Ali ALBAY, Serhat DUYAN, Mustafa GÜNEY, Ali Korhan SIĞ, Erman ATAŞ, Abdullah KILIÇ

Mycobacterium abscessus’un neden olduğu kan dolaşımı enfeksiyonu

Mycobacterium abscessus kompleksin de dahil olduğu hızlı üreyen mikobakteriler, doğal ortamda bulunan ve özellikle bağışıklığı baskılanmış hastalarda fırsatçı patojen olabilen mikroorganizmalardır. Evre 4 nöroblastoma tanısı olan 10 yaşında bir kız hastada, M. abscessus tarafından oluşturulan kan dolaşımı enfeksiyonunu bildiriyoruz. Mikroorganizmanın kan kültürü şişesinden izole edilmesini müteakip; mikroorganizma, MALDI-TOF MS ve BD Phoenix otomatize tanımlama ve ilaç duyarlılık cihazı ile tanımlanmıştır. Hastanın mevcut antimikrobiyal tedavisine ek olarak klaritromisin eklenmiş ve hasta şifa ile taburcu edilmiştir. Tüberküloz dışı mikobakteriler ciddi fırsatçı patojenler olarak karşımıza çıkmakta ve hekimlerin özellikle bağışıklığı baskılanmış hastalarda bu mikroorganizmaları değerlendirmeye almaları gerekmektedir. Antimikrobiyal direnç profilindeki değişkenlikten dolayı, tür düzeyinde tanımlama kritik rol oynamaktadır.

Bloodstream infection caused by mycobacterium abscessus

Rapidly growing mycobacteria including M. abscessus complex are normal environmental inhabitants and may become opportunistic pathogens especially in immunosuppressed hosts. We report a bloodstream infection case caused by M. abscessus in a 10 year-old female patient with stage IV neuroblastoma diagnosis. After isolation of microorganism from blood culture bottle, the microorganism was identified by matrix assisted laser desorption ionization time-of-flight mass spectrometry and BD Phoenix automated identification and drug susceptibility device. Clarithromycin was added to her current antibiotic therapy and the patient was discharged with recovery. Non-tuberculosis mycobacteria are becoming serious opportunistic pathogens, physicians must take these microorganisms under consideration for especially immunosuppressed patients. Due to wide diversity of antimicrobial resistance patterns, species level identification is crucial.

Keywords:

Non-tuberculosis mycobacteria, rapidly-growing mycobacteria, opportunistic pathogens,

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