Çocukluk Çağı Akut Lenfoblastik Lösemisi

Birçok gelişmiş ülkede çocuklarda en yaygın ikinci ölüm nedeni olan kanser, ülkemizde ilk dört sıra içinde yer almaktadır. İmmatür lenfohematopoetik hücrelerin malign proliferasyonu ve birikimi olan lösemi, en sık görülen çocukluk çağı kanseridir. En sık görülen alt tipi olan akut lenfoblastik lösemi, vakaların % 75-80’ini oluşturur. Ülkemizde yıllık insidans hızı milyonda 34.4 olan akut len- foblastik lösemi remisyon indüksiyonu, intensifikasyon konsolidasyon ve idame fazlarından oluşan bir protokol ile tedavi edilir. Güçlendirilmiş tedaviler ile günümüzde beş yıllık olaysız sağ kalım % 80’in üzerinde bildirilmekte- dir. Akut lenfoblastik lösemi daha iyi anlaşıldıkça gelecekte sağ kalım oranları daha da artacaktır

Anahtar Kelimeler:

Akut lenfoblastik lösemi, çocuk, tedavi

Childhood Acute Lymphoblastic Leukemia

While cancer is the second most common cause of death in children in many developed countries, it ranks among the first four in Turkey. Leukemia, which is the malign prolife- ration and accumulation of lymphopoetic cells, is the most common childhood cancer. The most common subtype, ie. acute lymphoblastic leukemia constitutes 75-80 % of all childhood leukemia cases. Acute lymphoblastic leukemia with a yearly incidence of 34.4 per million in Turkey is treated with a protocol that includes induction of remission, intensification consolidation and maintenance phases. Nowadays with reinforced treatment modalities, 5-year event-free survival is reported to be over 80 %. As the understanding of acute lymphoblastic leukemia improves in the future, then survival rates will increase further

Keywords:

Acute lymphoblastic leukemia, childhood, treatment,

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