Mustafa ÇELİK, Erdoğan SÖKMEN, Levent ÖZDEMİR

YENİ TANI ESANSİYEL HİPERTANSİYON HASTALARINDA PRESİSTOLİK DALGA AORTİK SERTLİK DERECESİNİ ÖNGÖRDÜREBİLMEKTE, FAKAT SİRKADİYEN KAN BASINCI PATERNİNİ ÖNGÖREMEMEKTEDİR

Arka plan ve Amaç: Hipertansiyon (HT) hastalarında non-dipping sirkadiyen patern ile artmış aortik sertlik derecesi, morbidite ve mortalite artışı ile ilişkilidir. Bu çalışmadaki amacımız sol ventrikül çıkım yolu (SVÇY) üzerinde transtorasik doppler ekokardiyografi (TTE) ile ölçümlenen presistolik dalganın (PSD), TTE ile ölçülen aortik sertlik parametreleri ile ilişkisinin olup olmadığının değerlendirilmesidir. Metot: Kardiyoloji polikliniğine başvuran ve yeni hipertansiyon teşhisi konan ardışık 140 hasta çalışmaya dahil edildi. Fizik muayene, laboratuar analizi, TTE ve ambülatuar kan basınç monitörizasyonu (AKBM) ile ilişkili veriler arşiv taraması yoluyla retrospektif olarak elde edildi. Hastalar, AKBM sonuçlarına göre dipper (75 hasta) ve non-dipper (65 hasta) şeklinde alt gruplara ayrıldı. PSD velositesi ile sirkadiyen patern ve aortik sertlik arasındaki ilişki incelendi. Bulgular: PSD tepe velositesi, dipper ve non-dipper HT hasta alt grupları arasında benzerdi. Spearman kore- lasyon analizinde PSD ile aortik sertlik indeksi (r=0.286; p=0.007), transmitral A velositesi (r=0.260; p=0.017), E/A oranı (r= -0.265; p=0.015) ve lateral E' velositesi (r= -0.279; p=0.013) arasında anlamlı korelasyon izlendi. Çok değişkenli lineer regresyon analizinde aortik sertlik indeksinin (β =0.525, p

Presystolic Wave Velocity May Predict Aortic Stiffness But Not Circadian Blood Pressure Pattern In Patients With Newly Diagnosed Essential Hypertension

Background and Aim: Non-dipping circadian pattern and increased aortic stiffness have been linked toincreased morbidity and mortality in patients with hypertension (HT). Our aim in the present study wasto assess whether presystolic wave (PSW) velocity measured by Doppler transthoracic echocardiography(TTE) on left ventricular outflow tract (LVOT) had relationship with circadian pattern and the aortic stiffnessparameters assessed by TTE.Methods: A total of 140 newly-diagnosed essential HT patients admitting to the cardiology outpatientpolyclinic were consecutively included. Data regarding physical examination, laboratory analysis, TTE,and ambulatory blood pressure monitoring (ABPM) were obtained retrospectively from medical records.Patients were divided into dipper (n=75) and non-dipper (n=65) groups on the basis of ABPM. Relationshipof PSW velocity with circadian pattern and aortic stiffness was evaluated.Results: Peak PSW velocity was similar between dipper and non-dipper HT subgroups. Spearman’scorrelation analysis showed a positive correlation of PSW velocity with aortic stiffness index (r=0.286;p=0.007), transmitral A velocity (r=0.260; p=0.017), E/A ratio (r=-0.265; p=0.015), and lateral E’ velocity(r=-0.279; p=0.013). In multivariate lineer regression model, aortic stiffness index (β=0.525, p

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