UMUT PAYZA, Zeynep KARAKAYA, FATİH ESAD TOPAL, Firdevs TOPAL, Pınar Yeşim AKYOL

İrritable Barsak Sendromlu Hastalarda Qt Dispersiyonun Değerlendirilmesi

Amaç: Ortak embiriyolojik bağları nedeniyle irritable barsak sendromu (İBS) olan hastalarda kardiyak etkilenmeyi değerlendirmek ve QT, QTc, QTd, QTcd ile ilişkili intervalde olan değişiklikleri araştırmak. Metod: Çalışma prospektif olarak çalışıldı. Çalışmaya 2016-2018 yılları arasında irritable barsak sendrom tanısı almış 100 hasta dahil edildi. Ayrıca 100 sağlıklı gönüllü ile bir kontrol grubu oluşturuldu. Acil servisimize bu hastalar davet edilerek elektrokardiyogramları çekildi. Hastalarda ve gönüllülerde düzeltilmiş QT süreleri ve QT dispersiyonları Bazzet formülü kullanılarak hesaplandı. Bulgular: Çalışmaya 86 İrritable barsak Sendromu (İBS) olan hasta ve 92 sağlıklı gönüllü dahil edildi. Erkeklerin yaş ortalaması 47,9 ve kadınların ise 40,2 idi. Sağlıklı gönüllülerin ise kadınların yaş ortalaması 40,7, erkeklerin ise 43.6 idi. Hastaların yaş ortalaması da QT ve QTc’de her hangi bir uzama görülmezken, QTd ve QTcd değerlerinde sağlıklı gönüllülere kıyasla uzama olduğu görüldü. Sonuç: Sağlıklı gönüllüler ile irritable barsak sendromu tanısı olan hastalar arasında QT ve QTC intervalinde uzama anlamlı olmamasına rağmen QTd ve QTcd anlamlı derecede uzama olduğu görüldü. Tartışma: Bizim çalışmamız bu hastaların düzeltilmiş QTd ve QTcd dispersiyonları olduğunu gösterdi. Bu sebeple irritable barsak sendromu olan hastalar için acil servislerde kullanılacak veya reçete edilecek ilaçların dikkatli seçilmesi gerekliliğini ortaya koyduk.

Objectives;Because of common origin in the embryonic development in patients with Irrıtable bowel syndrome(IBS), evaluation of cardiacaffectsandchanges of associatedwithQT,QTc,QTdandQTcdintervals. Materialsandmethods: Thisstudyworked as prospectively. 100 patientsincludedtothisstudywho had diagnosed IBS in 2016-2018. Alsocontrolgroup has formedwith 100 healtyvolunteer. Thesepatientswasinvitedtoouremergencyroomfortakingtheirelectrocardiograms.Corrected QT intervalsand QT dispersioncalculatedwithBazzet Formula in both IBS patientsandvolunteers. Results: 86 IBS patientsand 92 healtyvolunteersincluded in ourstudy.Averageagewas 47.9 in men and 40.2 in women.Averageage in healtyvolunteers 40.7,43.6 was in men.Theresnoextension in QT andQTcintervals in averageage in patients;butthere is moreextension in QTdandQTcdintervalswith IBS patientsthanhealtyvolunteers. Conclusion:Althoughtheextension in the QT andQTcintervalsbetweenhealtyvolunteersandpatientswith IBS patients is not significant ; QTdanfQTcdweresignificantlyprolonged. Dicussıon: Ourstudyshowedthatthesepatients had correctedQTdandQTcddispersions.Justbecause of thischoosingrightmedicaldrugswasimportantfor IBS patients.

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