DERİ KANSERİ HASTALARININ SERUM OKSİDATİF STRES PARAMETRELERİNİN DEĞERLENDİRİLMESİ Evaluation of Serum Oxidative Stress Parameters of Skin Cancer Patients

Giriş ve amaç: Deri kanserleri en sık görülen kanserlerden biridir. Bu kanserler non melanomve melanom olarak genellikle iki grup altında incelenir ve çoğu nonmelanomadır. Deri kanserlerinininsidansı ve mortalite oranları tüm dünyada giderek artmaktadır. Bu çalışmada hücre içiantioksidanlar olan superoksit dismutaz (SOD), katalaz (CAT), redükte glutatyon (GSH), glutatyonredüktaz (GR), glutatyon peroksidaz (GPx) gibi moleküller ile oksidatif stres belirteci olan malondialdehit(MDA) değerlerini deri kanseri hastalarında incelemek istedik.Materyal ve metod: Prospektif çalışma modifiye edilen Dünya Helsinki Deklarasyonu'na göreuygulandı. Bu çalışma üniversite hastanesinin dermatoloji departmanında yapıldı. Çalışmaya 30deri kanseri hastası ve 30 sağlıklı gönüllü alındı. Çalışmaya katılanların serumlarında hücre içiantioksidantlar ve malondialdehit seviyeleri değerlendirildiBulgular: Çalışma 33 erkek (%55), 27 kadın (%45) olmak üzere toplam 60 kişi ile gerçekleştirilmiştir.Çalışmaya katılan kişilerin hasta ve kontrol grubuna göre yaş ve cinsiyet değişkenlerikarşılaştırılmış aralarında anlamlı farklılık saptanmamıştır (p>0.05). GPx, GR, GSH, SOD, MDA,CAT değerlerinin, hasta ve kontrol grup ortalamaları arasındaki fark istatistik olarak önemli bulunmuştur(p<0.05).Sonuç: Bu çalışma deri kanseri hastalarında antioksidan serum düzeylerinin azaldığını ve oksidatifstres belirteci olan MDA’nın yüksek olduğunu göstermiştir.Anahtar Sözcu¨kler: Deri kanseri; Superoksit dismutaz; KatalazABSTRACTIntroduction and objectives: Skin cancers are one of the most common cancers. Thesecancers are usually examined under two groups as non-melanomas and melanomas, and mostnonmelanomas are . The incidence and mortality rates of skin cancers are increasing all over theworld. In this study, we want to investigated the intracellular antioxidants such as superoxidedismutase (SOD), catalase (CAT), reductase glutathione (GSH), glutathione reductase (GR),glutathione peroxidase (GPx) and malondialdehyde (MDA) values, which are oxidative stressmarkers, in skin cancer patientsMaterial and method: The prospective study was carried out according to the modified WorldHelsinki Declaration. This study was done in the dermatology department of the universityhospital. Thirty skin cancer patients and 30 healthy volunteers were included in the study.Intracellular antioxidants and levels of malondialdehyde were evaluated of participants in thestudyResults: The study consisted of 33 men (55%) and 27 women (45%). There was no significantdifference between the age and gender variables of the study participants according to thepatient and control group (p>0.05). The difference between GPx, GR, GSH, SOD, MDA, CATvalues, patient and control group averages were statistically significant (p<0.05).Conclusion: This study has shown that antioxidant serum levels are decreased in skin cancerpatients and MDA, an oxidative stress marker, is high.Keywords: Skin cancer; Superoxide dismutase; CatalaseBu çalışma Yüzüncüyıl Üniversitesi Bilimsel Araştırma Başkanlığı tarafından, 2015-TF-B321 numaralıproje ile desteklenmiştir.

Anahtar Kelimeler:

Deri kanseri, superoksit dismutaz, katalaz

ABSTRACT Introduction:Skin cancers are one of the most common cancers. These cancers are usually examined under two groups as non-melanomas and melanomas, and most nonmelanomas are (1). The incidence and mortality rates of skin cancers are increasing all over the world. In this study, we want to investigated the intracellular antioxidants such as superoxide dismutase (SOD), catalase (CAT), reductase glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx) and malondialdehyde (MDA) values, which are oxidative stress markers, in skin cancer patients Materials and Methods:The prospective study was carried out according to the modified world helsinki declaration. This study was done in the dermatology department of the university hospital. 30 skin cancer patients and 30 healthy volunteers were included in the study. Results: The study consisted of 33 men (55.0%) and 27 women (45.0%). There was no significant difference between the age and gender variables of the study participants according to the patient and control group (p> 0,05). The difference between GPX, GR, GSH, SOD, MDA, CAT values, patient and control group averages were statistically significant (p <0,05). Conclusion: This study has shown that antioxidant serum levels are decreased in skin cancer patients and MDA, an oxidative stress marker, is high.

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