Sebile KILAVUZ, Diğdem BEZEN, Necdet SÜT, Emine DİLEK, Filiz TÜTÜNCÜLER

Türkiye’nin Trakya bölgesinde erken prepubertal gelişim ile takip edilen 367 çocuğun biyokimyasal klinik ve etiyolojik özellikleri

Amaç: Menarşın dokuz yaşından önce ortaya çıkması, ikincil cinsiyet özelliklerinin kızlarda 8, erkeklerde 9 yaşından önce görülmesi Erken Puberte (EP) olarak tanımlanır. Bu çalışmanın amacı, EP'li çocukların etiyolojilerini, klinik bulgularını tanımlamak ve antropometrik özellikleri ile biyokimyasal özelliklerini karşılaştırmaktır. Yöntem: Bu tek merkezli çalışmada tıbbi kayıtları incelenen 367 hastaya erken telarş (ET), erken adrenarş (EA), gerçek erken puberte (GEP) ve Periferik Erken Puberte (PEP) tanıları kondu. Tanı klinik, laboratuvar, radyolojik incelemeler ve bunların takibine dayanıyordu. Bulgular: Altı yıl içinde 349 kız (%95,1) ve 18 erkek (%4,9) EP tanısı aldı. En sık etiyoloji sırasıyla GEP;127 (%34,6), ET;117 (%31,9), EA;112(%30,5) ve PEP 11(%3) idi. GEP grubunda boy, kilo, vücut kitle indeksi (BMI) ve obezite/fazla kilolu insidansı, östradiol (E2), bazal lüteinize edici hormon (LH), pik LH ve pik LH/FSH oranı anlamlı olarak daha yüksekti ve ET grubuna göre uterus boyutları daha yüksekken, ET grubu GEP grubuna göre anlamlı olarak daha yüksek pik FSH seviyelerine sahipti (p

Anahtar Kelimeler:

Central precocious puberty, premature thelarche, premature adrenarche, Estradiol, DHEA-S, FSH, LH.

Etiological, clinical and biochemical characteristics of 367 children with early pubertal development from the Trakya region of Turkey

Background: Appearance of menarche before nine years of age, secondary sex characteristics before 8 in girls and 9 in boys is defined as Precocious Puberty (PP). Objective: The aim of this study was to describe etiologies, clinical findings, and compare anthropometric properties and biochemical characteristics of children with PP. Methods: In this single-centre study, 367 patients of whom medical records were reviewed diagnosed as premature thelarche (PT), premature adrenarche (PA), Central PP (CPP), and peripheral PP (PPP). The diagnosis was based on clinical, laboratory, and radiologic investigations and their follow-up. Results: During six years, 349 girls (%95,1) and 18 boys (%4,9) diagnosed as PP. The most common etiologies were CPP;127 (%34,6), PT;117 (%31,9), PA;112(%30,5) and PPP 11(%3), respectively. CPP group had significantly higher levels of height, weight, body mass index (BMI) and obesity/overweight incidence, estradiol (E2), basal luteinizing hormone (LH), peak LH, and peak LH/ follicle-stimulating hormone (FSH) ratio and higher uterine dimensions compared to the PT group while the PT group had significantly higher levels of peak FSH compared to the CPP group (p

Keywords:

Central precocious puberty, premature thelarche, premature adrenarche, Estradiol, DHEA-S, FSH, LH.,

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