Romatizmal hastalığı olan bireylerde COVID-19 klinik özelliklerinin ve sonuçlarının değerlendirilmesi

Amaç: Bu çalışmanın amacı romatizmal hastalığı olan bireylerde koronavirüs hastalığı 2019'un (COVID-19) klinik özelliklerini ve seyrini değerlendirmektir. Gereç ve Yöntem: Bu retrospektif çalışma, 1 Temmuz-1 Ağustos 2021 tarihleri arasında Erciyes Üniversitesi Romatoloji polikliniğinde gerçekleştirildi. Hastaların demografik ve klinik verileri ile kısa COVID-19 öyküsü ve COVID-19'un klinik seyri, yorgunluk ve ağrı düzeyleri değerlendirildi. Romatizmal hastalığı olan ve COVID-19 geçirmiş olan hastaların verileri kurumsal elektronik kayıt veri tabanımızdan ve hasta dosyalarından elde edilmiştir. Bulgular: Çalışmaya alınan katılımcılar arasında romatizmal hastalığı olan, laboratuvar testleri ile COVID-19 olduğu doğrulanan ve COVID-19 enfeksiyonundan iyileşmiş olan 106 kişi (%83 kadın, %17 erkek) yer aldı. Yaş ortalamaları 48,69±11,5 yıl ve vücut kitle indeksi (VKİ) 29,89±6,76 kg/m2 idi. Ayrıca 21'i (%19,8) hastaneye kaldırılmış ve beşi (%4,7) yoğun bakıma yatırılmıştı. En sık görülen romatizmal hastalıklar aksiyel spondiloartrit (40; %37.7) ve romatoid artrit (26 vaka; %24.5) idi. Konvansiyonel sentetik hastalık modifiye edici ilaçlar (csDMARD'lar) alan hastalar biyolojik ajan ve nonsteroidal antiinflamatuar ilaç (NSAID) gruplarına göre daha fazla ağrı, yorgunluk ve baş ağrısı yaşadıklarını bildirdi. Sonuç: Çalışma sonuçlarımız, COVID-19'dan iyileşen ve csDMARD, biyolojik ajan veya NSAID alan romatizmal hastalığı olan hastalar arasında benzer semptomlar ve hastaneye yatış oranlarını ortaya koymaktadır. Ancak csDMARD grubundaki hastalar diğer gruplara göre daha fazla ağrı, yorgunluk ve baş ağrısı bildirdiler.

Anahtar Kelimeler:

Coronavirüs, COVID-19, romatizmal hastalık, otoimmün

Evaluation of COVID-19 clinical features and outcomes in individuals with rheumatic disease

features and course of coronavirus disease 2019 (COVID-19) in individuals with rheumatic disease. Materials and Methods: This retrospective study was carried out at the Erciyes University rheumatology outpatient clinic from July 1 to August 1, 2021. The demographic and clinical data and summarized COVID-19 history, clinical course of COVID-19, fatigue, and pain levels of patients with rheumatic disease were obtained from our institutional electronic registration database and patient files. Results: Recruited participants were 106 individuals (83% female, %17 male) with rheumatic disease who had been confirmed by laboratory tests to have COVID-19 and recovered from the COVID-19 infection. Their mean age and body mass index (BMI) were 48.69±11.5 years and 29.89±6.76 kg/m2, respectively. Additionally, 21 (19.8%) had been hospitalized, and five (4.7%) had been admitted to the intensive care unit. The most common rheumatic diseases were axial spondyloarthritis (40; 37.7%) and rheumatoid arthritis (26 cases; 24.5%). Patients who received conventional synthetic disease-modifying drugs (csDMARDs) reportedly experienced more pain, fatigue, and headaches than those in the biologic agent and non-steroidal anti-inflammatory drug (NSAID) groups. Conclusion: Our study results reveal similar symptoms and hospitalization rates among patients with rheumatic disease who recovered from COVID-19 and received either csDMARDs, biologic agents, or NSAIDs. However, patients in the csDMARD group reported more pain, fatigue, and headache compared to the other groups.

Keywords:

Coronavirus, rheumatic disease, autoimmune. Coronavirüs, COVID-19, romatizmal hastalık, otoimmün,

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