Haydar YÜKSEK, Murat BEYTUR, Onur AKYILDIRIM, Mustafa AKÇAY, Cansu BEYTUR, Evren KOÇ

Heterosiklik 4,5-dihidro-1H-1,2,4-triazol-5-on Türevinin Antioksidan Özelliğinin Erkek Ratlarda (Wistar albino) İn vivo Olarak Belirlenmesi

4,5-Dihidro-1H-1,2,4-triazol-5-on türevli heterosiklik bileşikler sanayide, tıpta, eczacılıkta ve kimyanın pek çokalanında önemli yere sahiptir. Bu bileşiklerin bazı biyolojik aktivite özellikleri in vitro olarak incelenmiş olupbazılarının yüksek aktivite gösterdikleri belirlenmiştir. Bu aktivitelerden biri de 1,2,4-triazol-5-on türevleriningöstermiş olduğu antioksidan özelliğidir. Mevcut araştırmada da, 3-metil-4-(3,4-dihidroksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on (3-MTA) bileşiğinin antioksidan özellik gösterip göstermediği ratlarda in vivoolarak spektrofotometrik yöntemle belirlenmiştir. Bu amaçla hayvanlar; kontrol grubu, dimetil sülfoksit (DMSO)grubu, 10 mg/kg ve 50 mg/kg 3-MTA bileşiği içeren gruplar olacak şekilde 4’e ayrılmıştır. Yapılanspektrofotometrik analizler neticesinde kontrol grubuna kıyasla serumda 10 ve 50 mg/kg dozunda 3-MTA bileşiğiuygulanan gruplarda (P

In vivo Determination of Antioxidant Properties of Heterocyclic 4,5- dihydro-1H-1,2,4-triazole-5-one Derivative in Male Rats (Wistar albino)

4,5-Dihydro-1H-1,2,4-triazol-5-one derived heterocyclic compounds have an important place in industry, medicine, pharmacy and many other fields of chemistry. Biological activity properties of these compounds have been examined in vitro, it was determined that some of them show high activity. One of these activities is the antioxidant property of 1,2,4-triazol-5-one derivatives. In the present study, the antioxidant properties of 3-methyl4-(3,4-dihydroxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one (3-MTA) were determined in rats by spectrophotometric method in vivo. For this purpose, animals were divided into 4 groups; control group, dimethyl sulfoxide (DMSO) group, 10 mg/kg and 50 mg/kg including MTA compound groups. As a result of the spectrophotometric analyzes, total antioxidant status (TAS) were increased in the serum treated groups of both 3- MTA compounds (P

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