Ebru KARCI, Alper Çağrı KARC, Berrin ÇETINARSLAN

Endokrinoloji Poliklinik Hastalarında Cinsiyet, Menopoz Durumu ve Glukoz Toleransının Osteokalsin Seviyeleri Üzerindeki Etkileri: Bir Vaka-Kontrol Çalışması

Amaç: Bu çalışmada, endokrinoloji poliklinik hastalarında cinsiyet, menopoz durumu ve glukoz toleransına göre total ve karboksile olmayan osteokalsin düzeylerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Oral glukoz tolerans testi (OGTT) bulguları olan toplam 178 endokrinoloji poliklinik hastası dahil edildi. Antropometri verileri [vücut kütle indeksi (VKİ), bel çevresi (cm), vücut yağ yüzdesi (BFP) ve yağ kütlesi], glisemik parametreler [açlık kan şekeri (FBG), insülin), C-peptid, HbA1c ve insülin direnç direnci (HOMA-IR)], kan lipidleri ve serum osteokalsin (OCN) seviyeleri [toplam osteokalsin (tOCN) ve karboksile olmayan osteokalsin (uOCN)] cinsiyet, menopoz durumu ve glukoz tolerans durumu ile karşılaştırıldı. Bulgular: Cinsiyet ve menopoz durumu ile ilgili olarak tOCN ve uOCN düzeylerinde anlamlı bir farklılık kaydedilmedi. Glukoz toleransı normal olan hastalarda (p

The Effects of Sex, Menopausal Status, and Glucose Tolerance on Osteocalcin Levels in Endocrinology Outpatients: A Case-Control Study

Aim: This study aimed to evaluate total and uncarboxylated osteocalcin levels concerning gender, menopausal status, and glucose tolerance in endocrinology outpatients. Material and Methods: A total of 178 endocrinology outpatients with oral glucose tolerance test (OGTT) findings were included. Data on anthropometrics [body mass index (BMI), waist circumference (cm), body fat percentage (BFP), and fat mass], glycemic parameters [fasting blood glucose (FBG), insulin), C-peptide, HbA1c, and insulin resistance (HOMA-IR)], blood lipids, and serum osteocalcin (OCN) levels [total osteocalcin (tOCN) and uncarboxylated osteocalcin (uOCN)] were compared with sex, menopausal status, and glucose tolerance status. Results: No significant difference was noted in the tOCN and uOCN levels concerning gender and menopausal status. tOCN was negatively correlated with BMI, waist circumference, BFP, and fat mass in patients with normal glucose tolerance (p

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