Şadiye GÜNPINAR, Olgu ALPERAT KILIÇ, Mehmet TOSUN, Tülin FIRAT

Antioxidant Characteristic of Pretreatment Hypericum Perforatum Oil Administration in a Rabbit Model of Palatal Mucosal Injury

Objective: This study was aimed to determine the antioxidant and soft tissue wound healing properties of pretreatment (p) of topical Hypericum perforatum (HP) oil in rabbits.Materials and Methods: Thirty-six New Zealand albino rabbits were randomly classified as p-HP oil (test, n = 18) and p-olive oil (control, n = 18) groups. Each groups of rabbits were topically pretreated with either HP or olive oil before the surgery. Gingival biopsies were excised and analyzed for re-epithelialization (RE), and granulation tissue maturation (GTM) and clinical appearance were scored for erythema, epithelial confluence and general wound appearance. Levels of VEGF and FGF-2 were assessed immunohistochemically. Tissue catalase (CAT) and malondialdehyde (MDA) levels were measured using ELISA. All analyses were performed on days 3, 7 and 14 after surgery. Results: Higher epithelial confluence (on the 7th day) and general wound appearance scores (on the 7th and 14th days) were determined in p-HP oil than that of p-olive oil group (p0.05). The number of positively stained FGF-2 cells was higher in the test group than that of the control group (p

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