Demet YAVUZ, Düriye Sıla KARAGÖZ ÖZEN, Eşe BAŞBULUT, Melek BİLGİN, Mehmet Derya DEMİRAG

Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good

This study has investigated the vaccination rates against SARS-CoV-2 infection, antibody response to vaccine types, and factors affecting mortality in maintenance hemodialysis patients.98 of 143 patients undergoing hemodialysis in our clinic had 3 doses of BNT162b2 (Pfizer-BioNTechh) or CoronaVac (Sinovac Life Sciences) vaccine. Of these 98 patients, blood samples were obtained from 52 patients who agreed to obtain serum samples before and after vaccination. The serum samples were analyzed using the Abbott SARS-CoV-2 immunoassay designed to detect IgG antibodies against the receptor-binding domain of the S1 subunit of the spike protein of SARS-CoV-2. The rate of vaccination with at least one dose of vaccine was 85.3%, and the frequency of SARS-CoV-2 infection was 58.7%. The patients whose antibody titer was obtained after the third dose of vaccine (n=52) were divided into two groups according to the last vaccine type, as BioNTechh group of 16 patients and the Sinovac group of 36 patients. Considering all 52 patients with 3 doses of vaccine, the median antibody level was 397.3 (min-max) (4.5-40000) before the third vaccine dose, while 1325.3 (min-max) (10.5-40000) after the third vaccine dose (P<0.001). In patients with the last vaccine dose of Sinovac (n=36), the median antibody titer was 168.2 (min-max) (4.5-40000) before the third vaccine dose, while 851.7 (min-max) (55.2-40.000) after the third vaccine dose (P<0.01). In patients with the last vaccine dose of BioNTechh, the median antibody titer was 2738.6 (min-max) (9.4-37723.4) before the third vaccine dose, while 37575.8 (min-max) (10.5-40000) after the third vaccine dose (P=0.002). The frequency of SARS-CoV-2 infection (P=0.001) and SARS-CoV-2 infection-related mortality rates were significantly lower in vaccinated patients than in unvaccinated patients (P<0.001). SARS-CoV-2 vaccine doses elicited a high seropositive response in patients receiving maintenance dialysis. Those who received the last (3rd) dose of vaccine with BNT162b2 had higher antibody levels than those with CoronaVac/Sinovac. In addition, regardless of the vaccine type, being vaccinated with any of them decreased the incidence of SARS-CoV-2 infection and the mortality rate.

Anahtar Kelimeler:

COVID-19 vaccination, SARS-CoV-2, Maintenance hemodialysis, Mortality

Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good

Keywords:

COVID-19 vaccination, SARS-CoV-2, Maintenance hemodialysis, Mortality,

Tam Metin

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Bibtex	@araştırma makalesi { bshealthscience1274888, journal = {Black Sea Journal of Health Science}, eissn = {2619-9041}, address = {bsjhealthsci@blackseapublishers.com}, publisher = {Cem TIRINK}, year = {2023}, volume = {6}, number = {3}, pages = {398 - 403}, doi = {10.19127/bshealthscience.1274888}, title = {Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good}, key = {cite}, author = {Yavuz, Demet and Karagöz Özen, Düriye Sıla and Başbulut, Eşe and Bilgin, Melek and Demirag, Mehmet Derya} }
APA	Yavuz, D. , Karagöz Özen, D. S. , Başbulut, E. , Bilgin, M. & Demirag, M. D. (2023). Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good . Black Sea Journal of Health Science , 6 (3) , 398-403 . DOI: 10.19127/bshealthscience.1274888
MLA	Yavuz, D. , Karagöz Özen, D. S. , Başbulut, E. , Bilgin, M. , Demirag, M. D. "Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good" . Black Sea Journal of Health Science 6 (2023 ): 398-403 <
Chicago	Yavuz, D. , Karagöz Özen, D. S. , Başbulut, E. , Bilgin, M. , Demirag, M. D. "Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good". Black Sea Journal of Health Science 6 (2023 ): 398-403
RIS	TY - JOUR T1 - Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good AU - DemetYavuz, Düriye SılaKaragöz Özen, EşeBaşbulut, MelekBilgin, Mehmet DeryaDemirag Y1 - 2023 PY - 2023 N1 - doi: 10.19127/bshealthscience.1274888 DO - 10.19127/bshealthscience.1274888 T2 - Black Sea Journal of Health Science JF - Journal JO - JOR SP - 398 EP - 403 VL - 6 IS - 3 SN - -2619-9041 M3 - doi: 10.19127/bshealthscience.1274888 UR - Y2 - 2023 ER -
EndNote	%0 Black Sea Journal of Health Science Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good %A Demet Yavuz , Düriye Sıla Karagöz Özen , Eşe Başbulut , Melek Bilgin , Mehmet Derya Demirag %T Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good %D 2023 %J Black Sea Journal of Health Science %P -2619-9041 %V 6 %N 3 %R doi: 10.19127/bshealthscience.1274888 %U 10.19127/bshealthscience.1274888
ISNAD	Yavuz, Demet , Karagöz Özen, Düriye Sıla , Başbulut, Eşe , Bilgin, Melek , Demirag, Mehmet Derya . "Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good". Black Sea Journal of Health Science 6 / 3 (Temmuz 2023): 398-403 .
AMA	Yavuz D. , Karagöz Özen D. S. , Başbulut E. , Bilgin M. , Demirag M. D. Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good. BSJ Health Sci.. 2023; 6(3): 398-403.
Vancouver	Yavuz D. , Karagöz Özen D. S. , Başbulut E. , Bilgin M. , Demirag M. D. Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good. Black Sea Journal of Health Science. 2023; 6(3): 398-403.
IEEE	D. Yavuz , D. S. Karagöz Özen , E. Başbulut , M. Bilgin ve M. D. Demirag , "Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good", , c. 6, sayı. 3, ss. 398-403, Tem. 2023, doi:10.19127/bshealthscience.1274888