DOES CONSTIPATION HAVE AN EFFECT ON COGNITIVE FUNCTIONS? A PROSPECTIVE CLINICAL STUDY Kabızlığın Kognitif Fonksiyonlar Üzerine Etkisi Var Mı? Prospektif Klinik Bir Çalışma

ABSTRACT Objective: The aim of this study was to evaluate the effect of constipation on cognitive functions. Material and Methods: The study was designed prospectively. Patients diagnosed with constipation were included in the study group, while individuals without any complaints comprised the control group. Patients’ demographic characteristics, including age, gender, and education level, were evaluated. All participants of the study underwent Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Montreal Cognitive Assessment (MoCA) test, Digit Span Memory (DSM) test and Stroop test. Results: The patient and control groups consisted of 60 (mean age: 36.81±6.88 years) and 59 individuals (mean age: 36.1±10.2 years) respectively. There was no significant difference between the two groups in terms of demographic characteristics (p>0.05). The BAI and BDI scores were significantly higher in the patient group (ptient group (ppared to healthy controls, it is revealed that cognitive functions are also negatively affected by constipation, thus suggesting that clinical constipation should not be underestimated. Keywords: Constipation; Cognitive İmpairment; Depression; Anxiety ÖZET Amaç: Bu çalışmadaki amacımız, kabızlığın kognitif fonksiyonlar üzerine etkisinin olup olmadığını araştırmaktı. Gereç ve Yöntemler: Çalışma, prospektif olan dizayn edildi. Kabızlığı olduğu belirlenenler hasta grubu olarak, herhangi bir şikayeti olmayanlar ise kontrol grubu olarak çalışmaya dahil edildi. Her iki grubun yaş, cinsiyet ve eğitim süresini içeren demografik özellikleri değerlendirildi. Ayrıca çalışmaya dahil edilen tüm gönüllülere Beck Depresyon Envanteri, Beck Anksiyete Envanteri, Montreal Kognitif Değerlendirme Testi(MoCA), İleri ve Geri Sayı Menzili Testi ve Stroop Testi uygulandı. Bulgular: Sağlıklı kontrollere kıyasla kabızlığı olanlarda anksiyete ve depresyonun daha yüksek görülmesinin yanı sıra, kognitif fonksiyonların da kabızlıktan olumsuz etkilendiğinin belirlenmesi, klinik açıdan kabızlığın hiçte hafife alınmaması gerektiğini ortaya çıkarmaktadır. Sonuç: Hasta grubu 60 (ortalama yaş: 36.81±6.88), kontrol grubu (ortalama yaş:36.1±10.2) ise 59 gönüllüden oluşturuldu. Her iki grup arasında demografik özellikleri açısından anlamlı fark yoktu(p>0.05). Beck Anksiyete ve Beck Depresyon ölçek puanı hasta grubunda anlamlı derecede yüksek(sırasıyla p=0.037, p=0.004) bulunurken; MoCA alt bileşenlerinden yönetici işlevi, dikkat, lisan ve gecikmeli hatırlatma hasta grubunda anlamlı derecede düşük bulundu(p0.05). Anahtar Kelimeler: Kabızlık; Kognitif Bozukluk; Depresyon; Anksiyete

Anahtar Kelimeler:

DOES CONSTIPATION HAVE AN EFFECT ON COGNITIVE, FUNCTIONS? A PROSPECTIVE, CLINICAL STUDY

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