Umut PAYZA, Zeynep KARAKAYA, Fatih TOPAL, Firdevs TOPAL, Pınar AKYOL

İRRİTABLE BARSAK SENDROMLU HASTALARDA QT DİSPERSİYONUNUN DEĞERLENDİRLMESİ

Amaç: Ortak embiriyolojik bağları nedeniyle irritable barsak sendromu (İBS) olan hastalarda kardiyak etkilenmeyi değerlendirmek ve QT, QTc, QTd, QTcd ile ilişkili intervalde olan değişiklikleri araştırmak.Metod: Çalışma prospektif olarak çalışıldı. Çalışmaya 01.01.2016-31.12.2018 yılları arasında irritable barsak sendrom tanısı almış 96 hasta dahil edildi. Ayrıca 100 sağlıklı gönüllü ile bir kontrol grubu oluşturuldu. Acil servisimize bu hastalar davet edilerek elektrokardiyogramları çekildi. Hastalarda ve gönüllülerde düzeltilmiş QT süreleri ve QT dispersiyonları Bazzet formülü kullanılarak hesaplandı. Bulgular: Çalışmaya katılan irritable barsak sendromu tanısı olan gönüllü erkeklerin yaş ortalaması 47,9 ve kadınların ise 40,2 idi. Sağlıklı gönüllülerde kadınların yaş ortalaması 40.7, erkeklerin ise 43.6 idi. Hastaların yaş ortalaması da QT ve QTc’de her hangi bir uzama görülmezken, QTd ve QTcd değerlerinde sağlıklı gönüllülere kıyasla uzama olduğu görüldü. Sonuç: Sağlıklı gönüllüler ile irritable barsak sendromu tanısı olan hastalar arasında QT ve QTC intervalinde uzama anlamlı olmamasına rağmen QTd ve QTcd anlamlı derecede uzama olduğu görüldü. Tartışma: Bizim çalışmamız bu hastaların düzeltilmiş QTd ve QTcd dispersiyonları olduğunu gösterdi. Bu sebeple irritable barsak sendromu olan hastalar için acil servislerde kullanılacak veya reçete edilecek ilaçların dikkatli seçilmesi gerekliliğini ortaya koyduk.

Anahtar Kelimeler:

İrritable barsak sendromu, QT dispersiyonu, acil servis, akılcı ilaç kullanımı

EVALUATION OF QT DISPERSION WITH IRRITABLE BOWEL SYNDROME PATIENTS;

ABSTRACT;Objectives; Because of common origin in the embryonic development in patients with Irrıtable bowel syndrome(IBS), evaluation of cardiac affects and changes of associated with QT,QTc,QTd and QTcd intervals.Materials and methods: This study worked as prospectively. 100 patients included to this study who had diagnosed IBS in 2016-2018. Also control group has formed with 100 healty volunteer. These patients was invited to our emergency room for taking their electrocardiograms.Corrected QT intervals and QT dispersion calculated with Bazzet Formula in both IBS patients and volunteers.Results: 86 IBS patients and 92 healty volunteers included in our study.Average age was 47.9 in men and 40.2 in women.Average age in healty volunteers 40.7,43.6 was in men.Theres no extension in QT and QTc intervals in average age in patients;but there is more extension in QTd and QTcd intervals with IBS patients than healty volunteers.Conclusion: Although the extension in the QT and QTc intervals between healty volunteers and patients with IBS patients is not significant ; QTd anf QTcd were significantly prolonged.Dicussıon: Our study showed that these patients had corrected QTd and QTcd dispersions.Just because of this choosing right medical drugs was important for IBS patients.

Keywords:

irritable bowel syndrome, QT dispersions, emergency room, rational drug choice,

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