Mehmet SAM, Esra COŞKUNTUNCEL BİLGİ, Süleyman SOLAK, Emin UYSAL, Hatike BABAYİĞİT HANCER, Yahya Ayhan ACAR

HAFİF DERECELİ PANKREATİT OLGULARININ TANISINDA LİPAZ/AMİLAZ ORANI VE ORTALAMA PLATELET HACMİ NE KADAR GÜVENİLİRDİR?

Amaç: Bu çalışmanın amacı pankreatit tanısında lipaz/amilaz oranı ve ortalama platelet hacminin kullanıla- bilirliğini değerlendirmektir. Materyal ve Metot: Bu çalışma, üçüncü basamak bir sağlık kuruluşunun erişkin yoğun bakım kliniğinde 1 Ocak 2010 ile 31 Aralık 2015 tarihleri arasında yatan hastalar arasında retrospektif olarak yapılmıştır. Hasta- ların amilaz, lipaz ve ortalama platelet hacim değerleri kaydedilmiştir. Baltazar skoru 1 ila 3 arasındaki hafif dereceli pankreatit olguları pankreatit olmayanlarla karşılaştırılmıştır. Bulgular: Çalışmaya toplam 398 (267 pankreatit, 132 pankreatit olmayan kontrol) hasta dâhil edilmiştir. Ortalama yaş 58.87±18.65 iken hastaların 245 (%61.6) tanesi kadındı. Sonuçlarımıza göre, amilaz ve li- paz değerleri hem pankreatit (sırasıyla 1779,44±1214,46 ve 1932,68±1642,06) hem de kontrol (sırasıyla 1320,55±1252.24 ve 1719,81±1501,60) gruplarında yüksekti. Lipaz/amilaz oranlarında iki grup arasında an- lamlı bir fark vardı (p=0.006). Pankreatit tanısında lipaz/amilaz oranının 1’den büyük olduğu değerler için duyarlılığı %50, özgünlüğü ise %67 olarak hesaplandı. Ortalama platelet hacmi pankreatit ve kontrol grupla- rında farklılık göstermedi (p=0,101). Sonuç: Lipaz/amilaz oranı pankreatit tanısında faydalı olabilir fakat ortalama platelet hacminin bu konuda değeri sınırlıdır.

How Reliable are Lipase/Amylase Ratio and Mean Platelet Volume in the Diagnosis of Mild Pancreatitis Patients?

Aim: The aim of this study is to evaluate the utility of lipase/amylase ratio and mean platelet volume in thediagnosis of pancreatitis.Material and Method: This is a retrospective study conducted in a tertiary hospital’s adult intensive careunit between January 1st, 2010 and December 31st, 2015. Amylase, lipase and mean platelet volume resultswere recorded. Mild pancreatitis patients which have Balthazar score between 1 and 3 were compared topatients with Balthazar score of 0.Results: A total of 398 (267 pancreatitis, 132 non pancreatitis) patients were enrolled to the study. Meanage was 58.87±18.65 and 245 (61.6 %) of the subjects were female. Our results showed that meanamylase and lipase levels were high for both higher Balthazar score (1779.44±1214.46; 1932.68±1642.06,respectively) and Balthazar score of 0 (1320.55±1252.24; 1719.81±1501.60, respectively) groups. Therewas a significant difference for lipase/amylase ratio between two groups (p=0.006). The sensitivity andspecificity to predict Balthazar score in adult pancreatitis patients with lipase/amylase ratio at>1.0 were50% and 6 %, respectively. Mean platelet volume did not show any difference according to Balthazar scorelevels (p=0.101).Conclusion: Lipase/amylase ratio can be beneficial for the prediction of the severity of pancreatitis butmean platelet volume does not appear to be valuable marker in that manner.

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