Çocuklarda Çeşitli Malign Hastalıklarda Serumdaki Bakır, Çinko ve Magnezyum Seviyeleri

Giriş: Bakır, çinko, magnezyum dahil olmak üzere birçok iz elementlerin küçük miktarları dahi birçok biyolojik organların temel bileşenleri olarak rol oynamaktadır. Bu elementlerin serum konsantrasyonları bazı malign durumlarda değişiklik gösterirler. Bu çalışmanın amacı, çeşitli malign hastalığı olan çocukların serumlarındaki bakır, çinko ve magnezyum düzeylerini araştırmaktır. Materyal ve Metot: Çeşitli malign hastalıklara sahip 82 çocuğun ve kontrol grubunu oluşturan yaş olarak denk 21 sağlıklı çocuğun bakır, çinko ve magnezyum düzeyleri atomik absorpsiyon spektrofotometre kullanılarak ölçüldü. Bulgular: Akut lenfoblastik lösemili hastalarda ki (ALL) serum Cu, Zn ve Mg konsantrasyonları (p

Anahtar Kelimeler:

Bakır, Çinko, Magnezyum, Lösemi, Solid tümör, Bakır/Çinko oranı

Serum Copper, Zinc And Magnesium Levels in Children with Various Malignant Disorders

Introduction: The minute amounts of several trace elements including copper, zinc and magnesium play some roles as essential constituents of various biological organs. The serum concentrations these elements are modified in some malignancies. The aim of this study is to investigate the copper, zinc and magnesium levels in the serum of children with various malignant disorders. Material and Methods: The serum levels of copper, zinc and magnesium were measured in 82 children with various malignant disorders and in 21 age-matched healty controls using an atomic absorbtion spectrophotometer. Results: The serum Cu, Zn and Mg concentrations were significantly higher than matched control values among patients with acute lymphoblastic leukemia (ALL) (p

Keywords:

Copper, Zinc, Magnesium, Leukemia, Solid tumor, Copper/Zinc ratio,

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Leichtmann GA, Sitrin MD. Update on trace elements. Compr Ther 1991;17:42-8.
Leone N, Courbon D, Ducimetiere P, Zureik M. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology. 2006;17:308-14.
Ilicin G. Serum copper and magnesium levels in leukaemia and malignant lymphoma. Lancet. 1971;6:1036-7.
Rosner F, Gorfien PC. J Lab Clin Med Erythrocyte and plasma zinc and magnesium levels in health and disease.1968;72:213-219.
Aldor Y, Walach N, Modai D, Horn Y. Zinc and copper levels in plasma, erythrocytes, and whole blood in cancer patients. Klin Wochenschr. 1982;60: 375Capel ID, Pinnock MH, Williams DC, Hanham IW. The serum levels of some trace and bulk elements in cancer patients. Oncology. 1982;39:38-41.
Zuo XL, Chen JM, Zhou X, Li XZ, Mei GY. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biol Trace Elem Res. 2006; 114:41-53. BalcarBoroń A, Czerwionka-Szaflarska M, Słowik J et al. Serum iron and copper concentration in children with acute leukemia. Pol Tyg Lek. 1983;38:5-8.
Rosas R, Poo JL, Montemayor A, Isoard F et al. Utility of the copper/zinc ratio in patients with lymphoma or acute or chronic leukemias. Rev Invest Clin. 1995;47:447-52.
Gözdaşoğlu S, Cavdar AO, Arcasoy A, Akar N. Serum copper and zinc levels and copper/zinc ratio in pediatric non-Hodgkin's lymphoma. Acta Haematol.1982; 67:67-70.
Kanter RJ, Rai KR, Muniz F et al. Intracellular zinc in chronic lymphocytic leukemia. Clin Immunol Immunopathol. 1982; 24:26-32.
Sky-Peck HH. Trace metals and neoplasia. Clin Physiol Biochem. 1986;4:99-111.
Yazışma Adresi / Address for Correspondence: Dr. Serhan Küpeli Çukurova University, Faculty of Medicine Department of Pediatric Hematology and Oncology Balcalı 01330 , Adana /TURKEY e-mail: serkupeli@yahoo.com Tel: 90 535 7634549 Fax: 90 322 3387444 geliş tarihi/received :28.02.2013 kabul tarihi/accepted:01.04.2013