Mustafa Kurthan MERT, Ferda ÖZLÜ, Hacer YAPICIOĞLU YILDIZDAŞ, Mehmet SATAR

Preterm bebeklerin nozokomiyal sepsisinde pentoksifilin tedavisi

Amaç: Nozokomiyal sepsis, hastane kaynaklı kazanılmış infeksiyonlar arasında en sık olanıdır. Uygun antibiyotik tedavisine rağmen sepsisin mortalitesi ve morbiditesi hala yüksektir. Bu nedenle diğer tedavi yöntemleri hala aranmaktadır. Yenidoğan yoğun bakım ünitesinde yatan prematüre bebeklerde pentoksifilinin neonatal nozokomiyal sepsisin prognozu üzerine etkisini değerlendirmeyi amaçladık.Gereç ve Yöntem: Bu çalışmaya nozokomiyal sepsis tanısı konan 80 yenidoğan dahil edildi. Bunların 40'ı antibiyotiklere ek olarak pentoksifilin tedavisi alırken, diğer 40'ı almadı ve kontrol grubunu oluşturdu. Gebelik yaşı, doğum ağırlığı, 1. ve 5. dakikadaki Apgar skorları, doğum şekli, cinsiyeti, surfaktan tedavisi, ventilatör tedavisi ve erken başlangıçlı sepsis varlığı vaka grubuyla kontrol arasında karşılaştırıldı.Bulgular: Gruplar arasında tanı anında gebelik haftası, cinsiyet, doğum ağırlığı, mortalite, nötrofil sayısı veya prokalsitonin düzeylerine göre istatistiksel bir fark yoktu. Ayrıca, hastanede kalış süresi, bronkopulmonerdisplazi veya nekrotizan enterokolit gelişmesine göre de gruplar arasında istatistiksel bir fark yoktu.Sonuç: Pentoksifilin, preterm nozokomiyal sepsisin mortalitesi ve morbiditesi üzerinde önemli bir etkiye sahip değildir.

Anahtar Kelimeler:

Pentosifilin, premature, sepsis

Pentoxyfilline treatment in nosocomial sepsis of preterm infants

Purpose: Nosocomial sepsis is the most common acquired infection. Despite appropriate antibiotic treatment, mortality and morbidity of sepsis are still high. We aimed to evaluate the effect of pentoxifylline on prognosis of neonatal nosocomial sepsis in premature infants hospitalized in the neonatal intensive care unit.Materials and Methods: Eighty newborns diagnosed as nosocomial sepsis were included in this study. Forty of them received pentoxifylline treatment in addition to antibiotics, while the other 40 did not receive additional treatment and formed the control group. The sex, mode of delivery, gestational age, birth weight, Apgar scores at the 1st and 5th minutes, surfactant therapy, ventilator therapy and presence of early onset sepsis were compared between the case group and the control.Results: There was no statistical difference between groups according to gestational week, gender, birth weight, mortality, neutrophil count or procalcitonin level at the time of diagnosis. Also, there was not any statistical difference according to duration of hospitalization between the bronchopulmonary dysplasia or necrotizing enterocolitis groups.Conclusion: Pentoxifylline has no significant impact on mortality and morbidity of preterm nosocomial sepsis.

Keywords:

pentoxifylline, premature, sepsis,

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