Mide karsinomu olgularında küratif rezeksiyonun erken ve geç sonuçları
Tanı ve tedavide son gelişmelere rağmen dünyada gastrik karsinoma hala malign hastalıklardan ölümlerin ana sebepleri arasında yer alır. Bu çalışmada 1989-1993 yılları arasında Cerrahpaşa Tıp Fakültesi Genel Cerrahi Anabilim Dalı'nda gastrik karsinoma nedeniyle küratif gastrektomi uygulanan hastaların sonuçları retrospektif olarak analize edilmiştir. 154 hastaya küratif rezeksiyon yapıldı. Beş yıllık ortalama sürvi %58'dir. Klinikopatolojik parametreler ile 5 yıllık sağkalım oranı arasındaki ilişki tek değişkenli ve çok değişkenli analizler ile değerlendirildi. Beş yıllık sağ kalımın logistik regresyonu çok değişkenli analizlerle yapıldığında, stage, grade, vasküler/lenfatikli/perinöral invazyon, tü¬mör invazyonu derinliği, metastatik lenf nodları seviyesi ve sayısı çalışmamızda istatistiksel olarak anlamlı bulunmuştur. Çalışmamızda sonuçlar, gastrik karsinoma-da klinisyenlere düşen en önemli görevin erken tanı koyma ve agresif cerrahi ile tedavinin yapılması gereğini göstermiştir.
Early and late results of curative resection in cases of gastric carcinoma
Background.- Despite recent advances in diagnosis and treatment, gastric carcinoma is still among the major causes of death in malignant diseases worldwide. The results of patients, whose underwent curative gastrectomy for gastric cancer at Cerrahpaşa Medical Faculty Department of General Surgery from 1989 to 1993, were analyzed, retrospectively. Design.- Clinical characteristics were retrieved from the records of patients who underwent curative gastrectomy for gastric cancer. Pathologic characteristics were determined from a detailed review of all available histopathologic slides and reports. Results.- One hundred fifty-four patients underwent curative resection during the study period in Cerrahpaşa Medical Faculty Department of General Surgery. Overall 5-year survival rate was 58%. The relationship between clinicopathologic variables and 5-year survival rate was evaluated by univariate and multivariate analysis. When a multivariate analysis with logistic regression of 5-year survival was performed, stage, grade, vascular/lymphatic/perineural invasion, depth of tumor invasion, levels of metastatic nodes and number of metastatic nodes emergedas the statistically significant in cases of curative resection. Conclusion.- These results suggest that the most important role for clinicians treating gastric carcinoma should be early diagnosis and aggressive surgery, followed by detaled pathologic examination.
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- ISSN: 1300-5227
- Başlangıç: 1998
- Yayıncı: -
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