Çiğdem EL, Mehmet SATAR, Hacer Yapıcıoğlu YILDIZDAŞ, Ferda ÖZLÜ, Hüseyin Selim ASKER

Prematüre bebeklerde beslenme intoleransında Bifidobakteriyum laktis ve Hindiba inülinin beslenme intoleransı ve ağırlık artışı üzerine etkilerinin değerlendirilmesi

Amaç: Bu çalışmanın amacı prematüre bebeklerde beslenme intoleransı ve ağırlık artışı üzerine Bifidobakteryum laktis ve Hindiba inülini’nin etkisinin değerlendirilmesidir. Gereç ve Yöntem: Beslenme intoleransı tanısıyla izlenmekte olan 89 prematüre bebek bu çalışmaya alınmıştır. Çalışma grubundaki olgulara Bifidobakteriyum laktis (5x109 CFU) + Hindiba inülini (900 mg) (Maflor şase) oral yolla verilirken, kontrol grubundaki olgulara beslenme intolransı için herhangi bir tedavi verilmedi.Bulgular: Çalışma grubundaki olgulara B. Laktis ve Hindiba inülinine ortalama 10 gün devam edilmişti. Oral beslemeye başlama ve tam enteral beslenmeye geçiş zamanları çalışma grubunda daha uzundu ve istatistiksel açıdan anlamlı idi. Çalışma grubundaki olgularda daha düşük doğum tartısı, daha fazla sayıda yaşa göre düşük ağırlıklı olgu sayısı, daha uzun süre total parental nutrisyon almaları, oral beslenmeye daha geç başlama ve tam enteral beslenme geçiş zamanının daha uzun olmasına rağmen taburculuktaki kiloları karşılaştırıldığında kontrol grubu ile aralarında istatistiksel açıdan anlamlı fark yoktu. Gruplar kilo artışı yönünden karşılaştırıldığında çalışma grubundaki bebeklerin daha fazla kilo aldığı gözlendi ve bu sonuç istatistiksel açıdan anlamlı idi. Çalışmamızda nekrotizan enterokolit açısından gruplar arasında istatistiksel açıdan anlamlı fark yoktu. Ancak çalışma grubundaki olgular evre 1’de kalırken, kontrol grubundaki olguların %33.3’nün evre 2’ ye ilerlediği gözlendi.Sonuç: Beslenme intoleransı olan prematüre bebeklerde B. laktis ve Hindiba inülini verilen grubun ağırlık artışının daha fazla oluşu ve neckrotizan enterokolitli olguların evrelerinin ilerlememesi probiyotik ve prebiyotiklerin olumlu etkileri olduğunu düşündürmektedir.

Anahtar Kelimeler:

Probiotikler, prebiotikler, beslenme intoleransı, prematüre bebekler

Evaluation of influence of Bifidobacterium lactis and Hindiba inulin on feeding intolerance and weight gain in premature babies

Purpose: The aim of this study was to evaluate the influence of Bifidobacterium lactis and Hindiba inulin on feeding intolerance and weight gain in premature babies.Material and Methods: Eighty nine premature babies with the diagnosis of feeding intolerance were enrolled in the study. Study group had Bifidobacterium lactis (5x109 CFU) + Hindiba inulin (900 mg) (Maflor) per oral, while control group did not have any medication for feeding intolerance. Results: B. lactis ve H. inulin was continued for a mean of 10 days. Time of full enteral feeding and time of starting oral feeding were longer in study group and this was statistically significant. Although lower birth weight, longer total parenteral nutrition duration, later starting of oral feeding and longer duration for start of full enteral feeding in the study group, there was no statistical difference in weights of the babies at discharge time when compared with the control group. When the groups were compared according to weight gain, study group gained more weight and it was statistically significant. Although necrotizing enterocolitis was not significantly different between groups, babies in the study group diagnosed as in Stage 1 and did not worsen. 33.3% of the babies in the control group progressed to Stage 2. Conclusion: Probiotics and prebiotics might have positive effects due to higher weight gain especially >1500 g birth weight infants and not advancing necrotizing enterocolitis in the study group having B. Lactis and H. inulin.

Keywords:

Probiotics, prebiotics, feeding intolerance, premature babies,

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