İnflamatuvar Barsak Hastalığı Olan Çocuklarda Malnütrisyon ve Beslenme Durumunun Değerlendirilmesi
Amaç: Bu kesitsel çalışmanın amacı inflamatuvar barsak hastalıkları (İBH) olan çocuklarda malnütrisyon ve beslenme durumunun değerlendirilmesidir. Bireyler ve Yöntem: Çalışmanın örneklemini Hacettepe Üniversitesi İhsan Doğramacı Çocuk Hastanesi Pediatrik Gastroenteroloji ve Hepatoloji Bölümü'nde izlenen 45 çocuk ve adölesan (n=18 ülseratif kolit, n=27 Crohn's hastalığı) oluşturmaktadır. Bireylerin geriye dönük 24 saatlik besin tüketim kaydı ve besin tüketim sıklığı, antropometrik ölçümleri alınmış ve hastalık aktivitesi (pediatrik Crohn's hastalığı aktivite indeksi (PCDAI) ve pediatrik ülseratif kolit aktivite indeksi (PUCAI)) uzman hekimler tarafından belirlenmiştir. Veriler, Beslenme Bilgi Sistemi 6.1 (BeBİS 6.1), WHO AnthroPlus ve SPSS 15.0 programları ile değerlendirilmiştir. Bulgular: Yaşa göre boy uzunluğu Z skorlarına göre bireylerin %11.1'i çok kısa/bodur (
An Evaluation of Malnutrition and Nutritional Status of Children with Inflammatory Bowel Disease
Aim: Aim of this cross-sectional study is to evaluate nutritional status and malnutrition of children with inflammatory bowel disease. Subjects and Methods: This study was conducted on 45 volunteer pediatric inflammatory bowel disease patients (n=18 ulcerative colitis, n=27 Crohn's disease) at Hacettepe University İhsan Doğramacı Children's Hospital, Division of Pediatric Gastroenterology, Hepatology, Nutrition. 24-hour dietary recall were determined, food frequency questionnaire were applied, anthropometric meauserements were performed. Disease severity was evaluated by specialists using PCDAI (pediatric chron's disease acyivity index)and PUCAI (pediatric ulserative colit acyivity index). Data analysis were performed using BeBİS 6.1, WHO AnthroPlus and SPSS 15.0. Results: 11.1% of patients were stunted, 28.9% were short according to height for age Z scores. 8.9% of patients were severely underweight, 8.9% of patients were underweight, 68.9% of patients were normal, 8.9% of patients were overweight, 4.4% of patients were obese. Height for age Z score were negatively correlated with cumulative corticosteroid dose (r=-0.365, p=0.022). BMI Z score were negatively correlated with age of onset (r=-0.298, p=0.047). Energy, protein (g/kg), dietary fiber, vitamins A, B1, B2, B3, B6 and folic acid, magnesium, phosphorus intake in percent of daily recommendation were significantly lower in moderate-severe patient group than both remission and mild group (p<0.05). Conclusion: Nutritional status and food intake should be monitored regularly in pediatric IBD. Individualized nutritional intervention should be performed throughout the follow-up if necessary.
___
- 1. Kliegman R, Nelson WE. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders Publishing;2007.
- 2. Mahan LK, Escott-Stump S. Krause's Food, Nutrition, & Diet Therapy. 10th ed. Philadelphia: WB Saunders Publishing; 2000.
- 3. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 2011;140(6):1785- 1794.
- 4. Logan I, Bowlus CL. The geoepidemiology of autoimmune intestinal diseases. Autoimmun Rev 2010;9 (5):A372-378.
- 5. Tozun N, Atug O, Imeryuz N, Hamzaoglu, HO, Tiftikci A, Parlak E, et al. Clinical characteristics of inflammatory bowel disease in Turkey: a multicenter epidemiologic survey. J Clin Gastroenterol 2009;43(1):51-57.
- 6. Walker WA. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management 5rd ed. Hamilton Ont; BC Decker Publishing; 2008.
- 7. Massironi S, Rossi RE, Cavalcoli FA, Della Valle S, Fraquelli M, Conte D. Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches. Clin Nutr 2013;32(6):904-910.
- 8. Hartman C, Eliakim R, Shamir R. Nutritional status and nutritional therapy in inflammatory bowel diseases. World J Gastroenterol 2009;15(21):2570-2578.
- 9. Kugathasan S, Nebel J, Skelton JA, Markowitz J, Keljo D, Rosh J, et al. Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts. J Pediatr 2007;151(5):523-527.
- 10. Griffiths AM. Growth retardation in early-onset inflammatory bowel disease: should we monitor and treat these patients differently? Dig Dis 2009;27(3):404- 411.
- 11. Heuschkel R, Salvestrini C, Beattie RM, Hildebrand H, Walters T, Griffiths A. Guidelines for the management of growth failure in childhood inflammatory bowel disease. Inflamm Bowel Dis 2008;14(6):839-849.
- 12. Conklin LS, Oliva-Hemker M. Nutritional considerations in pediatric inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2010;4(3):305-317.
- 13. Geissler C, Powers HJ, Garrow JS. Human Nutrition. 11th ed. Edinburgh, New York: Elsevier/Churchill Livingstone Publishing; 2005.
- 14. Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, Kirschner BS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991;12(4):439-447.
- 15. Turner D, Otley AR, Mack D, Hyams J, De Bruijne J, Uusoue K. et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 2007;133(2):423-432.
- 16. WHO AnthroPlus. Geneva. 2009. Available at: http:// www. who. int/growthref/ tools / en/.
- 17. Pekcan G. Beslenme Durumunun Saptanması (Eds: Baysal A, Aksoy M, Besler T, Bozkurt N, Keçecioğlu S, Kutluay Merdol T ve arkadaşları). Diyet El Kitabı. 11. Baskı. Hatiboğlu Basın ve Yayım San. Tic. Ltd. Şti, Ankara, 2011, s. 67-142.
- 18. Magkos F, Manios Y, Babaroutsi E, Sidossis LS. Development and validation of a food frequency questionnaire for assessing dietary calcium intake in the general population. Osteoporos Int 2006;17(2):304- 312.
- 19. Bebis für windows; Turkish version (BeBis 6.1). Program uses data from Bundeslebenmitte Ischlüssel (BLS) 11.3 and USDA 15. (2007). Sturttgart, Germany.
- 20. T.C. Sağlık Bakanlığı, Obezite, Diyabet ve Metabolik Hastalıklar Daire Başkanlığı, Türkiye'ye Özgü Beslenme Rehberi. Erişim:http://beslenme.gov. tr/content/files /yayinlar/kitaplar/diger_kitaplar/ beslenme_rehberi.pdf, 2004.
- 21. Alpar R. Spor, Sağlık ve Eğitim Bilimlerinden Örneklerle Uygulamalı İstatistik ve Geçerlik-Güvenirlik. 3. Baskı. Detay Yayıncılık Ankara, 2010.
- 22. Kohlstadt I. Food and Nutrients in Disease Management. 1st ed. Boca Raton; CRC Press; 2009.
- 23. Lee JJ, Escher JC, Shuman MJ, Forbes PW, Delemarre LC, Harr BW, et al. Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score. Inflamm Bowel Dis 2010;16(10):1669-1677.
- 24. Ezri J, Marques-Vidal P, Nydegger A. Impact of disease and treatments on growth and puberty of pediatric patients with inflammatory bowel disease. Digestion 2012;85(4):308-319.
- 25. Pons R, Whitten KE, Woodhead H, Leach ST, Lemberg DA, Day AS. Dietary intakes of children with Crohn's disease. Br J Nutr 2009;102(7):1052-1057.
- 26. Zopf Y, Rabe C, Kollmann S, Hahn EG, Thurauf N, Schwab D. Alterations of taste perception in Crohn's disease and their dependency on disease activity and nutritional behavior. J Clin Gastroenterol 2009;43(7):617-621.
- 27. Steinbach S, Reindl W, Dempfle A, Schuster A, Wolf P, Hundt W, et al. Smell and taste in inflammatory bowel disease. PLoS One 2013;8(9):e73454.
- 28. Geerling BJ, Badart-Smook A, Stockbrugger RW, Brummer RJ. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr 2000;54 (6): 514-521.
- 29. Lochs H, Dejong C, Hammarqvist F, Hebuterne X, Leon-Sanz M, Schutz T, et al. ESPEN Guidelines on Enteral Nutrition: Gastroenterology. Clin Nutr 2006;25(2):260-274.