FİBROMİYALJİ TANISINDA İNFLAMATUAR BİR BELİRTEÇ: PLATELET DAĞILIM GENİŞLİĞİ Platelet Distribution Width As A Novel Inflammatory Marker For Fibromyalgia
ÖZET
Amaç: Fibromiyalji sendromu (FMS), çoklu hassas noktalarda kronik yaygın ağrı ile karakterize, yorgunluk,
uykusuzluk, kognitif disfonksiyonlarda bozukluk vb. sistemik semptomlarla bir arada seyreden bir sendromdur.
Bu çalışmanın amacı, FMS tanılı hastalar ile kontrol grubu arasındaki platelet dağılım genişliği (PDW),
kırmızı küre dağılım genişliği (RDW), ortalama trombosit hacmi (MPV), nötrofil/lenfosit oranı (NLR), platelet/
lenfosit oranı (PLR) hematolojik parametrelerini araştırmak ve hastalık etyopatogenezine katkı sağlamaktır.
Gereç ve Yöntem: Fizik Tedavi ve Rehabilitasyon polikliniğine ayaktan başvuran ve ‘American College of
Rheumatology’ (ACR) kriterlerine göre FMS tanısı konan 200 hasta ve 65 sağlıklı birey çalışmaya dahil edildi.
Muayeneleri kapsamında ayrıntılı anamnez alımı, detaylı fizik muayene, hematolojik ve biyokimyasal parametreleri
incelendi. İstatistiksel olarak karşılaştırma ve analizleri yapıldı.
Bulgular: FMS grubunda PDW 17,1±1,9, RDW 12,5±1,4; MPV 8,3±1,2 fentolitre (fl); NLR 1,81±0,67; PLR
114,1±32,4 idi. Kontrol grubunun ise PDW değeri 17,6±2,1 (p=0,034); RDW 12,3±1,2; MPV 8,5±1,4; NLR
1,84±1,11; PLR 111,9±38,6 idi. Yapılan karşılaştırmalarda RDW, MPV, NLR, PLR de her iki grup arasında fark
saptanmazken; FMS tanılı hastalarda PDW, kontrol grubuna göre istatistiksel olarak anlamlı düzeyde düşük
saptandı (p
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