Makbule Gezmen Karadağ, Büşra Başar Gökcen

Polikistik Over Sendromu, Obezite ve Melatonin: Etiyolojik Bakış Açısı

Polikistik over sendromu ile ilişkili üreme ve metabolik disfonksiyonlar net olarak bilinmesine rağmen, bu disfonksiyonların arasındaki mekanizmalar halen net değildir. Bu mekanizmalar için öne sürülen hipotezlerden biri de sirkadiyen ritim ile ilişkilidir. Bugüne kadar birçok üreme ve metabolik disfonksiyon sirkadiyen ritim bozukluğu ile ilişkilendirilmiştir. Özellikle polikistik over sendromlu kadınlarda sabahları geç saatlere kadar süren ve geceleri erken saatlerde başlayan melatonin ritmi ile metabolik disfonksiyonlar arasındaki ilişki son zamanlarda yapılan çalışmalar ile ortaya konulmuştur. Obezite ve melatonin arasındaki ilişki incelendiğinde, melatoninin etkisini enerji alımından ziyade enerji harcaması üzerinden sergilediği net olarak görülmektedir. Bu hormon adipogenezis, termogenezis, mitokondriyal fonksiyonlar ve adipositokin salınımı aracılığıyla enerji harcamasını etkilemekte ve anti-obezite aktivite göstermektedir. Bu derlemenin polikistik over sendromu ile ilişkili obezitede melatoninin terapötik kullanımına yönelik daha ileriki çalışmalara ışık tutacağı ve obezitenin önlenmesine yönelik stratejiler geliştirmede katkıda bulunacağı düşünülmektedir.

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