde otoimmün hepatit saptanılarak immünsupresif tedavi verildi ve hastanın tedavisi sağlandı. Olgumuz bazında nekrobiyozis lipoidika etyolojisi ve tedavisi literatür eşliğinde değerlendirildi.
Diffuse idiopathic necrobiosis lipoidica: case report
Necrobiosis lipoidica is a granulomatous skin disease whose etiology and pathogenesis are not fully explained. The association of necrobiosis lipoidica with diabetes mellitus is frequently discussed and it is thought that microangiopathy plays an important role. Although there are many treatment options, there is no standard treatment model. In this study; a 43-year-old female patient with common skin lesions and punch biopsy and necrobiosis lipoidica diagnosis was presented. The patient was found to have concomitant diabetes mellitus with necrobiosis lipoidica. After treatment, diabetes mellitus clinic resolves but the necrobiosis lipoidica does not fully recover; Autoimmune hepatitis was detected and immunosuppressive treatment was given and the patient's treatment was provided. In this case report, etiology and treatment of necrobiosis lipoidica have been discussed based on this case..
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