Emine ÇÖLGEÇEN, Gülhan GÜREL

BUPROPİONA BAĞLI JENERALİZE AKUT ÜRTİKER

Bupropion depresyon ve sigara bırakma tedavisinde kullanılan, norepinefrin ve dopamin geri alım inhibitörüdür. 1997 yılında ABD Gıda ve İlaç İdaresi (FDA) tarafından sigara bırakma tedavisinde onaylanmıştır. Bupropion, bu endikasyonda Zyban ticari ismiyle sürekli salınımlı bir ürün olarak formüle edilmiştir. En sık görülen yan etkiler iştahsızlık, ağız kuruluğu, uykusuzluk, baş ağrısı ve kabızlıktır. Bupropion ayrıca jeneralize akut ürtiker ve anjioödemi indükleyebilir. Bupropiyon kaynaklı ürtikere bazen anjioödem, artralji, serum benzeri reaksiyon veya anafilaksi belirtileri eşlik eder. Burada, sigara bırakmak için bupropiyon kullanımının neden olduğu bir jeneralize akut ürtiker olgusunu sunuyoruz.

Bupropion - Induced Generalized Acute Urticaria

Bupropion is a norepinephrine and dopamine reuptake inhibitor used to treat depression and for smoking cessation. It was approved by the U.S. Food and Drug Administration (FDA) for use as a smoking cessation in 1997. Bupropion was formulated for this indication as a sustainedrelease product marketed under the brand name Zyban. The most common side effects are loss of appetite, dry mouth, insomnia, headache and constipation. Bupropion may also induce generalized acute urticaria and angioedema. Bupropion-induced urticaria is sometimes accompanied by angioedema, arthralgia, serum-like reaction or symptoms of anaphylaxis. We report a case of generalized acute urticaria caused by bupropion used for smoking cessation.

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1. Hu LY, Liu CJ, Lu T, Hu TM, Tsai CF, Hu YW, et al. Delayed onset urticaria in depressive patients with bupropion prescription: a nationwide population-based study. 2013;8:e80064.
2. Crain D, Bhat A. Current treatment options in smoking cessation. Hosp Pract(1995). 2010 ;38:53-61.
3. Tackett AE, Smith KM. Bupropion-induced angioedema. Am J Health Syst Pharm. 2008;65:1627-1630.
4. Beyens MN, Guy C, Mounier G, Laporte S, Ollagnier M. Serious adverse reactions of bupropion for smoking cessation: analysis of the French Pharmacovigilance Database from 2001 to 2004. Drug Saf. 2008;31:1017-1026.
5. Cooper KD. Urticaria and angioedema: diagnosis and evaluation. J Am Acad Dermatol. 1991;25:166-174; discussion 174-176. Review.
6. Fays S, Tréchot P, Schmutz JL, Cuny JF, Truchetet F, Barbaud A. Bupropion and generalized acute urticaria: eight cases. Br J Dermatol. 2003;148:177-178.
7. Tuman TC, Tuman BA, Göksügür N, Kayka N, Yıldırım O. Urticaria and Angioedema Associated With Bupropion: Three Cases. Prim Care Companion CNS Disord. 2016;18(4).
8. Mitkov MV, Trowbridge RM, Lockshin BN, Caplan JP. Dermatologic side effects of psychotropic medications. Psychosomatics. 2014;55:1-20.