Şeref YÜKSEL, Ahmet AHSEN, Memnune Sena ULU, Akif ACA, Alper ELBİR

DİYABETİK OLMAYAN BİREYLERDE İNSÜLİN DİRENCİ MİKROALBÜMİNÜRİ İLİŞKİSİ

Amaç: İnsülin direnci ve mikroalbüminüri, tip 2 diyabetli hastalarda daha belirgin olmak üzere,kardiyovasküler hastalıklar için risk faktörüdür. Biz bu parametreleri diyabetik olmayan bireylerdearaştırmayı amaçladık. Gereç ve yöntemler: Çalışmamız hastanemiz iç hastalıkları polikliniğine başvuran 49 hastanındosya verileri incelenerek insülin direnci, mikroalbüminüri düzeyi, bel kalça oranı (BKO), bedenkitle indeksi (BKİ), yağ yüzdesi ve rutin biyokimyasal parametreleri kaydedildi. Bulgular: İnsülin direnci olan hastaların mikroalbüminüri düzeyleri, BKİ, yağ yüzdeleri ve yüksekduyarlıklı C-reaktif protein (hs-CRP) düzeyleri, insülin direnci olmayanlara göre yüksekti. BKO, açlıkkan şekeri, ve lipid değerleri açısından ise fark yoktu. Mikroalbüminüri düzeyi ile insülin direnci,BKİ ve yağ yüzdesi düzeyleri arasında pozitif korelasyon vardı.Sonuç: Diyabetik hastalarda, insülin direnci ve mikroalbüminüri varlığında kardiyovasküler riskartmıştır. Bu bulguların diyabetik olmayan hastalarda da bulunması kardiyovasküler mortalite riskini arttıracağından daha yakın takip edilmesi gerekir.

Association of Insulin Resistance with Microalbuminuria in Non-Diabetic Subjects

Objective: Insulin resistance and microalbuminuria are being more pronounced risk factors forcardiovascular diseases in patients with type 2 diabetes. We aimed to investigate the relationshipbetween these parameters in non-diabetic patients. Materials and Methods: Fourty-nine patients, who have been admitted to the hospital andexamined in terms ofinsulin resistance, microalbuminuria levels, waist-hip ratio (WHR), body massindex (BMI), fat percentage and routine biochemical parameters were recorded. Results: Microalbuminuria levels, BMI, fat percentages and hs-CRP levels of the patients withinsulin resistance were higher than those without insulin resistance.There was no difference interms of WHR, fasting blood glucose, and lipid levels. Conclusion: There is an increased cardiovascular risk in the presence of insulin resistance andmicroalbuminuria in diabetic patients. Nondiabetic subjects, with these findings, will increase therisk of cardiovascular mortality and should be followed up closely.

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