İsmail HANTA, Ezgi ÖZYİLMAZ, Oya BAYDAR, Sedat KULECİ, Ali KOCABAŞ

Sarkoidozlu Hastada Gelişen Masif Pulmoner Tromboembolizm: Bir Olgu Nedeni İle

Sarkoidoz, pulmoner tromboemboli için bilinen bir risk faktörü olmamakla birlikte son yıllarda bilinen başka risk faktörü olmaksızın sarkoidozlu hastalarda pulmoner tromboemboli gelişimi ile ilgili yeni veriler bildirilmektedir. Bu sunumda, 47 yaşında sarkoidoz tanısıyla beş aydır metilprednizolon tedavisi altında takip edilmekte olan kadın hastada gelişen bir masif tromboembolizm olgusu bildirilmiştir. Bu olgu ile, sarkoidozun pulmoner tromboembolinin risk faktörlerinden biri olabileceği ve takip altındaki sarkoidozlu hastalarda klinik bozulmanın ayırıcı tanısında pulmoner tromboembolinin de akılda tutulması gerekliliği düşünülmüştür.

Anahtar Kelimeler:

Masif pulmoner tromboemboli, sarkoidoz

Massive Pulmonary Thromboembolism In A Sarcoidosis Patient: Case Report

Although sarcoidosis is not a well known risk factor of pulmonary thromboembolism, recent investigations shows increased risk of pulmonary thromboembolism in these patients with the lack of any other risk factor. In this case report, massive pulmonary embolism was presented in a forty seven years old female patient who is followed up under metilprednisolon therapy due to sarcoidosis for five months. This patient was underlined because of that sarcoidosis may be a potential risk factor of pulmonary thromboembolism and must be kept in mind at the patients with sarcoidosis and acute deletoration. Keywords:

Keywords:

Massive pulmonary embolism, sarcoidosis,

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1. Türk Toraks Derneği Pulmoner tromboembolizm tanı ve tedavi kılavuzu 2009. Sf: 7-12
2. Yung GL, Fedullo PF. Pulmonary Thromboembolic Disease. In Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI (Eds). Fishman’s Pulmonary Diseases and Disorders 2008 pp: 1423- 48
3. White RH. The epidemiology of venous tromboembolism. Circulation 2003; 107(23 Suppl 1). I4-8
4. Morgenthau AS, Iannuzzi MC. Recent advances in sarcoidosis. Chest 2011; 139: 174- 182 5. Nagai S, Handa T, Ito Y, Ohta K, Tamaya M, Izumi T. Outcome of sarcoidosis. Clin Chest Med 2008; 29: 565- 74
6. Nunes H, Freynet O, Naggara N, Soussan M, Weinman P, Diebold B, Brillet PY, Valeyre D. Cardiac sarcoidosis. Semin Respir Crit Care Med. 2010; 31: 428-41
7. Lower EE, Weiss KL. Neurosarcoidosis. Clin Chest Med 2008; 29: 475- 92
8. Vahid B, Wildemore B, Marik PE. Multiple venous thromboses in a young man with sarcoidosis: is there any relation between sarcoidosis and venous thrombosis? South Med J 2006; 99: 998- 9
9. Rebeiz TJ, Mahfouz R, Taher A, Charafeddine KH, Kanj N. Unusual presentation of a sarcoid patient: multiple arterial and venous thrombosis with chest lympadenopathy. J Thromb Thrombolysis 2009; 28: 245- 7
10. McLaughin AM, McNicholas S. Sarcoidosis presenting as upper extremity venous thrombosis. Thorax 2003; 58: 552
11. Wynne JW, Ryerson GG, Dalovisio J. Myocardial sarcoidosis complicated by mural thrombosis. Thorax. 1979; 34: 127-9
12. Tanaka T, Nakata Y, Okazaki M, Kobayashi Y, Kishi T, Ejiri T, et al. Myocardial sarcoidosis with a tumorlike left atrial thrombus. Acta Pathol Jpn. 1984; 34(5):1179-92
13. Akova YA, Kansu T, Duman S. Pseudotumor cerebri secondary to dural sinus thrombosis in neurosarcoidosis.J Clin Neuroophthalmol. 1993 Sep;13(3):188-9
14. McPherson JG 3rd, Yeoh CB. Rare manifestations of sarcoidosis. J Natl Med Assoc. 1993; 85(11): 869-72
15. [No authors listed]. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1984. Longstanding sarcoidosis with the recent onset of the superior-vena-cava syndrome. N Engl J Med. 1984; 310(11): 708-16
16. Crawshaw AP, Wotton CJ, Yeates DG, Goldacre MJ, Ho LP Evidence for association between sarcoidosis and pulmonary embolism from 35-year record linkage study. Thorax. 2011;66(5): 447-8
17. Swigris JJ, Olson AL, Huie TJ, Fernandez-Perez ER, Solomon JJ, Sprunger D, et al. Increased risk for pulmonary embolism among US decedents with sarcoidosis from 1988-2007. Chest. 2011 May 12. [Epub ahead of print]
18. Hasday JD, Bachwich PR, Lynch JP 3rd, Sitrin RG. Procoagulant and plasminogen activator activities of bronchoalveolar fluid in patients with sarcoidosis. Exp Lung Res 1988; 14: 261- 78
19. Takahashi F, Toba M, Takahashi K, Tominaga S, Sato K, Morio Y, et al. Pulmonary sarcoidosis and antiphospholipid syndrome. Respirology. 2006; 11(4): 506-8